DPFE | CAS#945422-52-6 | glutamate receptor modulator

MedKoo Cat#: 562649 | Name: DPFE

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DPFE is a metabotropic glutamate receptor 5 positive allosteric modulator.

Chemical Structure

DPFE

CAS#945422-52-6

Theoretical Analysis

MedKoo Cat#: 562649

Name: DPFE

CAS#: 945422-52-6

Chemical Formula: C19H19F3N2O2

Exact Mass: 364.1399

Molecular Weight: 364.36

Elemental Analysis: C, 62.63; H, 5.26; F, 15.64; N, 7.69; O, 8.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DPFE;

IUPAC/Chemical Name

1-(4-(2,4-Difluorophenyl)piperazin-1-yl)-2-((4-fluorobenzyl)oxy)ethanone

InChi Key

WJPPQXQHUQEBGK-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H19F3N2O2/c20-15-3-1-14(2-4-15)12-26-13-19(25)24-9-7-23(8-10-24)18-6-5-16(21)11-17(18)22/h1-6,11H,7-10,12-13H2

SMILES Code

FC1=CC=C(C=C1)COCC(N2CCN(C3=CC=C(F)C=C3F)CC2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 364.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sengmany K, Singh J, Stewart GD, Conn PJ, Christopoulos A, Gregory KJ. Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery. Neuropharmacology. 2017 Mar 15;115:60-72. doi: 10.1016/j.neuropharm.2016.07.001. Epub 2016 Jul 5. PubMed PMID: 27392634; PubMed Central PMCID: PMC5217481. 2: Hoseinifar SH, Khalili M, Rufchaei R, Raeisi M, Attar M, Cordero H, Esteban MÁ. Effects of date palm fruit extracts on skin mucosal immunity, immune related genes expression and growth performance of common carp (Cyprinus carpio) fry. Fish Shellfish Immunol. 2015 Dec;47(2):706-11. doi: 10.1016/j.fsi.2015.09.046. Epub 2015 Oct 9. PubMed PMID: 26439417. 3: Peters J, Scofield MD, Ghee SM, Heinsbroek JA, Reichel CM. Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience. Neuropsychopharmacology. 2016 May;41(6):1477-85. doi: 10.1038/npp.2015.283. Epub 2015 Sep 14. PubMed PMID: 26365953; PubMed Central PMCID: PMC4832007. 4: Gregory KJ, Herman EJ, Ramsey AJ, Hammond AS, Byun NE, Stauffer SR, Manka JT, Jadhav S, Bridges TM, Weaver CD, Niswender CM, Steckler T, Drinkenburg WH, Ahnaou A, Lavreysen H, Macdonald GJ, Bartolomé JM, Mackie C, Hrupka BJ, Caron MG, Daigle TL, Lindsley CW, Conn PJ, Jones CK. N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement. J Pharmacol Exp Ther. 2013 Nov;347(2):438-57. doi: 10.1124/jpet.113.206623. Epub 2013 Aug 21. PubMed PMID: 23965381; PubMed Central PMCID: PMC3807069.