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MedKoo Cat#: 341334 | Name: Sulfoxaflor

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfoxaflor is a systemic insecticide which acts as an insect neurotoxin and is a member a class of chemicals called sulfoximines which act on the central nervous system of insects.

Chemical Structure

Sulfoxaflor
Sulfoxaflor
CAS#946578-00-3

Theoretical Analysis

MedKoo Cat#: 341334

Name: Sulfoxaflor

CAS#: 946578-00-3

Chemical Formula: C10H10F3N3OS

Exact Mass: 277.0497

Molecular Weight: 277.27

Elemental Analysis: C, 43.32; H, 3.64; F, 20.56; N, 15.16; O, 5.77; S, 11.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Sulfoxaflor; GF 2032; GF 2372; XDE 208.
IUPAC/Chemical Name
N-(methyloxido(1-(6-(trifluoromethyl)-3-pyridinyl)ethyl)-lambda4-sulfanylidene)cyanamide
InChi Key
ZVQOOHYFBIDMTQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H10F3N3OS/c1-7(18(2,17)16-6-14)8-3-4-9(15-5-8)10(11,12)13/h3-5,7H,1-2H3
SMILES Code
CC(S(=NC#N)(C)=O)c1cnc(C(F)(F)F)cc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hou SY, Wang YJ, Xue J, Li JX, Wang PS. [Research on control effect of sulfoxaflor and flonicamid on Lonicera japonica]. Zhongguo Zhong Yao Za Zhi. 2018 Jan;43(2):306-308. doi: 10.19540/j.cnki.cjcmm.20171030.007. Chinese. PubMed PMID: 29552848. 2: Zhen C, Miao L, Gao X. Sublethal effects of sulfoxaflor on biological characteristics and vitellogenin gene (AlVg) expression in the mirid bug, Apolygus lucorum (Meyer-Dür). Pestic Biochem Physiol. 2018 Jan;144:57-63. doi: 10.1016/j.pestbp.2017.11.008. Epub 2017 Nov 22. PubMed PMID: 29463409. 3: Casida JE. Neonicotinoids and Other Insect Nicotinic Receptor Competitive Modulators: Progress and Prospects. Annu Rev Entomol. 2018 Jan 7;63:125-144. doi: 10.1146/annurev-ento-020117-043042. PubMed PMID: 29324040. 4: Watson GB, Olson MB, Beavers KW, Loso MR, Sparks TC. Characterization of a nicotinic acetylcholine receptor binding site for sulfoxaflor, a new sulfoximine insecticide for the control of sap-feeding insect pests. Pestic Biochem Physiol. 2017 Nov;143:90-94. doi: 10.1016/j.pestbp.2017.09.003. Epub 2017 Sep 6. PubMed PMID: 29183616. 5: Hirata K, Jouraku A, Kuwazaki S, Kanazawa J, Iwasa T. The R81T mutation in the nicotinic acetylcholine receptor of Aphis gossypii is associated with neonicotinoid insecticide resistance with differential effects for cyano- and nitro-substituted neonicotinoids. Pestic Biochem Physiol. 2017 Nov;143:57-65. doi: 10.1016/j.pestbp.2017.09.009. Epub 2017 Sep 20. PubMed PMID: 29183611. 6: Alves TM, Marston ZP, MacRae IV, Koch RL. Effects of Foliar Insecticides on Leaf-Level Spectral Reflectance of Soybean. J Econ Entomol. 2017 Dec 5;110(6):2436-2442. doi: 10.1093/jee/tox250. PubMed PMID: 29029168. 7: Parys KA, Luttrell RG, Snodgrass GL, Portilla M, Copes JT. Longitudinal Measurements of Tarnished Plant Bug (Hemiptera: Miridae) Susceptibility to Insecticides in Arkansas, Louisiana, and Mississippi: Associations with Insecticide Use and Insect Control Recommendations. Insects. 2017 Oct 13;8(4). pii: E109. doi: 10.3390/insects8040109. PubMed PMID: 29027974; PubMed Central PMCID: PMC5746792. 8: Kabir MH, Abd El-Aty AM, Rahman MM, Chung HS, Lee HS, Kim SW, Chang HR, Shin HC, Shin SS, Shim JH. Chromatographic determination, decline dynamic and risk assessment of sulfoxaflor in Asian pear and oriental melon. Biomed Chromatogr. 2018 Mar;32(3). doi: 10.1002/bmc.4101. Epub 2017 Nov 8. PubMed PMID: 28975659. 9: Sullivan KM, Aggarwal M, Akins JM, Fabian E, Heylings JR, Raabe H, Shah PPV, Wiemann C, Peffer R. Dermal absorption for pesticide health risk assessment: Harmonization of study design and data reporting for North American Regulatory submissions. Regul Toxicol Pharmacol. 2017 Nov;90:197-205. doi: 10.1016/j.yrtph.2017.09.012. Epub 2017 Sep 12. PubMed PMID: 28916468. 10: Chen X, Li F, Chen A, Ma K, Liang P, Liu Y, Song D, Gao X. Both point mutations and low expression levels of the nicotinic acetylcholine receptor β1 subunit are associated with imidacloprid resistance in an Aphis gossypii (Glover) population from a Bt cotton field in China. Pestic Biochem Physiol. 2017 Sep;141:1-8. doi: 10.1016/j.pestbp.2016.11.004. Epub 2016 Nov 16. PubMed PMID: 28911734. 11: Zhu YC, Yao J, Adamczyk J, Luttrell R. Feeding toxicity and impact of imidacloprid formulation and mixtures with six representative pesticides at residue concentrations on honey bee physiology (Apis mellifera). PLoS One. 2017 Jun 7;12(6):e0178421. doi: 10.1371/journal.pone.0178421. eCollection 2017. PubMed PMID: 28591204; PubMed Central PMCID: PMC5462352. 12: de Little SC, Umina PA. Susceptibility of Australian Myzus persicae (Hemiptera: Aphididae) to Three Recently Registered Insecticides: Spirotetramat, Cyantraniliprole, and Sulfoxaflor. J Econ Entomol. 2017 Aug 1;110(4):1764-1769. doi: 10.1093/jee/tox132. PubMed PMID: 28475682. 13: Zhu YC, Yao J, Adamczyk J, Luttrell R. Synergistic toxicity and physiological impact of imidacloprid alone and binary mixtures with seven representative pesticides on honey bee (Apis mellifera). PLoS One. 2017 May 3;12(5):e0176837. doi: 10.1371/journal.pone.0176837. eCollection 2017. PubMed PMID: 28467462; PubMed Central PMCID: PMC5414993. 14: Wei X, Pan Y, Xin X, Zheng C, Gao X, Xi J, Shang Q. Cross-resistance pattern and basis of resistance in a thiamethoxam-resistant strain of Aphis gossypii Glover. Pestic Biochem Physiol. 2017 May;138:91-96. doi: 10.1016/j.pestbp.2017.03.007. Epub 2017 Mar 22. PubMed PMID: 28456311. 15: Kanishchev OS, Dolbier WR Jr. Ni/Ir-Catalyzed Photoredox Decarboxylative Coupling of S-Substituted Thiolactic Acids with Heteroaryl Bromides: Short Synthesis of Sulfoxaflor and Its SF(5) Analog. Chemistry. 2017 Jun 7;23(32):7677-7681. doi: 10.1002/chem.201701627. Epub 2017 May 15. PubMed PMID: 28411403. 16: Barbosa PRR, Michaud JP, Bain CL, Torres JB. Toxicity of three aphicides to the generalist predators Chrysoperla carnea (Neuroptera: Chrysopidae) and Orius insidiosus (Hemiptera: Anthocoridae). Ecotoxicology. 2017 Jul;26(5):589-599. doi: 10.1007/s10646-017-1792-5. Epub 2017 Mar 29. PubMed PMID: 28357620. 17: Pan F, Lu Y, Wang L. Toxicity and sublethal effects of sulfoxaflor on the red imported fire ant, Solenopsis invicta. Ecotoxicol Environ Saf. 2017 May;139:377-383. doi: 10.1016/j.ecoenv.2017.02.014. Epub 2017 Feb 23. PubMed PMID: 28189779. 18: Wang W, Wang S, Han G, Du Y, Wang J. Lack of cross-resistance between neonicotinoids and sulfoxaflor in field strains of Q-biotype of whitefly, Bemisia tabaci, from eastern China. Pestic Biochem Physiol. 2017 Mar;136:46-51. doi: 10.1016/j.pestbp.2016.08.005. Epub 2016 Aug 16. PubMed PMID: 28187830. 19: Yao FL, Zheng Y, Huang XY, Ding XL, Zhao JW, Desneux N, He YX, Weng QY. Dynamics of Bemisia tabaci biotypes and insecticide resistance in Fujian province in China during 2005-2014. Sci Rep. 2017 Jan 23;7:40803. doi: 10.1038/srep40803. PubMed PMID: 28112233; PubMed Central PMCID: PMC5256031. 20: Colares F, Michaud JP, Bain CL, Torres JB. Relative Toxicity of Two Aphicides to Hippodamia convergens (Coleoptera: Coccinellidae): Implications for Integrated Management of Sugarcane Aphid, Melanaphis sacchari (Hemiptera: Aphididae). J Econ Entomol. 2017 Feb 1;110(1):52-58. doi: 10.1093/jee/tow265. PubMed PMID: 28039423.