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MedKoo Cat#: 571610 | Name: SMPB Crosslinker
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SMPB crosslinker, or N-Succinimidyl 4-[4-maleimidophenyl]butyrate, is a heterobifunctional protein crosslinking reagent that is reactive toward sulfhydryl and amino groups. SMPB crosslinker's spacer arm is non cleavable. The SMPB protein crosslinker is an extended chain length analog of MBS crosslinker.

Chemical Structure

SMPB Crosslinker
SMPB Crosslinker
CAS#79886-55-8

Theoretical Analysis

MedKoo Cat#: 571610

Name: SMPB Crosslinker

CAS#: 79886-55-8

Chemical Formula: C18H16N2O6

Exact Mass: 356.1008

Molecular Weight: 356.33

Elemental Analysis: C, 60.67; H, 4.53; N, 7.86; O, 26.94

Price and Availability

Size Price Availability Quantity
10mg USD 430.00 2 weeks
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Related CAS #
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Synonym
SMPB Crosslinker, SMPB Cross linker, SMPB Cross-linker
IUPAC/Chemical Name
N-Succinimidyl 4-[4-maleimidophenyl]butyrate
InChi Key
PMJWDPGOWBRILU-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16N2O6/c21-14-8-9-15(22)19(14)13-6-4-12(5-7-13)2-1-3-18(25)26-20-16(23)10-11-17(20)24/h4-9H,1-3,10-11H2
SMILES Code
O=C(ON1C(CCC1=O)=O)CCCC2=CC=C(N3C(C=CC3=O)=O)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SMPB crosslinker is a crosslinking reagent that is reactive toward sulfhydryl and amino groups.
In vitro activity:
To be determined
In vivo activity:
To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 356.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
To be determined
In vitro protocol:
To be determined
In vivo protocol:
To be determined
1: Takada H, Paternoga H, Fujiwara K, Nakamoto JA, Park EN, Dimitrova-Paternoga L, Beckert B, Saarma M, Tenson T, Buskirk AR, Atkinson GC, Chiba S, Wilson DN, Hauryliuk V. A role for the S4-domain containing protein YlmH in ribosome- associated quality control in Bacillus subtilis. Nucleic Acids Res. 2024 Aug 12;52(14):8483-8499. doi: 10.1093/nar/gkae399. PMID: 38811035; PMCID: PMC11317155. 2: Duong H, Minogue E, Fullbrook S, Barry T, Reddington K. A culture-independent nucleic acid diagnostics method for use in the detection and quantification of Burkholderia cepacia complex contamination in aqueous finished pharmaceutical products. PLoS One. 2024 May 16;19(5):e0303773. doi: 10.1371/journal.pone.0303773. PMID: 38753829; PMCID: PMC11098509. 3: Bell RT, Sahakyan H, Makarova KS, Wolf YI, Koonin EV. CoCoNuTs are a diverse subclass of Type IV restriction systems predicted to target RNA. Elife. 2024 May 13;13:RP94800. doi: 10.7554/eLife.94800. PMID: 38739430; PMCID: PMC11090510. 4: Teran D, Zhang Y, Korostelev AA. Endogenous trans-translation structure visualizes the decoding of the first tmRNA alanine codon. Front Microbiol. 2024 Mar 4;15:1369760. doi: 10.3389/fmicb.2024.1369760. PMID: 38500588; PMCID: PMC10944890. 5: Rocha GD, de Simoni Gouveia JJ, da Costa MM, Soares RAN, Gouveia GV. Resistance and virulence in Staphylococcus aureus by whole-genome sequencing: a comparative approach in blaZ-positive isolates. Braz J Microbiol. 2024 Mar;55(1):955-967. doi: 10.1007/s42770-023-01243-4. Epub 2024 Jan 24. PMID: 38265572; PMCID: PMC10920469. 6: Bell RT, Sahakyan H, Makarova KS, Wolf YI, Koonin EV. CoCoNuTs: A diverse subclass of Type IV restriction systems predicted to target RNA. bioRxiv [Preprint]. 2024 Feb 10:2023.07.31.551357. doi: 10.1101/2023.07.31.551357. Update in: Elife. 2024 May 13;13:RP94800. doi: 10.7554/eLife.94800. PMID: 37790407; PMCID: PMC10542128. 7: Marathe N, Nguyen HA, Alumasa JN, Kuzmishin Nagy AB, Vazquez M, Dunham CM, Keiler KC. Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA. mBio. 2023 Oct 31;14(5):e0146123. doi: 10.1128/mbio.01461-23. Epub 2023 Sep 8. PMID: 37681945; PMCID: PMC10653918. 8: Yan Y, Li Y, Li H, Ma X, Tang Y, Yi K, Lin X, Li J, Liu Z. Antimicrobial Zeolitic Imidazolate Frameworks with Dual Mechanisms of Action. ACS Infect Dis. 2023 Mar 10;9(3):507-517. doi: 10.1021/acsinfecdis.2c00496. Epub 2023 Feb 23. PMID: 36815744. 9: Lo HH, Liao CT, Li CE, Chang HC, Hsiao YM. SsrA and SmpB have multifaceted physiological roles in the black rot pathogen Xanthomonas campestris pathovar campestris. FEMS Microbiol Lett. 2023 Jan 17;370:fnad009. doi: 10.1093/femsle/fnad009. PMID: 36750175. 10: Hashemi-Arend A, Vasquez KS, Guishard D, Naji M, Ronning A, George-Alexander G, Vasquez D, Sylvester C, Pagano W, Khalida C, Coffran C, Ezeonu T, Fofana K, Bielopolski D, Vaughan R, Qureshi A, Tobin JN, Kost RG. Implementing DASH- Aligned Meals and Self-Measured Blood Pressure to Reduce Hypertension at Senior Centers: A RE-AIM Analysis. Nutrients. 2022 Nov 18;14(22):4890. doi: 10.3390/nu14224890. PMID: 36432576; PMCID: PMC9699075. 11: Moreno S, Muriel-Millán LF, Rodríguez-Martínez K, Ortíz-Vasco C, Bedoya- Pérez LP, Espín G. The ribosome rescue pathways SsrA-SmpB, ArfA, and ArfB mediate tolerance to heat and antibiotic stresses in Azotobacter vinelandii. FEMS Microbiol Lett. 2022 Nov 17;369(1):fnac104. doi: 10.1093/femsle/fnac104. PMID: 36368695. 12: Dey A, Maiti S. Determining the Stoichiometry of Amyloid Oligomers by Single-Molecule Photobleaching. Methods Mol Biol. 2022;2538:55-74. doi: 10.1007/978-1-0716-2529-3_5. PMID: 35951293. 13: Srinivas P, Keiler KC, Dunham CM. Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action. Bioessays. 2022 Aug;44(8):e2200046. doi: 10.1002/bies.202200046. Epub 2022 Jun 19. PMID: 35719031; PMCID: PMC9308750. 14: Liu P, Chang H, Xu Q, Wang D, Tang Y, Hu X, Lin M, Liu Z. Peptide Aptamer PA3 Attenuates the Viability of Aeromonas veronii by Hindering of Small Protein B-Outer Membrane Protein A Signal Pathway. Front Microbiol. 2022 May 19;13:900234. doi: 10.3389/fmicb.2022.900234. PMID: 35663889; PMCID: PMC9159911. 15: Erpf PE, Chua SMH, Phung TK, Kerr ED, Rothnagel JA, Schulz BL, Fraser JA. Identification and characterisation of sPEPs in Cryptococcus neoformans. Fungal Genet Biol. 2022 May;160:103688. doi: 10.1016/j.fgb.2022.103688. Epub 2022 Mar 23. PMID: 35339703. 16: Zübert C, Ilic AM, Duduk B, Kube M. The Genome Reduction Excludes the Ribosomal Rescue System in Acholeplasmataceae. Microb Physiol. 2022;32(1-2):45-56. doi: 10.1159/000520450. Epub 2022 Jan 31. PMID: 35100600. 17: Campos-Silva R, D'Urso G, Delalande O, Giudice E, Macedo AJ, Gillet R. Trans-Translation Is an Appealing Target for the Development of New Antimicrobial Compounds. Microorganisms. 2021 Dec 21;10(1):3. doi: 10.3390/microorganisms10010003. PMID: 35056452; PMCID: PMC8778911. 18: D'Urso G, Guyomar C, Chat S, Giudice E, Gillet R. Insights into the ribosomal trans-translation rescue system: lessons from recent structural studies. FEBS J. 2023 Mar;290(6):1461-1472. doi: 10.1111/febs.16349. Epub 2022 Jan 26. PMID: 35015931. 19: Dey A, Vishvakarma V, Das A, Kallianpur M, Dey S, Joseph R, Maiti S. Single Molecule Measurements of the Accessibility of Molecular Surfaces. Front Mol Biosci. 2021 Dec 1;8:745313. doi: 10.3389/fmolb.2021.745313. PMID: 34926574; PMCID: PMC8672140. 20: Zhang Y, Liu Z, Tang Y, Ma X, Tang H, Li H, Liu Z. Cbl upregulates cysH for hydrogen sulfide production in Aeromonas veronii. PeerJ. 2021 Sep 9;9:e12058. doi: 10.7717/peerj.12058. PMID: 34589297; PMCID: PMC8435198.