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MedKoo Cat#: 581195 | Name: Dactimicin sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dactimicin sulfate, also known as Antibiotic SF 2052 sulfate. Dactimicin is a new aminoglycoside, in vitro activity, post-antibiotic effect and interaction with other antibiotics.

Chemical Structure

Dactimicin sulfate
Dactimicin sulfate
CAS#73245-91-7

Theoretical Analysis

MedKoo Cat#: 581195

Name: Dactimicin sulfate

CAS#: 73245-91-7

Chemical Formula: C18H40N6O14S2

Exact Mass: 628.2044

Molecular Weight: 628.67

Elemental Analysis: C, 34.39; H, 6.41; N, 13.37; O, 35.63; S, 10.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dactimicin sulfate; Antibiotic SF 2052 sulfate; SF-2052 sulfate;
IUPAC/Chemical Name
N-(4-amino-3-((3-amino-6-(1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxy-6-methoxycyclohexyl)-2-formimidamido-N-methylacetamide bis(sulfate)
InChi Key
ZFWIVAVUSGOMQJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H36N6O6.2H2O4S/c1-8(20)10-5-4-9(21)18(29-10)30-16-12(22)14(26)17(28-3)13(15(16)27)24(2)11(25)6-23-7-19;2*1-5(2,3)4/h7-10,12-18,26-27H,4-6,20-22H2,1-3H3,(H2,19,23);2*(H2,1,2,3,4)
SMILES Code
CC(C1CCC(C(O1)OC2C(C(C(C(C2O)N(C)C(=O)CNC=N)OC)O)N)N)N.OS(=O)(=O)O.OS(=O)(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 628.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Paglia P, Molinari G, Pesce A, Debbia EA. Dactimicin, a new aminoglycoside: in vitro activity, post-antibiotic effect and interaction with other antibiotics. Eur J Clin Microbiol Infect Dis. 1989 Jul;8(7):639-43. PubMed PMID: 2506028. 2: Ohba K, Tsuruoka T, Mizutani K, Kato N, Omoto S, Ezaki N, Inouye S, Niida T, Watanabe K. Studies on a new aminoglycoside antibiotic, dactimicin. II. Isolation, structure and chemical degradation. J Antibiot (Tokyo). 1981 Sep;34(9):1090-100. PubMed PMID: 7328051. 3: Bergan T. Susceptibility of clinical isolates to dactimicin and gentamicin. Drugs Exp Clin Res. 1989;15(3):109-12. PubMed PMID: 2752907. 4: Stefani S, Nicoletti G, Russo G, Toscano MA. First microbiological approach to dactimicin, a novel aminoglycoside antibiotic. Drugs Exp Clin Res. 1987;13(12):727-9. PubMed PMID: 3447875. 5: Inouye S, Hara T, Matsuhashi Y, Kitasato I. Antimicrobial activity of dactimicin in vitro compared with that of dibekacin, netilmicin, sisomicin and micronomicin. Drugs Exp Clin Res. 1989;15(10):455-63. PubMed PMID: 2632214. 6: Yokota M, Sakamoto K, Inouye S, Akiyoshi M, Kitasato I. Ototoxic effects of a pseudodisaccharide aminoglycoside antibiotic, dactimicin, on the inner ears of guinea pigs. Chemotherapy. 1989;35(6):431-40. PubMed PMID: 2612232. 7: Stefani S, Debbia EA, Schito GC, Russo G. Microbiological characterization of dactimicin: antibacterial activity towards gram-positive and gram-negative bacteria. Drugs Exp Clin Res. 1989;15(3):119-23. PubMed PMID: 2752910. 8: Fraschini F, Scaglione F, Nebuloni R, Falchi M, Balsamo V, Cattaneo G. Pharmacokinetics of dactimicin in rats. Drugs Exp Clin Res. 1989;15(11-12):541-3. PubMed PMID: 2637794. 9: Felmingham D, Jones K. In vitro activity of dactimicin and other aminoglycosides against bacteria producing aminoglycoside-modifying enzymes. Drugs Exp Clin Res. 1989;15(3):133-6. PubMed PMID: 2752913. 10: Gu JW, Neu HC. In vitro activity of dactimicin, a novel pseudodisaccharide aminoglycoside, compared with activities of other aminoglycosides. Antimicrob Agents Chemother. 1989 Nov;33(11):1998-2003. PubMed PMID: 2514625; PubMed Central PMCID: PMC172802. 11: Debbia E, Schito GC, Stefani S, Nicoletti G. Bactericidal activity and post-antibiotic effect in vitro of dactimicin alone and in combination with other drugs. J Chemother. 1989 Jul;1(4 Suppl):187-8. PubMed PMID: 16312361. 12: Bonadio M, Maccanti O, Giovannini L, Bertelli AA, Scalori V, Alessandrì MG, Bertelli A. Comparative nephrotoxicity and tissue accumulation of dactimicin, amikacin and gentamicin. Drugs Exp Clin Res. 1987;13(12):747-50. PubMed PMID: 3447878. 13: Debbia EA, Schito GC, Stefani S, Nicoletti G. In vitro bactericidal activity and post-antibiotic effect of dactimicin, a new aminoglycoside, alone and in combination with other antibiotics. Drugs Exp Clin Res. 1989;15(3):125-8. PubMed PMID: 2752911. 14: Nord CE, Lahnborg G. Efficacy of dactimicin in the treatment of experimentally induced intra-abdominal infections. Drugs Exp Clin Res. 1989;15(3):115-8. PubMed PMID: 2752909. 15: Nord CE, Kager L. Antimicrobial activity of dactimicin against aerobic and anaerobic bacteria isolated from intra-abdominal infections. Drugs Exp Clin Res. 1989;15(3):113-4. PubMed PMID: 2752908. 16: Matsuhashi Y, Yoshida T, Hara T, Kazuno Y, Inouye S. In vitro and in vivo antibacterial activities of dactimicin, a novel pseudodisaccharide aminoglycoside, compared with those of other aminoglycoside antibiotics. Antimicrob Agents Chemother. 1985 Apr;27(4):589-94. PubMed PMID: 3873901; PubMed Central PMCID: PMC180101. 17: Bertelli A, Bertelli AA. Dactimicin: a most interesting member of a new class of aminoglycosides. Drugs Exp Clin Res. 1989;15(3):105-7. Review. PubMed PMID: 2666073. 18: Omoto S, Yoshida T, Kurebe M, Inouye S. Dactimicin, a new, less toxic aminoglycoside antibiotic active against resistant bacteria. Drugs Exp Clin Res. 1987;13(12):719-25. PubMed PMID: 3447874. 19: Nord CE, Lahnborg G. Efficacy of dactimicin plus clindamycin compared with gentamicin plus clindamycin in the treatment of experimental intra-abdominal infections in rats. Drugs Exp Clin Res. 1990;16(8):403-6. PubMed PMID: 2097144. 20: Gómez-Lus R, Gómez-Lus S, Goñi MP, Rivera MJ, Martín C, Rubio-Calvo MC. Stability of dactimicin to aminoglycoside-modifying enzymes produced by 341 bacterial clinical isolates. Drugs Exp Clin Res. 1989;15(3):129-32. PubMed PMID: 2752912.