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MedKoo Cat#: 562512 | Name: SPD-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SPD-2 is a photo-controllable hydrogen sulfide donor applicable in live cells.

Chemical Structure

SPD-2
SPD-2
CAS#1643781-40-1

Theoretical Analysis

MedKoo Cat#: 562512

Name: SPD-2

CAS#: 1643781-40-1

Chemical Formula: C34H26O8S

Exact Mass: 594.1348

Molecular Weight: 594.63

Elemental Analysis: C, 68.68; H, 4.41; O, 21.52; S, 5.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SPD-2; SPD 2; SPD2;
IUPAC/Chemical Name
2,6-Dimethyl-2,6-di(9-oxo-9H-xanthen-2-yl)-4-thia-heptanedioic acid
InChi Key
HLYJZNLEINAZNN-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H26O8S/c1-33(31(37)38,19-11-13-27-23(15-19)29(35)21-7-3-5-9-25(21)41-27)17-43-18-34(2,32(39)40)20-12-14-28-24(16-20)30(36)22-8-4-6-10-26(22)42-28/h3-16H,17-18H2,1-2H3,(H,37,38)(H,39,40)
SMILES Code
O=C(O)C(C1=CC(C2=O)=C(OC3=C2C=CC=C3)C=C1)(C)CSCC(C4=CC(C5=O)=C(OC6=C5C=CC=C6)C=C4)(C)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 594.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Riparbelli MG, Persico V, Gottardo M, Callaini G. The developing Drosophila eye - a new model to study centriole reduction. J Cell Sci. 2018 Feb 22;131(4). pii: jcs211441. doi: 10.1242/jcs.211441. PubMed PMID: 29361550. 2: Woodruff JB, Ferreira Gomes B, Widlund PO, Mahamid J, Honigmann A, Hyman AA. The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin. Cell. 2017 Jun 1;169(6):1066-1077.e10. doi: 10.1016/j.cell.2017.05.028. PubMed PMID: 28575670. 3: Sugioka K, Hamill DR, Lowry JB, McNeely ME, Enrick M, Richter AC, Kiebler LE, Priess JR, Bowerman B. Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation. Elife. 2017 Jan 16;6. pii: e20353. doi: 10.7554/eLife.20353. PubMed PMID: 28092264; PubMed Central PMCID: PMC5342823. 4: Verdier P, Morthorst SK, Pedersen LB. Targeting of ASH Domain-Containing Proteins to the Centrosome. Methods Mol Biol. 2016;1454:15-33. doi: 10.1007/978-1-4939-3789-9_2. PubMed PMID: 27514913. 5: Antunes E, Cruz CF, Azoia NG, Cavaco-Paulo A. Insights on the mechanical behavior of keratin fibrils. Int J Biol Macromol. 2016 Aug;89:477-83. doi: 10.1016/j.ijbiomac.2016.05.018. Epub 2016 May 6. PubMed PMID: 27164495. 6: Conduit PT, Wainman A, Novak ZA, Weil TT, Raff JW. Re-examining the role of Drosophila Sas-4 in centrosome assembly using two-colour-3D-SIM FRAP. Elife. 2015 Nov 4;4. pii: e08483. doi: 10.7554/eLife.08483. PubMed PMID: 26530814; PubMed Central PMCID: PMC4631861. 7: Conduit PT, Raff JW. Different Drosophila cell types exhibit differences in mitotic centrosome assembly dynamics. Curr Biol. 2015 Aug 3;25(15):R650-1. doi: 10.1016/j.cub.2015.05.061. PubMed PMID: 26241137; PubMed Central PMCID: PMC4533225. 8: Woodruff JB, Hyman AA. Method: In vitro analysis of pericentriolar material assembly. Methods Cell Biol. 2015;129:369-82. doi: 10.1016/bs.mcb.2015.04.006. Epub 2015 Jun 19. PubMed PMID: 26175448. 9: Richens JH, Barros TP, Lucas EP, Peel N, Pinto DM, Wainman A, Raff JW. The Drosophila Pericentrin-like-protein (PLP) cooperates with Cnn to maintain the integrity of the outer PCM. Biol Open. 2015 Jul 8;4(8):1052-61. doi: 10.1242/bio.012914. PubMed PMID: 26157019; PubMed Central PMCID: PMC4542290. 10: Yang R, Feldman JL. SPD-2/CEP192 and CDK Are Limiting for Microtubule-Organizing Center Function at the Centrosome. Curr Biol. 2015 Jul 20;25(14):1924-31. doi: 10.1016/j.cub.2015.06.001. Epub 2015 Jun 25. PubMed PMID: 26119750. 11: Baumbach J, Novak ZA, Raff JW, Wainman A. Dissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivo. PLoS Genet. 2015 May 28;11(5):e1005261. doi: 10.1371/journal.pgen.1005261. eCollection 2015 May. PubMed PMID: 26020779; PubMed Central PMCID: PMC4447278. 12: Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA. Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro. Science. 2015 May 15;348(6236):808-12. doi: 10.1126/science.aaa3923. PubMed PMID: 25977552; PubMed Central PMCID: PMC5039038. 13: Fukushima N, Ieda N, Kawaguchi M, Sasakura K, Nagano T, Hanaoka K, Miyata N, Nakagawa H. Development of photo-controllable hydrogen sulfide donor applicable in live cells. Bioorg Med Chem Lett. 2015 Jan 15;25(2):175-8. doi: 10.1016/j.bmcl.2014.11.084. Epub 2014 Dec 8. PubMed PMID: 25499432. 14: Lu Y, Roy R. Centrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegans. PLoS One. 2014 Oct 31;9(10):e110958. doi: 10.1371/journal.pone.0110958. eCollection 2014. PubMed PMID: 25360893; PubMed Central PMCID: PMC4215990. 15: Wueseke O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA. The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix. Mol Biol Cell. 2014 Oct 1;25(19):2984-92. doi: 10.1091/mbc.E13-09-0514. Epub 2014 Aug 7. PubMed PMID: 25103243; PubMed Central PMCID: PMC4230587. 16: Schou KB, Morthorst SK, Christensen ST, Pedersen LB. Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8. Cilia. 2014 Jun 18;3:6. doi: 10.1186/2046-2530-3-6. eCollection 2014. PubMed PMID: 25018876; PubMed Central PMCID: PMC4094338. 17: Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R, Svergun DI, Round A, Oegema K, Dong G. Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases. Structure. 2014 Aug 5;22(8):1090-1104. doi: 10.1016/j.str.2014.05.009. Epub 2014 Jun 26. PubMed PMID: 24980795; PubMed Central PMCID: PMC4126857. 18: Sun J, Yang Y, Wang X, Yu Z, Zhang T, Song J, Zhao H, Wen J, Du Y, Lau WY, Zhang Y. Meta-analysis of the efficacies of extended and standard pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas. World J Surg. 2014 Oct;38(10):2708-15. doi: 10.1007/s00268-014-2633-9. Review. PubMed PMID: 24912627. 19: Shimanovskaya E, Qiao R, Lesigang J, Dong G. The SAS-5 N-terminal domain is a tetramer, with implications for centriole assembly in C. elegans. Worm. 2013 Jul 1;2(3):e25214. doi: 10.4161/worm.25214. Epub 2013 May 31. PubMed PMID: 24778935; PubMed Central PMCID: PMC3875647. 20: Ma B, Yue K, Chen L, Tian X, Ru Q, Gan Y, Wang D, Jin G, Li C. L-stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement. Neurosci Lett. 2014 Jan 24;559:67-71. doi: 10.1016/j.neulet.2013.10.066. Epub 2013 Nov 20. PubMed PMID: 24269875.