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MedKoo Cat#: 527868 | Name: BLT-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BLT-1 is a novel inhibitor of scavenger receptor BI (SR-BI).

Chemical Structure

BLT-1
BLT-1
CAS#321673-30-7

Theoretical Analysis

MedKoo Cat#: 527868

Name: BLT-1

CAS#: 321673-30-7

Chemical Formula: C12H23N3S

Exact Mass: 241.1613

Molecular Weight: 241.40

Elemental Analysis: C, 59.71; H, 9.60; N, 17.41; S, 13.28

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
25mg USD 485.00 2 Weeks
50mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
BLT1; BLT 1; BLT-1; Block Lipid Transport-1
IUPAC/Chemical Name
2-Hexyl-1-cyclopentanone thiosemicarbazone
InChi Key
OWGUSBISUVLUJF-KAMYIIQDSA-N
InChi Code
InChI=1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11-
SMILES Code
CCCCCCC(CCC/1)C1=N/NC(N)=S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 241.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Baicalin promotes cholesterol efflux by regulating the expression of SR-BI in macrophages. Exp Ther Med. 2016 Dec;12(6):4113-4120. doi: 10.3892/etm.2016.3884. Epub 2016 Nov 8. PubMed PMID: 28105139; PubMed Central PMCID: PMC5228540. 5: Yashaswini PS, Sadashivaiah B, Ramaprasad TR, Singh SA. In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans. J Nutr Biochem. 2017 Mar;41:151-157. doi: 10.1016/j.jnutbio.2016.12.010. Epub 2016 Dec 29. PubMed PMID: 28095362. 6: Freire MO, Dalli J, Serhan CN, Van Dyke TE. Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes. J Immunol. 2017 Jan 15;198(2):718-728. doi: 10.4049/jimmunol.1601543. Epub 2016 Dec 19. PubMed PMID: 27994073; PubMed Central PMCID: PMC5224973. 7: Cox JV, Abdelrahman YM, Peters J, Naher N, Belland RJ. Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth. Cell Microbiol. 2016 Mar;18(3):305-18. doi: 10.1111/cmi.12523. Epub 2015 Oct 16. PubMed PMID: 26381674. 8: Lino M, Farr S, Baker C, Fuller M, Trigatti B, Adeli K. Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G350-9. doi: 10.1152/ajpgi.00086.2015. Epub 2015 Jul 2. PubMed PMID: 26138463. 9: Tu Y, Schuchardt M, Toelle M, Zidek W, Van Der Giet M. 2B.08: SERUM AMYLOID A: INFLAMMATORY EFFECTS ON MACROPHAGES. J Hypertens. 2015 Jun;33 Suppl 1:e24. doi: 10.1097/01.hjh.0000467413.32526.6f. PubMed PMID: 26102766. 10: Faloon PW, Dockendorff C, Germain A, Yu M, Nag PP, Youngsaye W, Bennion M, Lam G, Paterson C, Dandapani S, Munoz B, Perez J, Palmer M, Nieland TJF, Krieger M, Schreiber SL. A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 2. 2011 Dec 15 [updated 2014 Sep 18]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK133438/ PubMed PMID: 23658957. 11: Faloon PW, Dockendorff C, Youngsaye W, Yu M, Nag PP, Lewis TA, Bennion M, Paterson C, Lam G, Dandapani S, Munoz B, Perez J, Palmer M, Nieland TJF, Krieger M, Schreiber SL. A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1. 2011 Dec 15 [updated 2014 Sep 18]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK133420/ PubMed PMID: 23658945. 12: Liu FF, Wu X, Zhang Y, Wang Y, Jiang F. TRAIL/DR5 signaling promotes macrophage foam cell formation by modulating scavenger receptor expression. PLoS One. 2014 Jan 22;9(1):e87059. doi: 10.1371/journal.pone.0087059. eCollection 2014. PubMed PMID: 24466325; PubMed Central PMCID: PMC3899365. 13: Sato Y, Kondo Y, Sumi M, Takekuma Y, Sugawara M. Intracellular uptake mechanism of lutein in retinal pigment epithelial cells. J Pharm Pharm Sci. 2013;16(3):494-501. PubMed PMID: 24021296. 14: Sharma RK, Chheda Z, Jala VR, Haribabu B. Expression of leukotriene B₄ receptor-1 on CD8⁺ T cells is required for their migration into tumors to elicit effective antitumor immunity. J Immunol. 2013 Sep 15;191(6):3462-70. doi: 10.4049/jimmunol.1300967. Epub 2013 Aug 19. PubMed PMID: 23960231; PubMed Central PMCID: PMC3815560. 15: Chen YC, Lin YH, Wang SH, Lin SP, Shung KK, Wu CC. Monitoring tissue inflammation and responses to drug treatments in early stages of mice bone fracture using 50 MHz ultrasound. Ultrasonics. 2014 Jan;54(1):177-86. doi: 10.1016/j.ultras.2013.06.008. Epub 2013 Jul 11. PubMed PMID: 23871514; PubMed Central PMCID: PMC4047674. 16: Ochkur SI, Protheroe CA, Li W, Colbert DC, Zellner KR, Shen HH, Luster AD, Irvin CG, Lee JJ, Lee NA. Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation. Am J Respir Cell Mol Biol. 2013 Dec;49(6):1074-84. doi: 10.1165/rcmb.2013-0009OC. PubMed PMID: 23859654; PubMed Central PMCID: PMC3931112. 17: Saha S, Graessler J, Bornstein SR, Schwarz PE, Kopprasch S. Stimulation of phagocyte adhesion to endothelial cells by modified VLDL and HDL requires scavenger receptor BI. Mol Cell Biochem. 2013 Nov;383(1-2):21-8. doi: 10.1007/s11010-013-1749-9. Epub 2013 Jul 14. PubMed PMID: 23852455. 18: Faloon PW, Dockendorff C, Yu M, Bennion M, Johnston S, Negri J, Dandapani S, Munoz B, Perez JR, Palmer M, Penman M, Nieland TJF, Krieger M, Schreiber SL. A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake - Probe 3. 2012 Apr 16 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK143554/ PubMed PMID: 23762924. 19: Chouinard F, Turcotte C, Guan X, Larose MC, Poirier S, Bouchard L, Provost V, Flamand L, Grandvaux N, Flamand N. 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV. J Leukoc Biol. 2013 Feb;93(2):267-76. doi: 10.1189/jlb.0412200. Epub 2012 Dec 12. PubMed PMID: 23242611; PubMed Central PMCID: PMC4995105. 20: Yu M, Lau TY, Carr SA, Krieger M. Contributions of a disulfide bond and a reduced cysteine side chain to the intrinsic activity of the high-density lipoprotein receptor SR-BI. Biochemistry. 2012 Dec 18;51(50):10044-55. doi: 10.1021/bi301203x. Epub 2012 Dec 10. PubMed PMID: 23205738; PubMed Central PMCID: PMC3566775.