MedKoo Cat#: 571611 | Name: SMPH Crosslinker
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SMPH Crosslinker, or Succinimidyl-6-[ß-maleimidopropionamido]hexanoate is a water insoluble, heterobifunctional protein crosslinker with a non-cleavable spacer arm length of 14.3 angstroms. The SMPH crosslinking reagent is useful for making antibody drug conjugates (ADCs).

Chemical Structure

SMPH Crosslinker
SMPH Crosslinker
CAS#367927-39-7

Theoretical Analysis

MedKoo Cat#: 571611

Name: SMPH Crosslinker

CAS#: 367927-39-7

Chemical Formula: C17H21N3O7

Exact Mass: 379.1380

Molecular Weight: 379.37

Elemental Analysis: C, 53.82; H, 5.58; N, 11.08; O, 29.52

Price and Availability

Size Price Availability Quantity
100mg USD 500.00 2 weeks
1g USD 2,500.00 2 weeks
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Related CAS #
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Synonym
SMPH Crosslinker
IUPAC/Chemical Name
Succinimidyl-6-(beta-maleimidopropionamido)hexanoate
InChi Key
WCMOHMXWOOBVMZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H21N3O7/c21-12(9-11-19-13(22)5-6-14(19)23)18-10-3-1-2-4-17(26)27-20-15(24)7-8-16(20)25/h5-6H,1-4,7-11H2,(H,18,21)
SMILES Code
O=C(ON1C(CCC1=O)=O)CCCCCNC(CCN2C(C=CC2=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The SMPH crosslinking reagent has maleimide groups which are reactive to thiols (sufhydryls; -SH) and its NHS ester groups react with amines at pH 6.5-7.5 and 7-9, respectively.
Product Data
Biological target:
SMPH crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
In vitro activity:
To be determined
In vivo activity:
To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 379.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
To be determined
In vitro protocol:
To be determined
In vivo protocol:
To be determined