RS1 | CAS#1643958-85-3 | PDK1 inhibitor

MedKoo Cat#: 562630 | Name: RS1-PDK1 inhibitor

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RS1 is a selective inhibitor of the protein kinase PDK1.

Chemical Structure

RS1-PDK1 inhibitor

CAS#1643958-85-3

Theoretical Analysis

MedKoo Cat#: 562630

Name: RS1-PDK1 inhibitor

CAS#: 1643958-85-3

Chemical Formula: C15H9ClN2O2S3

Exact Mass: 379.9515

Molecular Weight: 380.87

Elemental Analysis: C, 47.30; H, 2.38; Cl, 9.31; N, 7.36; O, 8.40; S, 25.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RS1; RS-1; RS 1; RS1-PDK1 inhibitor;

IUPAC/Chemical Name

N-(6-Chlorobenzo[d]thiazol-2-yl)benzo[b]thiophene-3-sulfonamide

InChi Key

VLGMTYRMKMVUHJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H9ClN2O2S3/c16-9-5-6-11-13(7-9)22-15(17-11)18-23(19,20)14-8-21-12-4-2-1-3-10(12)14/h1-8H,(H,17,18)

SMILES Code

O=S(C1=CSC2=CC=CC=C21)(NC3=NC4=CC=C(Cl)C=C4S3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 380.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Verma IC, Paliwal P, Singh K. Genetic Testing in Pediatric Ophthalmology. Indian J Pediatr. 2018 Mar;85(3):228-236. doi: 10.1007/s12098-017-2453-7. Epub 2017 Oct 2. Review. PubMed PMID: 28971364. 2: Koepsell H. The Na(+)-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer. Pharmacol Ther. 2017 Feb;170:148-165. doi: 10.1016/j.pharmthera.2016.10.017. Epub 2016 Oct 20. Review. PubMed PMID: 27773781. 3: Hafler BP. CLINICAL PROGRESS IN INHERITED RETINAL DEGENERATIONS: GENE THERAPY CLINICAL TRIALS AND ADVANCES IN GENETIC SEQUENCING. Retina. 2017 Mar;37(3):417-423. doi: 10.1097/IAE.0000000000001341. Review. PubMed PMID: 27753762; PubMed Central PMCID: PMC5465814. 4: Poulsen SB, Fenton RA, Rieg T. Sodium-glucose cotransport. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):463-9. doi: 10.1097/MNH.0000000000000152. Review. PubMed PMID: 26125647; PubMed Central PMCID: PMC5364028. 5: Dhital S, Warren FJ, Butterworth PJ, Ellis PR, Gidley MJ. Mechanisms of starch digestion by α-amylase-Structural basis for kinetic properties. Crit Rev Food Sci Nutr. 2017 Mar 24;57(5):875-892. doi: 10.1080/10408398.2014.922043. Review. PubMed PMID: 25751598. 6: Sieving PA, MacDonald IM, Chan S. X-Linked Juvenile Retinoschisis. 2003 Oct 24 [updated 2014 Aug 28]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from http://www.ncbi.nlm.nih.gov/books/NBK1222/ PubMed PMID: 20301401. 7: Ober MD, Freund KB, Shah M, Ahmed S, Mahmoud TH, Aaberg TM Jr, Zacks DN, Gao H, Mukkamala K, Desai U, Packo KH, Yannuzzi LA. Stellate nonhereditary idiopathic foveomacular retinoschisis. Ophthalmology. 2014 Jul;121(7):1406-13. doi: 10.1016/j.ophtha.2014.02.002. Epub 2014 Mar 22. Review. PubMed PMID: 24661864. 8: Kim DY, Mukai S. X-linked juvenile retinoschisis (XLRS): a review of genotype-phenotype relationships. Semin Ophthalmol. 2013 Sep-Nov;28(5-6):392-6. doi: 10.3109/08820538.2013.825299. Review. PubMed PMID: 24138048. 9: Liutkevičienė R, Lesauskaitė V, Ašmonienė V, Gelžinis A, Zaliūnienė D, Jašinskas V. Inherited macular dystrophies and differential diagnostics. Medicina (Kaunas). 2012;48(9):485-95. Review. PubMed PMID: 23168924. 10: Gaven F, Pellissier LP, Queffeulou E, Cochet M, Bockaert J, Dumuis A, Claeysen S. Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands. Brain Res. 2013 May 20;1511:65-72. doi: 10.1016/j.brainres.2012.11.005. Epub 2012 Nov 10. Review. PubMed PMID: 23148949. 11: Molday RS, Kellner U, Weber BH. X-linked juvenile retinoschisis: clinical diagnosis, genetic analysis, and molecular mechanisms. Prog Retin Eye Res. 2012 May;31(3):195-212. doi: 10.1016/j.preteyeres.2011.12.002. Epub 2012 Jan 3. Review. PubMed PMID: 22245536; PubMed Central PMCID: PMC3334421. 12: Vijayasarathy C, Ziccardi L, Sieving PA. Biology of retinoschisin. Adv Exp Med Biol. 2012;723:513-8. doi: 10.1007/978-1-4614-0631-0_64. Review. PubMed PMID: 22183371; PubMed Central PMCID: PMC3475158. 13: Ghosh G, Adams JA. Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J. 2011 Feb;278(4):587-97. doi: 10.1111/j.1742-4658.2010.07992.x. Epub 2011 Jan 12. Review. PubMed PMID: 21205204; PubMed Central PMCID: PMC3079193. 14: Vijayasarathy C, Takada Y, Zeng Y, Bush RA, Sieving PA. Organization and molecular interactions of retinoschisin in photoreceptors. Adv Exp Med Biol. 2008;613:291-7. doi: 10.1007/978-0-387-74904-4_34. Review. PubMed PMID: 18188957. 15: Robson AG, Michaelides M, Saihan Z, Bird AC, Webster AR, Moore AT, Fitzke FW, Holder GE. Functional characteristics of patients with retinal dystrophy that manifest abnormal parafoveal annuli of high density fundus autofluorescence; a review and update. Doc Ophthalmol. 2008 Mar;116(2):79-89. Epub 2007 Nov 6. Review. PubMed PMID: 17985165; PubMed Central PMCID: PMC2244701. 16: Kiedzierska A, Smietana K, Czepczynska H, Otlewski J. Structural similarities and functional diversity of eukaryotic discoidin-like domains. Biochim Biophys Acta. 2007 Sep;1774(9):1069-78. Epub 2007 Jul 24. Review. PubMed PMID: 17702679. 17: Sikkink SK, Biswas S, Parry NR, Stanga PE, Trump D. X-linked retinoschisis: an update. J Med Genet. 2007 Apr;44(4):225-32. Epub 2006 Dec 15. Review. PubMed PMID: 17172462; PubMed Central PMCID: PMC2598044. 18: Molday RS. Focus on molecules: retinoschisin (RS1). Exp Eye Res. 2007 Feb;84(2):227-8. Epub 2006 Apr 4. Review. PubMed PMID: 16600216. 19: Paterson DL, Bonomo RA. Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev. 2005 Oct;18(4):657-86. Review. PubMed PMID: 16223952; PubMed Central PMCID: PMC1265908. 20: Harbarth S, Samore MH. Antimicrobial resistance determinants and future control. Emerg Infect Dis. 2005 Jun;11(6):794-801. Review. PubMed PMID: 15963271; PubMed Central PMCID: PMC3367590.