MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 562617 | Name: HS-72

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HS-72 is an allosteric inhibitor selective for the inducible form of Hsp70, and discriminating Hsp70i from other Hsp70 family members including Hsc70.

Chemical Structure

HS-72
HS-72
CAS#1118861-60-1 (racemic)

Theoretical Analysis

MedKoo Cat#: 562617

Name: HS-72

CAS#: 1118861-60-1 (racemic)

Chemical Formula: C20H24N6O

Exact Mass: 364.2012

Molecular Weight: 364.45

Elemental Analysis: C, 65.91; H, 6.64; N, 23.06; O, 4.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
HS-72; HS 72; HS72;
IUPAC/Chemical Name
N-(1-Propyl-1H-benzimidazol-2-yl)-1-(2-pyrazinyl)-3(S)-piperidinecarboxamide
InChi Key
VWWVDRUMIVMLNJ-HNNXBMFYSA-N
InChi Code
InChI=1S/C20H24N6O/c1-2-11-26-17-8-4-3-7-16(17)23-20(26)24-19(27)15-6-5-12-25(14-15)18-13-21-9-10-22-18/h3-4,7-10,13,15H,2,5-6,11-12,14H2,1H3,(H,23,24,27)/t15-/m0/s1
SMILES Code
O=C([C@@H]1CN(C2=NC=CN=C2)CCC1)NC3=NC4=CC=CC=C4N3CCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 364.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hagiya K, Hayasaka K, Yamazaki T, Shirai T, Osawa T, Terawaki Y, Nagamine Y, Masuda Y, Suzuki M. Effects of heat stress on production, somatic cell score and conception rate in Holsteins. Anim Sci J. 2017 Jan;88(1):3-10. doi: 10.1111/asj.12617. Epub 2016 Apr 25. PubMed PMID: 27113198. 2: Howe MK, Speer BL, Hughes PF, Loiselle DR, Vasudevan S, Haystead TA. An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. Antiviral Res. 2016 Jun;130:81-92. doi: 10.1016/j.antiviral.2016.03.017. Epub 2016 Apr 4. PubMed PMID: 27058774; PubMed Central PMCID: PMC4955699. 3: Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA. Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. Epub 2014 Dec 11. PubMed PMID: 25500222; PubMed Central PMCID: PMC4272656. 4: Fujii S, Okinaga T, Ariyoshi W, Takahashi O, Iwanaga K, Nishino N, Tominaga K, Nishihara T. Mechanisms of G1 cell cycle arrest and apoptosis in myeloma cells induced by hybrid-compound histone deacetylase inhibitor. Biochem Biophys Res Commun. 2013 May 10;434(3):413-20. doi: 10.1016/j.bbrc.2013.03.043. Epub 2013 Mar 26. PubMed PMID: 23537658. 5: Yala SM, Fleck EM, Sciacca R, Castro D, Joseph Z, Giardina EG. Metabolic syndrome and the burden of cardiovascular disease in Caribbean Hispanic women living in northern Manhattan: a red flag for education. Metab Syndr Relat Disord. 2009 Aug;7(4):315-22. doi: 10.1089/met.2008.0071. PubMed PMID: 19558272; PubMed Central PMCID: PMC3141735. 6: Yi NJ, Suh KS, Lee HW, Shin WY, Kim J, Kim W, Kim YJ, Yoon JH, Lee HS, Lee KU. Improved outcome of adult recipients with a high model for end-stage liver disease score and a small-for-size graft. Liver Transpl. 2009 May;15(5):496-503. doi: 10.1002/lt.21606. PubMed PMID: 19399732. 7: Pojoga LH, Yao TM, Sinha S, Ross RL, Lin JC, Raffetto JD, Adler GK, Williams GH, Khalil RA. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1258-65. doi: 10.1152/ajpheart.01014.2007. Epub 2008 Jan 4. PubMed PMID: 18178722; PubMed Central PMCID: PMC2268616. 8: Inamitsu M, Itoh S, Hellman U, Ten Dijke P, Kato M. Methylation of Smad6 by protein arginine N-methyltransferase 1. FEBS Lett. 2006 Dec 11;580(28-29):6603-11. Epub 2006 Nov 14. PubMed PMID: 17118358. 9: Fukuda N, Saitoh M, Kobayashi N, Miyazono K. Execution of BMP-4-induced apoptosis by p53-dependent ER dysfunction in myeloma and B-cell hybridoma cells. Oncogene. 2006 Jun 15;25(25):3509-17. Epub 2006 Jan 30. PubMed PMID: 16449972. 10: Nakahara T, Tominaga K, Koseki T, Yamamoto M, Yamato K, Fukuda J, Nishihara T. Growth/differentiation factor-5 induces growth arrest and apoptosis in mouse B lineage cells with modulation by Smad. Cell Signal. 2003 Feb;15(2):181-7. PubMed PMID: 12464389. 11: Sato T, Koseki T, Yamato K, Saiki K, Konishi K, Yoshikawa M, Ishikawa I, Nishihara T. p53-independent expression of p21(CIP1/WAF1) in plasmacytic cells during G(2) cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Infect Immun. 2002 Feb;70(2):528-34. PubMed PMID: 11796579; PubMed Central PMCID: PMC127681. 12: Yamato K, Hashimoto S, Imamura T, Uchida H, Okahashi N, Koseki T, Ishisaki A, Kizaki M, Miyazono K, Ikeda Y, Nishihara T. Activation of the p21(CIP1/WAF1) promoter by bone morphogenetic protein-2 in mouse B lineage cells. Oncogene. 2001 Jul 19;20(32):4383-92. PubMed PMID: 11466619. 13: Hashimoto S, Ishisaki A, Yamato K, Aiko K, Amagasa T, Nishihara T. Intracellular apoptosis-inducing factor is induced by a vacuolar type H+-ATPase inhibitor in B lineage cells. J Cell Physiol. 2001 Jan;186(1):65-72. PubMed PMID: 11147815. 14: Yamato K, Hashimoto S, Okahashi N, Ishisaki A, Nonaka K, Koseki T, Kizaki M, Ikeda Y, Nishihara T. Dissociation of bone morphogenetic protein-mediated growth arrest and apoptosis of mouse B cells by HPV-16 E6/E7. Exp Cell Res. 2000 May 25;257(1):198-205. PubMed PMID: 10854068. 15: Ishisaki A, Hashimoto S, Amagasa T, Nishihara T. Caspase-3 activation during the process of apoptosis induced by a vacuolar type H(+)-ATPase inhibitor. Biol Cell. 1999 Sep;91(7):507-13. PubMed PMID: 10572626. 16: Ishisaki A, Yamato K, Hashimoto S, Nakao A, Tamaki K, Nonaka K, ten Dijke P, Sugino H, Nishihara T. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J Biol Chem. 1999 May 7;274(19):13637-42. PubMed PMID: 10224135. 17: Hashimoto O, Yamato K, Koseki T, Ohguchi M, Ishisaki A, Shoji H, Nakamura T, Hayashi Y, Sugino H, Nishihara T. The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells. Cell Signal. 1998 Nov;10(10):743-9. PubMed PMID: 9884026. 18: Ohguchi M, Ishisaki A, Okahashi N, Koide M, Koseki T, Yamato K, Noguchi T, Nishihara T. Actinobacillus actinomycetemcomitans toxin induces both cell cycle arrest in the G2/M phase and apoptosis. Infect Immun. 1998 Dec;66(12):5980-7. PubMed PMID: 9826381; PubMed Central PMCID: PMC108757. 19: Koseki T, Yamato K, Ishisaki A, Hashimoto O, Sugino H, Nishihara T. Correlation between Bcl-X expression and B-cell hybridoma apoptosis induced by activin A. Cell Signal. 1998 Jul;10(7):517-21. PubMed PMID: 9754721. 20: Ishisaki A, Yamato K, Nakao A, Nonaka K, Ohguchi M, ten Dijke P, Nishihara T. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells. J Biol Chem. 1998 Sep 18;273(38):24293-6. PubMed PMID: 9733712.

View History

Omocianine

Omocianine