MedKoo Cat#: 571609 | Name: Sulfo-SIA Crosslinker
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfo-SIA Crosslinker, or N-Sulfosuccinimidyl iodoacetate, is a non-cleavable, heterobifunctional protein crosslinker. Sulfo-SIA is water soluble. Sulfo-SIA Crosslinking Reagent is among the shortest amine and sulfhydryl (thiol) reactive crosslinkers known with a spacer arm length of 1.5 Angstroms. Sulfo-SIA Crosslinker is useful in making antibody drug conjugates (ADCs).

Chemical Structure

Sulfo-SIA Crosslinker
Sulfo-SIA Crosslinker
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 571609

Name: Sulfo-SIA Crosslinker

CAS#: NONE

Chemical Formula: C6H7INO7S

Exact Mass: 363.8988

Molecular Weight: 364.09

Elemental Analysis: C, 19.79; H, 1.94; I, 34.86; N, 3.85; O, 30.76; S, 8.81

Price and Availability

Size Price Availability Quantity
100mg USD 425.00
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Related CAS #
No Data
Synonym
Sulfo-SIA Crosslinker, Sulfo-SIA Cross linker, Sulfo-SIA Cross-linker
IUPAC/Chemical Name
N-Sulfosuccinimidyl iodoacetate
InChi Key
LBYKLOPOXRATHZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H7INO7S/c7-3-6(11)15-8(16(12,13)14)4(9)1-2-5(8)10/h1-3H2,(H,12,13,14)
SMILES Code
O=C(O[N]1(S(=O)(O)=O)C(CCC1=O)=O)CI
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 364.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen S, Sibley CD, Latifi B, Balaratnam S, Dorn RS, Lupták A, Schneekloth JS Jr, Prescher JA. Bioorthogonal Cyclopropenones for Investigating RNA Structure. ACS Chem Biol. 2024 Dec 6. doi: 10.1021/acschembio.4c00633. Epub ahead of print. PMID: 39641920. 2: Sul JH, Shin S, Kim HK, Han J, Kim J, Son S, Lee J, Baek SH, Cho Y, Lee J, Park J, Ahn D, Park S, Palomera LF, Lim J, Kim J, Kim C, Han S, Chung KY, Lee S, Kam TI, Lee Y, Kim J, Park JH, Jo DG. Dopamine-conjugated extracellular vesicles induce autophagy in Parkinson's disease. J Extracell Vesicles. 2024 Dec;13(12):e70018. doi: 10.1002/jev2.70018. PMID: 39641313. 3: Wang J, Li L, Guo ZH, Pan C, Pu X. Multi-crosslinked strong, tough and anti- freezing organohydrogels for flexible sensors. Nanoscale. 2024 Dec 6. doi: 10.1039/d4nr03363a. Epub ahead of print. PMID: 39641140. 4: Eze FN, Bunyapongpan A, Prapunpoj P. Neuroprotective effect against amyloidogenic transthyretin aggregates - Induced cytotoxicity on human neuroblastoma cell by phenolic-rich Centella asiatica extract. Heliyon. 2024 Oct 9;10(20):e39159. doi: 10.1016/j.heliyon.2024.e39159. PMID: 39640739; PMCID: PMC11620063. 5: Zhang Y, Yang L, Zhou M, Mou Y, Wang D, Zhang P. Insights into microscopic fabrication, macroscopic forms and biomedical applications of alginate composite gel containing metal-organic frameworks. Asian J Pharm Sci. 2024 Dec;19(6):100952. doi: 10.1016/j.ajps.2024.100952. Epub 2024 Sep 1. PMID: 39640058; PMCID: PMC11617950. 6: Ren X, Tang W, Yuan Y, Chen S, Lu F, Mao J, Fan J, Wei X, Chu M, Hu B. A Body-Temperature-Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation. Adv Sci (Weinh). 2024 Dec 6:e2412361. doi: 10.1002/advs.202412361. Epub ahead of print. PMID: 39639850. 7: Huang G, Ma J, Chen J, Zhang W, Fan Q, Han B. Controllable Strategy of Metal- Organic Framework Structural Stability: Regulation of Ligand Electronegativity by Esterification. Adv Sci (Weinh). 2024 Dec 5:e2413853. doi: 10.1002/advs.202413853. Epub ahead of print. PMID: 39639733. 8: Li X, Xie Z, Qin T, Zhan C, Jin L, Huang J. The SLR1-OsMADS23-D14 module mediates the crosstalk between strigolactone and gibberellin signaling to control rice tillering. New Phytol. 2024 Dec 5. doi: 10.1111/nph.20331. Epub ahead of print. PMID: 39639554. 9: Vořechovský I. From benign to pathogenic variants and vice versa: pyrimidine transitions at position -3 of TAG and CAG 3' splice sites. J Hum Genet. 2024 Dec 5. doi: 10.1038/s10038-024-01308-8. Epub ahead of print. PMID: 39639151. 10: Jiménez-González S, Delgado-Valero B, Romero-Miranda A, Islas F, Luaces M, Ramchandani B, Cuesta-Corral M, Montoro-Garrido A, Nieto ML, Martínez-Martínez E, Cachofeiro V. The mechanisms underlying the cardiac effects of modified citrus pectin in obese rats with myocardial ischemia: Role of galectin-3. Clin Investig Arterioscler. 2024 Dec 4:S0214-9168(24)00114-1. English, Spanish. doi: 10.1016/j.arteri.2024.10.007. Epub ahead of print. PMID: 39638645. 11: Vaz MD, Machado I, Loureiro T, Campos N. Wessely-type immune ring following collagen cross-linking. BMJ Case Rep. 2024 Dec 5;17(12):e261923. doi: 10.1136/bcr-2024-261923. PMID: 39638582. 12: Wang Y, Zhang N, Zhang J, Yao R, He J, Wu F. Reinforced enzyme mineralized chitosan hydrogels with superior mechanical and osteogenic properties. Carbohydr Polym. 2025 Feb 1;349(Pt B):123032. doi: 10.1016/j.carbpol.2024.123032. Epub 2024 Nov 19. PMID: 39638528. 13: Ji C, Shi N, Li Y, Liu D, Wei Q, Ma G, Shi X, Hu Z. A processable and recyclable gelatin/carboxymethyl chitosan hydrogel electrolyte for high performance flexible zinc-ion batteries. Carbohydr Polym. 2025 Feb 1;349(Pt B):122982. doi: 10.1016/j.carbpol.2024.122982. Epub 2024 Nov 16. PMID: 39638521. 14: Zhang K, Zhu J, Sun W, Zhang Y, Li W, Wang Y, Zhou C, He Y, Qin J. Antibacterial betaine modified chitosan-based hydrogel with angiogenic property for photothermal enhanced diabetic wound repairing. Carbohydr Polym. 2025 Feb 1;349(Pt B):123033. doi: 10.1016/j.carbpol.2024.123033. Epub 2024 Nov 19. PMID: 39638511. 15: Heidari NA, Hamdami N, Siqueira G, Nyström G. Valorizing brewery industry waste in nanocellulose cryogel-PEG composites for cold chain packaging. Carbohydr Polym. 2025 Feb 1;349(Pt B):123031. doi: 10.1016/j.carbpol.2024.123031. Epub 2024 Nov 16. PMID: 39638510. 16: Cao J, Li L, Yang X. Enhanced physicochemical properties and riboflavin delivery ability of soy isolate protein/sugar beet pectin composite freeze-dried gels prepared by double crosslinking strategy. Carbohydr Polym. 2025 Feb 1;349(Pt B):122953. doi: 10.1016/j.carbpol.2024.122953. Epub 2024 Nov 8. PMID: 39638500. 17: Zhang Z, Chen L, Wang H, Tang B, Cheng Y, Zhu M, Li X, Qi X, Shao Y, Zhang X. Multi-well plate-based versatile platform for online fabricating alginate hydrogel microspheres and in-situ 3D cell culture. Anal Chim Acta. 2025 Jan 15;1334:343427. doi: 10.1016/j.aca.2024.343427. Epub 2024 Nov 14. PMID: 39638465. 18: Cooper BF, Clark R, Kudhail A, Dunn D, Tian Q, Bhabha G, Ekiert DC, Khalid S, Isom GL. Phospholipid transport across the bacterial periplasm through the envelope-spanning bridge YhdP. J Mol Biol. 2024 Dec 3:168891. doi: 10.1016/j.jmb.2024.168891. Epub ahead of print. PMID: 39638236. 19: Li J, Zeng H, Wu X, Li T, Sun Z, Zhu G, Zhang M, Chen L, Pan K, Guo X. Chitosan-based porous composites embedded with molybdenum disulfide nanosheets for removal of mercury from wastewater. Int J Biol Macromol. 2024 Dec 3:138379. doi: 10.1016/j.ijbiomac.2024.138379. Epub ahead of print. PMID: 39638194. 20: Zhou HF, Deng WY, Guo HQ, Luo WH, Han ZQ, Cheng Z, Lau WM, Xiao NY, Zhang XQ. Antibacterial activity of polyethylene film by hyperthermal hydrogen induced cross-linking with chitosan quaternary ammonium salt. Int J Biol Macromol. 2024 Dec 3:138335. doi: 10.1016/j.ijbiomac.2024.138335. Epub ahead of print. PMID: 39638192.