Synonym
Dactylocyclinone; Sch 34164;
IUPAC/Chemical Name
2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-7-chloro-4-(dimethylamino)-1,11-dioxo-3,4a,6,10,12,12a-hexahydroxy-8-methoxy-, (4R-(4-alpha,4a-alpha,5a-alpha,6-beta,12-alpha))-
InChi Key
BCQXQSRYTBJTTG-XDXBOZIESA-N
InChi Code
InChI=1S/C22H23ClN2O10/c1-25(2)17-16(29)12(20(24)32)19(31)22(34)18(30)9-6(5-21(17,22)33)14(27)11-10(15(9)28)7(26)4-8(35-3)13(11)23/h4,6,14,17,26-27,29-30,33-34H,5H2,1-3H3,(H2,24,32)/t6-,14-,17+,21+,22?/m0/s1
SMILES Code
O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2(O)C[C@]3([H])[C@H](O)C4=C(C(C3=C(O)C21O)=O)C(O)=CC(OC)=C4Cl)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
510.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Devasthale PV, Mitscher LA, Telikepalli H, Vander Velde D, Zou JY, Ax HA, Tymiak AA. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. III. Absolute stereochemistry of the dactylocyclines. J Antibiot (Tokyo). 1992 Dec;45(12):1907-13. PubMed PMID: 1490882.
2: Cacciapuoti A, Moss EL Jr, Menzel F Jr, Cramer CA, Weiss W, Loebenberg D, Hare RS, Miller GH. In vitro and in vivo characterization of novel 8-methoxy derivatives of chlortetracycline. J Antibiot (Tokyo). 1987 Oct;40(10):1426-30. PubMed PMID: 3680008.
3: Tymiak AA, Ax HA, Bolgar MS, Kahle AD, Porubcan MA, Andersen NH. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. II. Structure elucidation. J Antibiot (Tokyo). 1992 Dec;45(12):1899-906. PubMed PMID: 1490881.
4: Patel M, Gullo VP, Hegde VR, Horan AC, Marquez JA, Vaughan R, Puar MS, Miller GH. A new tetracycline antibiotic from a Dactylosporangium species. Fermentation, isolation and structure elucidation. J Antibiot (Tokyo). 1987 Oct;40(10):1414-8. PubMed PMID: 3680006.
