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MedKoo Cat#: 584423 | Name: Hinesol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hinesol is a unique sesquiterpenoid isolated from Atractylodes lancea rhizome and has been found to induce apoptosis through the JNK signaling pathway in HL-60 cells.

Chemical Structure

Hinesol
Hinesol
CAS#23811-08-7

Theoretical Analysis

MedKoo Cat#: 584423

Name: Hinesol

CAS#: 23811-08-7

Chemical Formula: C15H26O

Exact Mass: 222.1984

Molecular Weight: 222.37

Elemental Analysis: C, 81.02; H, 11.79; O, 7.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Hinesol; (-)-Hinesol
IUPAC/Chemical Name
Spiro(4.5)dec-6-ene-2-methanol, alpha,alpha,6,10-tetramethyl-, (2R-(2alpha,5alpha(S*)))-
InChi Key
ICWHTQRTTHCUHW-JYRZLJSNSA-N
InChi Code
InChI=1S/C15H26O/c1-11-6-5-7-12(2)15(11)9-8-13(10-15)14(3,4)16/h6,12-13,16H,5,7-10H2,1-4H3/t12?,13-,15-/m1/s1
SMILES Code
OC(C)(C)[C@H]1C[C@@]2(C(C)=CCCC2C)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 222.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: He JH, Niu YF, Li JX, Wang LB, Zi TP, Yu S, Tao J. [Studies on terpenoids from Zygophyllum fabago]. Zhongguo Zhong Yao Za Zhi. 2015 Dec;40(23):4634-8. Chinese. PubMed PMID: 27141675. 2: Kasaian J, Asili J, Iranshahi M. Sulphur-containing compounds in the essential oil of Ferula alliacea roots and their mass spectral fragmentation patterns. Pharm Biol. 2016 Oct;54(10):2264-8. doi: 10.3109/13880209.2016.1152279. Epub 2016 Mar 10. PubMed PMID: 26963574. 3: Zhang Y, Miki S, Chen ML, Takeda X, Zhao DY, Kang LP, Guo LP. [Effects of Lime on Seedling Growth,Yield and Volatile Constituents of Atractylodes lancea]. Zhong Yao Cai. 2015 Mar;38(3):429-32. Chinese. PubMed PMID: 26495637. 4: Masuda Y, Kadokura T, Ishii M, Takada K, Kitajima J. Hinesol, a compound isolated from the essential oils of Atractylodes lancea rhizome, inhibits cell growth and induces apoptosis in human leukemia HL-60 cells. J Nat Med. 2015 Jul;69(3):332-9. doi: 10.1007/s11418-015-0897-5. Epub 2015 Apr 2. PubMed PMID: 25833731. 5: Na-Bangchang K, Karbwang J. Traditional herbal medicine for the control of tropical diseases. Trop Med Health. 2014 Jun;42(2 Suppl):3-13. doi: 10.2149/tmh.2014-S01. PubMed PMID: 25425945; PubMed Central PMCID: PMC4204050. 6: Li XF, Bai GB, Wang RF, Yang JF, Yuan M, An YN, Wu XW. [Study on the chemical components of volatile oil from Euphorbia pekinensis radix]. Zhong Yao Cai. 2013 Feb;36(2):237-9. Chinese. PubMed PMID: 23901651. 7: Yadav DK, Mudgal V, Agrawal J, Maurya AK, Bawankule DU, Chanotiya CS, Khan F, Thul ST. Molecular docking and ADME studies of natural compounds of Agarwood oil for topical anti-inflammatory activity. Curr Comput Aided Drug Des. 2013 Sep;9(3):360-70. PubMed PMID: 23566359. 8: Formagio AS, Vieira Mdo C, Dos Santos LA, Cardoso CA, Foglio MA, de Carvalho JE, Andrade-Silva M, Kassuya CA. Composition and evaluation of the anti-inflammatory and anticancer activities of the essential oil from Annona sylvatica A. St.-Hil. J Med Food. 2013 Jan;16(1):20-5. doi: 10.1089/jmf.2011.0303. PubMed PMID: 23297712. 9: Mirjalili MH, Hadian J, Aliahmadi A, Kanani MR, Sonboli A. Chemical composition and in vitro antimicrobial activity of the essential oil of Cyclotrichium leucotrichum from Iran. Nat Prod Res. 2013;27(10):934-7. doi: 10.1080/14786419.2012.673606. Epub 2012 Mar 29. PubMed PMID: 22455838. 10: Otoguro K, Iwatsuki M, Ishiyama A, Namatame M, Nishihara-Tukashima A, Kiyohara H, Hashimoto T, Asakawa Y, Omura S, Yamada H. In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei. Phytochemistry. 2011 Nov;72(16):2024-30. doi: 10.1016/j.phytochem.2011.07.015. Epub 2011 Aug 16. PubMed PMID: 21843897. 11: Chu SS, Jiang GH, Liu ZL. Insecticidal compounds from the essential oil of Chinese medicinal herb Atractylodes chinensis. Pest Manag Sci. 2011 Oct;67(10):1253-7. doi: 10.1002/ps.2180. Epub 2011 Apr 21. PubMed PMID: 21520395. 12: Zhang L, Ouyang Z, Zhao M, Wang P, Fang J. [Simultaneous determination of atractylone, hinesol, beta-eudesmol, atrctylodin in Atractylodes lancea and hierarchical cluster analysis]. Zhongguo Zhong Yao Za Zhi. 2010 Mar;35(6):725-8. Chinese. PubMed PMID: 20545197. 13: Fu M, Zhu D, Fang J, Song H, Yang B, Xiong Y. [Advances in chemistry, molecular biology and pharmacological of Cangzhu]. Zhongguo Zhong Yao Za Zhi. 2009 Oct;34(20):2669-72. Review. Chinese. PubMed PMID: 20069912. 14: Chen Q, Li P, Yang H, Li X, Zhu J, Chen F. Identification of volatile compounds of Atractylode lancea rhizoma using supercritical fluid extraction and GC-MS. J Sep Sci. 2009 Sep;32(18):3152-6. doi: 10.1002/jssc.200900210. PubMed PMID: 19697312. 15: Ouyang Z, Yang L, Su SL, Feng X, Wang M. [Fingerprint of volatile oil of Atractylodes lancea by GC-MS]. Yao Xue Xue Bao. 2007 Sep;42(9):968-72. Chinese. PubMed PMID: 18050740. 16: Mei WL, Zeng YB, Liu J, Dai HF. [GC-MS analysis of volatile constituents from five different kinds of Chinese eaglewood]. Zhong Yao Cai. 2007 May;30(5):551-5. Chinese. PubMed PMID: 17727060. 17: Jia C, Mao D, Zhang W, Sun X. [Studies on chemical constituents in essential oil from wild Atractylodes lancea in dabie mountains]. Zhong Yao Cai. 2004 Aug;27(8):571-4. Chinese. PubMed PMID: 15658816. 18: Du Y, Lu X. A phosphine-catalyzed [3+2] cycloaddition strategy leading to the first total synthesis of (-)-hinesol. J Org Chem. 2003 Aug 8;68(16):6463-5. PubMed PMID: 12895091. 19: Guo LP, Liu JY, Ji L, Huang LQ. [The naphtha composing characteristics of geoherbs of Atractylodes lancea]. Zhongguo Zhong Yao Za Zhi. 2002 Nov;27(11):814-9. Chinese. PubMed PMID: 12776582. 20: Ji L, Ao P, Pan JG, Yang JY, Yang J, Hu SL. [GC-MS analysis of essential oils from rhizomes of Atractylodes lancea (Thunb.) DC. and A. chinensis (DC.) Koidz]. Zhongguo Zhong Yao Za Zhi. 2001 Mar;26(3):182-5. Chinese. PubMed PMID: 12525038.