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MedKoo Cat#: 562615 | Name: TTNPB
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TTNPB is a selective and highly potent agonist of retinoic acid receptors (RAR) α, β, and γ.

Chemical Structure

TTNPB
TTNPB
CAS#71441-28-6

Theoretical Analysis

MedKoo Cat#: 562615

Name: TTNPB

CAS#: 71441-28-6

Chemical Formula: C24H28O2

Exact Mass: 348.2000

Molecular Weight: 348.48

Elemental Analysis: C, 82.72; H, 8.10; O, 9.18

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
50mg USD 900.00 2 Weeks
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Related CAS #
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Synonym
TTNPB; Ro 13-7410; Ro 13 7410; Ro 137410; Ro-13-7410; Arotinoid acid;
IUPAC/Chemical Name
4-[(E)-2-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid
InChi Key
FOIVPCKZDPCJJY-JQIJEIRASA-N
InChi Code
InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
SMILES Code
O=C(O)C1=CC=C(/C=C(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)\C)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 348.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 38365890; PMCID: PMC10873380. 4: Mancini FE, Humphreys PEA, Woods S, Bates N, Cuvertino S, O'Flaherty J, Biant L, Domingos MAN, Kimber SJ. Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis. Sci Rep. 2024 Feb 1;14(1):2696. doi: 10.1038/s41598-024-52362-3. PMID: 38302538; PMCID: PMC10834951. 5: Steingruber L, Krabichler F, Franzmeier S, Wu W, Schlegel J, Koch M. ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms. Cell Tissue Res. 2023 Dec;394(3):515-528. doi: 10.1007/s00441-023-03838-7. Epub 2023 Oct 31. PMID: 37904003. 6: Ewendt F, Lehmann A, Wodak MF, Stangl GI. All-trans Retinoic Acid and Beta-Carotene Increase Sclerostin Production in C2C12 Myotubes. Biomedicines. 2023 May 12;11(5):1432. doi: 10.3390/biomedicines11051432. PMID: 37239103; PMCID: PMC10216713. 7: Lai Y, Lin H, Chen M, Lin X, Wu L, Zhao Y, Lin F, Lin C. Integration of bulk RNA sequencing and single-cell analysis reveals a global landscape of DNA damage response in the immune environment of Alzheimer's disease. Front Immunol. 2023 Feb 21;14:1115202. doi: 10.3389/fimmu.2023.1115202. PMID: 36895559; PMCID: PMC9989175. 8: Sun L, Zhang D, Qin L, Liu Q, Wang G, Shi D, Huang B. Rapid direct conversion of bovine non-adipogenic fibroblasts into adipocyte-like cells by a small- molecule cocktail. Front Cell Dev Biol. 2023 Feb 2;11:1020965. doi: 10.3389/fcell.2023.1020965. PMID: 36819108; PMCID: PMC9932023. 9: Gharbia FZ, Abouhashem AS, Moqidem YA, Elbaz AA, Abdellatif A, Singh K, Sen CK, Azzazy HME. Adult skin fibroblast state change in murine wound healing. Sci Rep. 2023 Jan 17;13(1):886. doi: 10.1038/s41598-022-27152-4. PMID: 36650180; PMCID: PMC9845335. 10: Hu Y, Yang Y, Tan P, Zhang Y, Han M, Yu J, Zhang X, Jia Z, Wang D, Yao K, Pang H, Hu Z, Li Y, Ma T, Liu K, Ding S. Induction of mouse totipotent stem cells by a defined chemical cocktail. Nature. 2023 May;617(7962):792-797. doi: 10.1038/s41586-022-04967-9. Epub 2022 Jun 21. PMID: 35728625. 11: Ma Y, Lin Y, Huang W, Wang X. Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules. Int J Mol Sci. 2022 Apr 11;23(8):4213. doi: 10.3390/ijms23084213. PMID: 35457029; PMCID: PMC9030401. 12: Latta L, Knebel I, Bleil C, Stachon T, Katiyar P, Zussy C, Fries FN, Käsmann-Kellner B, Seitz B, Szentmáry N. Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells? Biomolecules. 2021 Nov 8;11(11):1651. doi: 10.3390/biom11111651. PMID: 34827649; PMCID: PMC8615883. 13: Das M, Pethe P. Differential expression of retinoic acid alpha and beta receptors in neuronal progenitors generated from human embryonic stem cells in response to TTNPB (a retinoic acid mimetic). Differentiation. 2021 Sep- Oct;121:13-24. doi: 10.1016/j.diff.2021.08.001. Epub 2021 Aug 13. PMID: 34419635. 14: Zhang D, Ren Y, Qin L, Liu Q, Wang G, Sun L, Li M, Shi D, Huang B. Transdifferentiation of goat ear fibroblasts into lactating mammary epithelial cells induced by small molecule compounds. Biochem Biophys Res Commun. 2021 Oct 8;573:55-61. doi: 10.1016/j.bbrc.2021.07.087. Epub 2021 Aug 5. PMID: 34388455. 15: Chandrasekaran V, Carta G, da Costa Pereira D, Gupta R, Murphy C, Feifel E, Kern G, Lechner J, Cavallo AL, Gupta S, Caiment F, Kleinjans JCS, Gstraunthaler G, Jennings P, Wilmes A. Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability. Sci Rep. 2021 Jun 2;11(1):11575. doi: 10.1038/s41598-021-89550-4. 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