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MedKoo Cat#: 584424 | Name: Hns 32

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hns 32 possesses antiarrhythmic properties with vasodilator action in dog and guinea pig hearts.

Chemical Structure

Hns 32
Hns 32
CAS#186086-10-2

Theoretical Analysis

MedKoo Cat#: 584424

Name: Hns 32

CAS#: 186086-10-2

Chemical Formula: C26H33N3

Exact Mass: 387.2674

Molecular Weight: 387.57

Elemental Analysis: C, 80.58; H, 8.58; N, 10.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Hns 32; Hns32; Hns-32
IUPAC/Chemical Name
Azulene-1-carboxamidine, N,N,3,8-tetramethyl-5-(1-methylethyl)-N'-(2-pyridinylmethyl)-dimethyl-
InChi Key
IOMGMLINRUTUCG-BYCLXTJYSA-N
InChi Code
InChI=1S/C26H33N3/c1-16(2)22-13-12-17(3)23-24(20(22)6)18(4)19(5)25(23)26(29(7)8)28-15-21-11-9-10-14-27-21/h9-14,16H,15H2,1-8H3/b28-26+
SMILES Code
CC(C1=CC=C(C)C2=C(/C(N(C)C)=N\CC3=NC=CC=C3)C(C)=C(C)C2=C1C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 387.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saitoh M, Sugiyama A, Nakazawa T, Hashimoto K. Cardiovascular effects of orally administered HNS-32, an originally synthesized azulene-1-carboxamidine derivative, assessed in the in vivo rat model. Jpn J Pharmacol. 2002 Jul;89(3):316-9. PubMed PMID: 12184739. 2: Tanaka Y, Shigenobu K. A review of HNS-32: a novel azulene-1-carboxamidine derivative with multiple cardiovascular protective actions. Cardiovasc Drug Rev. 2001 Winter;19(4):297-312. Review. PubMed PMID: 11830749. 3: Noguchi K, Kase J, Saitoh M, Masumiya H, Saitoh M, Nakazawa T, Tanaka Y, Tanaka H, Hashimoto K, Shigenobu K. Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium. Pharmacology. 2002 Jan;64(1):36-42. PubMed PMID: 11731720. 4: Noguchi K, Saitoh M, Nakazawa T, Tanaka H, Tanaka Y, Shigenobu K. Cerebral artery selective inhibition of protein kinase c-mediated contraction by hns-32, a novel azulene-1-carboxamidine derivative. Res Commun Mol Pathol Pharmacol. 2000;107(1-2):45-54. PubMed PMID: 11334370. 5: Tanaka Y, Mitani A, Igarashi T, Someya S, Otsuka K, Imai T, Yamaki F, Tanaka H, Saitoh M, Nakazawa T, Noguchi K, Hashimoto K, Shigenobu K. HNS-32, a novel azulene-1-carboxamidine derivative, inhibits nifedipine-sensitive and -insensitive contraction of the isolated rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):344-52. PubMed PMID: 11284450. 6: Saitoh M, Aye NN, Komori S, Nakazawa T, Hashimoto K. Effects of HNS-32, a novel antiarrhythmic drug, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats. Mol Cell Biochem. 2000 Feb;205(1-2):133-40. PubMed PMID: 10821431. 7: Saitoh M, Sugiyama A, Hagihara A, Nakazawa T, Hashimoto K. Cardiovascular and antiarrhythmic effects of the azulene-1-carboxamidine derivative N1,N1-dimethyl-N2-(2-pyridylmethyl)-5-isopropyl-3, 8-dimethylazulene-1-carboxamidine. Arzneimittelforschung. 1997 Jul;47(7):810-5. PubMed PMID: 9272236.