Synonym
KHG26693; KHG 26693; KHG-26693;
IUPAC/Chemical Name
N-(adamantan-1-yl)-4-methylthiazol-2-amine
InChi Key
JMRLYCMPIVIOSE-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H20N2S/c1-9-8-17-13(15-9)16-14-5-10-2-11(6-14)4-12(3-10)7-14/h8,10-12H,2-7H2,1H3,(H,15,16)
SMILES Code
CC1=CSC(NC23CC4CC(C3)CC(C4)C2)=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
248.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yang SJ, Kim EA, Chang MJ, Kim J, Na JM, Choi SY, Cho SW. N-Adamantyl-4-Methylthiazol-2-Amine Attenuates Glutamate-Induced Oxidative Stress and Inflammation in the Brain. Neurotox Res. 2017 Jul;32(1):107-120. doi: 10.1007/s12640-017-9717-x. Epub 2017 Mar 11. PubMed PMID: 28285348.
2: Kim J, Cho CH, Hahn HG, Choi SY, Cho SW. Neuroprotective effects of N-adamantyl-4-methylthiazol-2-amine against amyloid β-induced oxidative stress in mouse hippocampus. Brain Res Bull. 2017 Jan;128:22-28. doi: 10.1016/j.brainresbull.2016.10.010. Epub 2016 Nov 2. PubMed PMID: 27816554.
3: Cho CH, Kim EA, Kim J, Choi SY, Yang SJ, Cho SW. N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons. Free Radic Res. 2016 Jun;50(6):678-90. doi: 10.3109/10715762.2016.1167277. Epub 2016 Apr 25. PubMed PMID: 27002191.
4: Cho CH, Kim J, Ahn JY, Hahn HG, Cho SW. N-adamantyl-4-methylthiazol-2-amine suppresses lipopolysaccharide-induced brain inflammation by regulating NF-κB signaling in mice. J Neuroimmunol. 2015 Dec 15;289:98-104. doi: 10.1016/j.jneuroim.2015.10.016. Epub 2015 Oct 26. PubMed PMID: 26616878.
5: Kim EA, Han AR, Choi J, Ahn JY, Choi SY, Cho SW. Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells. Int Immunopharmacol. 2014 Sep;22(1):73-83. doi: 10.1016/j.intimp.2014.06.022. Epub 2014 Jun 25. PubMed PMID: 24975832.
6: Yang SJ, Je Lee W, Kim EA, Dal Nam K, Hahn HG, Young Choi S, Cho SW. Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2014 Aug 5;736:26-34. doi: 10.1016/j.ejphar.2014.04.031. Epub 2014 May 4. PubMed PMID: 24797782.
