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MedKoo Cat#: 562580 | Name: AMG8163

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMG8163 is a vanilloid receptor TRPV1 antagonist.

Chemical Structure

AMG8163
AMG8163
CAS#659731-59-6

Theoretical Analysis

MedKoo Cat#: 562580

Name: AMG8163

CAS#: 659731-59-6

Chemical Formula: C25H22F3N5O4S

Exact Mass: 545.1345

Molecular Weight: 545.53

Elemental Analysis: C, 55.04; H, 4.06; F, 10.45; N, 12.84; O, 11.73; S, 5.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AMG8163; AMG-8163; AMG 8163;
IUPAC/Chemical Name
N-[2-[6-[[2-(Acetylamino)-4-benzothiazolyl]oxy]-4-pyrimidinyl]-5-(trifluoromethyl)phenyl]-carbamic acid 1,1-dimethylethyl ester
InChi Key
JXKLZZJMXYNAFG-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H22F3N5O4S/c1-13(34)31-22-33-21-18(6-5-7-19(21)38-22)36-20-11-16(29-12-30-20)15-9-8-14(25(26,27)28)10-17(15)32-23(35)37-24(2,3)4/h5-12H,1-4H3,(H,32,35)(H,31,33,34)
SMILES Code
O=C(OC(C)(C)C)NC1=CC(C(F)(F)F)=CC=C1C2=NC=NC(OC3=C4N=C(NC(C)=O)SC4=CC=C3)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 545.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gavva NR, Bannon AW, Hovland DN Jr, Lehto SG, Klionsky L, Surapaneni S, Immke DC, Henley C, Arik L, Bak A, Davis J, Ernst N, Hever G, Kuang R, Shi L, Tamir R, Wang J, Wang W, Zajic G, Zhu D, Norman MH, Louis JC, Magal E, Treanor JJ. Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther. 2007 Oct;323(1):128-37. Epub 2007 Jul 25. PubMed PMID: 17652633. 2: Gavva NR, Bannon AW, Surapaneni S, Hovland DN Jr, Lehto SG, Gore A, Juan T, Deng H, Han B, Klionsky L, Kuang R, Le A, Tamir R, Wang J, Youngblood B, Zhu D, Norman MH, Magal E, Treanor JJ, Louis JC. The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci. 2007 Mar 28;27(13):3366-74. PubMed PMID: 17392452.