MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 571608 | Name: SIA Crosslinker
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIA crosslinker (N-Succinimidyl iodoacetate; NHS-Iodoacetate) is a non-cleavable, heterobifunctional protein crosslinker. The SIA crosslinker reagent is among the shortest amine and sulfhydryl (thiol) reactive protein crosslinkers known with a spacer arm length of 1.5 Angstroms. SIA crosslinker is useful in making antibody drug conjugates (ADCs).

Chemical Structure

SIA Crosslinker
SIA Crosslinker
CAS#39028-27-8

Theoretical Analysis

MedKoo Cat#: 571608

Name: SIA Crosslinker

CAS#: 39028-27-8

Chemical Formula: C6H6INO4

Exact Mass: 282.9342

Molecular Weight: 283.02

Elemental Analysis: C, 25.46; H, 2.14; I, 44.84; N, 4.95; O, 22.61

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 weeks
250mg USD 600.00 2 Weeks
1g USD 1,050.00 2 weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
SIA Crosslinker, SIA Cross linker, SIA Cross-linker; N-Succinimidyl Iodoacetate; N-Iodoacetoxysuccinimide
IUPAC/Chemical Name
Iodoacetic acid N-hydroxysuccinimide ester
InChi Key
VRDGQQTWSGDXCU-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
SMILES Code
O=C(ON1C(CCC1=O)=O)CI
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SIA crosslinker is a non-cleavable, heterobifunctional protein crosslinker.
In vitro activity:
To be determined
In vivo activity:
To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 283.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
To be determined
In vitro protocol:
To be determined
In vivo protocol:
To be determined
1: Piñero DP, Alio JL, Klonowski P, Toffaha B. Vectorial astigmatic changes after corneal collagen crosslinking in keratoconic corneas previously treated with intracorneal ring segments: a preliminary study. Eur J Ophthalmol. 2012;22 Suppl 7:S69-80. doi: 10.5301/ejo.5000063. PubMed PMID: 22020986. 2: Nyberg G, Strömberg N, Jonsson A, Karlsson KA, Normark S. Erythrocyte gangliosides act as receptors for Neisseria subflava: identification of the Sia-1 adhesin. Infect Immun. 1990 Aug;58(8):2555-63. PubMed PMID: 2370108; PubMed Central PMCID: PMC258855. 3: Zhang M, Varki A. Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis. Glycobiology. 2004 Nov;14(11):939-49. Epub 2004 Jul 7. PubMed PMID: 15240561. 4: Liu N, Liang W, Liu L, Wang Y, Mai JD, Lee GB, Li WJ. Extracellular-controlled breast cancer cell formation and growth using non-UV patterned hydrogels via optically-induced electrokinetics. Lab Chip. 2014 Apr 7;14(7):1367-76. doi: 10.1039/c3lc51247a. PubMed PMID: 24531214. 5: Asphahani F, Zheng X, Veiseh O, Thein M, Xu J, Ohuchi F, Zhang M. Effects of electrode surface modification with chlorotoxin on patterning single glioma cells. Phys Chem Chem Phys. 2011 May 21;13(19):8953-60. PubMed PMID: 21678586; PubMed Central PMCID: PMC3205118. 6: Yang W, Yu H, Li G, Wang Y, Liu L. Facile modulation of cell adhesion to a poly(ethylene glycol) diacrylate film with incorporation of polystyrene nano-spheres. Biomed Microdevices. 2016 Dec;18(6):107. PubMed PMID: 27830453. 7: Mond JJ, Seghal E, Kung J, Finkelman FD. Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin. J Immunol. 1981 Sep;127(3):881-8. PubMed PMID: 6790620. 8: Myers RA, Zafaralla GC, Gray WR, Abbott J, Cruz LJ, Olivera BM. alpha-Conotoxins, small peptide probes of nicotinic acetylcholine receptors. Biochemistry. 1991 Sep 24;30(38):9370-7. PubMed PMID: 1892838. 9: Candiani C, Franceschi A, Chignola R, Pasti M, Anselmi C, Benoni G, Tridente G, Colombatti M. Blocking effect of human serum but not of cerebrospinal fluid on ricin A chain immunotoxin potentiation by monensin or carrier protein-monensin conjugates. Cancer Res. 1992 Feb 1;52(3):623-30. PubMed PMID: 1732050. 10: Sia SK, Carr PA, Cochran AG, Malashkevich VN, Kim PS. Short constrained peptides that inhibit HIV-1 entry. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14664-9. Epub 2002 Nov 4. PubMed PMID: 12417739; PubMed Central PMCID: PMC137476. 11: Gillette BM, Jensen JA, Tang B, Yang GJ, Bazargan-Lari A, Zhong M, Sia SK. In situ collagen assembly for integrating microfabricated three-dimensional cell-seeded matrices. Nat Mater. 2008 Aug;7(8):636-40. doi: 10.1038/nmat2203. Epub 2008 May 30. PubMed PMID: 18511938. 12: Zhang X, Do MD, Bilyk A. Chemical modification of wheat-protein-based natural polymers: formation of polymer networks with alkoxysilanes to modify molecular motions and enhance the material performance. Biomacromolecules. 2007 Jun;8(6):1881-9. Epub 2007 May 19. PubMed PMID: 17511502. 13: Mond JJ, Schaefer M, Smith J, Finkelman FD. Lyb-5- B cells of CBA/N mice can be induced to synthesize DNA by culture with insolubilized but not soluble anti-Ig. J Immunol. 1983 Nov;131(5):2107-9. PubMed PMID: 6195249. 14: Dosio F, Arpicco S, Adobati E, Canevari S, Brusa P, De Santis R, Parente D, Pignanelli P, Negri DR, Colnaghi MI, Cattel L. Role of cross-linking agents in determining the biochemical and pharmacokinetic properties of Mgr6-clavin immunotoxins. Bioconjug Chem. 1998 May-Jun;9(3):372-81. PubMed PMID: 9576812. 15: Doroodgar F, Niazi F, Sanginabadi A, Niazi S, Baradaran-Rafii A, Alinia C, Azargashb E, Ghoreishi M. Comparative analysis of the visual performance after implantation of the toric implantable collamer lens in stable keratoconus: a 4-year follow-up after sequential procedure (CXL+TICL implantation). BMJ Open Ophthalmol. 2017 Sep 28;2(1):e000090. doi: 10.1136/bmjophth-2017-000090. eCollection 2017. PubMed PMID: 29354720; PubMed Central PMCID: PMC5721648.