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MedKoo Cat#: 341305 | Name: Gentisin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gentisin is a biochemical.

Chemical Structure

Gentisin
Gentisin
CAS#437-50-3

Theoretical Analysis

MedKoo Cat#: 341305

Name: Gentisin

CAS#: 437-50-3

Chemical Formula: C14H10O5

Exact Mass: 258.0528

Molecular Weight: 258.23

Elemental Analysis: C, 65.12; H, 3.90; O, 30.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Gentisin; BRN 0384788; BRN-0384788; BRN0384788.
IUPAC/Chemical Name
1,7-Dihydroxy-3-methoxyxanthen-9-one
InChi Key
XOXYHGOIRWABTC-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10O5/c1-18-8-5-10(16)13-12(6-8)19-11-3-2-7(15)4-9(11)14(13)17/h2-6,15-16H,1H3
SMILES Code
O=C1C2=C(OC3=C1C=C(O)C=C3)C=C(OC)C=C2O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 258.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yin C, Xie L, Guo Y. Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections. Microb Pathog. 2018 Jan;114:25-28. doi: 10.1016/j.micpath.2017.10.049. Epub 2017 Oct 27. PubMed PMID: 29111322. 2: Amakura Y, Yoshimura M, Morimoto S, Yoshida T, Tada A, Ito Y, Yamazaki T, Sugimoto N, Akiyama H. Chromatographic Evaluation and Characterization of Components of Gentian Root Extract Used as Food Additives. Chem Pharm Bull (Tokyo). 2016;64(1):78-82. doi: 10.1248/cpb.c15-00776. PubMed PMID: 26726749. 3: Waltenberger B, Liu R, Atanasov AG, Schwaiger S, Heiss EH, Dirsch VM, Stuppner H. Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation. Molecules. 2015 Nov 13;20(11):20381-90. doi: 10.3390/molecules201119703. PubMed PMID: 26580586. 4: Kesavan R, Potunuru UR, Nastasijević B, T A, Joksić G, Dixit M. Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts. PLoS One. 2013 Apr 18;8(4):e61393. doi: 10.1371/journal.pone.0061393. Print 2013. PubMed PMID: 23637826; PubMed Central PMCID: PMC3630200. 5: Wani BA, Ramamoorthy D, Rather MA, Arumugam N, Qazi AK, Majeed R, Hamid A, Ganie SA, Ganai BA, Anand R, Gupta AP. Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (ΔΨm) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents. Phytomedicine. 2013 Jun 15;20(8-9):723-33. doi: 10.1016/j.phymed.2013.01.011. Epub 2013 Mar 1. PubMed PMID: 23453831. 6: Citová I, Ganzera M, Stuppner H, Solich P. Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis. J Sep Sci. 2008 Jan;31(1):195-200. PubMed PMID: 18064621. 7: Aberham A, Schwaiger S, Stuppner H, Ganzera M. Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC-MS. J Pharm Biomed Anal. 2007 Nov 5;45(3):437-42. Epub 2007 Jul 10. PubMed PMID: 17697760. 8: Kijjoa A, Gonzalez MJ, Pinto MM, Silva AM, Anantachoke C, Herz W. Xanthones from Calophyllum teysmannii var. inophylloide. Phytochemistry. 2000 Dec;55(7):833-6. PubMed PMID: 11190405. 9: Matsushima T, Araki A, Yagame O, Muramatsu M, Koyama K, Ohsawa K, Natori S, Tomimori H. Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637. Mutat Res. 1985 Jun-Jul;150(1-2):141-6. PubMed PMID: 3889613. 10: Morimoto I, Nozaka T, Watanabe F, Ishino M, Hirose Y, Okitsu T. Mutagenic activities of gentisin and isogentisin from Gentianae radix (Gentianaceae). Mutat Res. 1983 Feb;116(2):103-17. PubMed PMID: 6338357. 11: ENGEL BG, BRZESKI W. [Not Available]. Helv Chim Acta. 1947 Oct 15;30(6):1472-8. Undetermined Language. PubMed PMID: 20272044.

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