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MedKoo Cat#: 341296 | Name: Isoxaben

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoxaben is a biochemical.

Chemical Structure

Isoxaben
Isoxaben
CAS#82558-50-7

Theoretical Analysis

MedKoo Cat#: 341296

Name: Isoxaben

CAS#: 82558-50-7

Chemical Formula: C18H24N2O4

Exact Mass: 332.1736

Molecular Weight: 332.40

Elemental Analysis: C, 65.04; H, 7.28; N, 8.43; O, 19.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Isoxaben； EL 107； NA 8318.
IUPAC/Chemical Name
Benzamide, 2,6-dimethoxy-N-(3-(1-ethyl-1-methylpropyl)-5-isoxazolyl)-
InChi Key
PMHURSZHKKJGBM-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H24N2O4/c1-6-18(3,7-2)14-11-15(24-20-14)19-17(21)16-12(22-4)9-8-10-13(16)23-5/h8-11H,6-7H2,1-5H3,(H,19,21)
SMILES Code
O=C(NC1=CC(C(C)(CC)CC)=NO1)C2=C(OC)C=CC=C2OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 332.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Le PY, Jeon HW, Kim MH, Park EJ, Lee H, Hwang I, Han KH, Ko JH. Gain-of-function mutation of AtDICE1, encoding a putative endoplasmic reticulum-localized membrane protein, causes defects in anisotropic cell elongation by disturbing cell wall integrity in Arabidopsis. Ann Bot. 2018 Apr 5. doi: 10.1093/aob/mcy049. [Epub ahead of print] PubMed PMID: 29659701. 2: Gigli Bisceglia N, Savatin DV, Cervone F, Engelsdorf T, De Lorenzo G. Loss of the Arabidopsis Protein Kinases ANPs Affects Root Cell Wall Composition, and Triggers the Cell Wall Damage Syndrome. Front Plant Sci. 2018 Jan 22;8:2234. doi: 10.3389/fpls.2017.02234. eCollection 2017. PubMed PMID: 29403509; PubMed Central PMCID: PMC5786559. 3: Tran ML, McCarthy TW, Sun H, Wu SZ, Norris JH, Bezanilla M, Vidali L, Anderson CT, Roberts AW. Direct observation of the effects of cellulose synthesis inhibitors using live cell imaging of Cellulose Synthase (CESA) in Physcomitrella patens. Sci Rep. 2018 Jan 15;8(1):735. doi: 10.1038/s41598-017-18994-4. PubMed PMID: 29335590; PubMed Central PMCID: PMC5768717. 4: Brabham C, Stork J, Barrett M, DeBolt S. Grass cell walls have a role in the inherent tolerance of grasses to the cellulose biosynthesis inhibitor isoxaben. Pest Manag Sci. 2018 Apr;74(4):878-884. doi: 10.1002/ps.4779. Epub 2017 Dec 28. PubMed PMID: 29087620. 5: Tolmie F, Poulet A, McKenna J, Sassmann S, Graumann K, Deeks M, Runions J. The cell wall of Arabidopsis thaliana influences actin network dynamics. J Exp Bot. 2017 Jul 20;68(16):4517-4527. doi: 10.1093/jxb/erx269. PubMed PMID: 28981774. 6: Merz D, Richter J, Gonneau M, Sanchez-Rodriguez C, Eder T, Sormani R, Martin M, Hématy K, Höfte H, Hauser MT. T-DNA alleles of the receptor kinase THESEUS1 with opposing effects on cell wall integrity signaling. J Exp Bot. 2017 Jul 20;68(16):4583-4593. doi: 10.1093/jxb/erx263. PubMed PMID: 28981771. 7: Largo-Gosens A, de Castro M, Alonso-Simón A, García-Angulo P, Acebes JL, Encina A, Álvarez JM. Quinclorac-habituation of bean (Phaseolus vulgaris) cultured cells is related to an increase in their antioxidant capacity. Plant Physiol Biochem. 2016 Oct;107:257-263. doi: 10.1016/j.plaphy.2016.06.011. Epub 2016 Jun 8. PubMed PMID: 27318799. 8: Tegg RS, Shabala S, Cuin TA, Wilson CR. Mechanisms of thaxtomin A-induced root toxicity revealed by a thaxtomin A sensitive Arabidopsis mutant (ucu2-2/gi-2). Plant Cell Rep. 2016 Feb;35(2):347-56. doi: 10.1007/s00299-015-1888-4. Epub 2015 Oct 30. PubMed PMID: 26518425. 9: Raggi S, Ferrarini A, Delledonne M, Dunand C, Ranocha P, De Lorenzo G, Cervone F, Ferrari S. The Arabidopsis Class III Peroxidase AtPRX71 Negatively Regulates Growth under Physiological Conditions and in Response to Cell Wall Damage. Plant Physiol. 2015 Dec;169(4):2513-25. doi: 10.1104/pp.15.01464. Epub 2015 Oct 14. PubMed PMID: 26468518; PubMed Central PMCID: PMC4677920. 10: Moon EK, Hong Y, Chung DI, Goo YK, Kong HH. Potential Value of Cellulose Synthesis Inhibitors Combined With PHMB in the Treatment of Acanthamoeba Keratitis. Cornea. 2015 Dec;34(12):1593-8. doi: 10.1097/ICO.0000000000000642. PubMed PMID: 26426333. 11: Griffiths JS, Šola K, Kushwaha R, Lam P, Tateno M, Young R, Voiniciuc C, Dean G, Mansfield SD, DeBolt S, Haughn GW. Unidirectional movement of cellulose synthase complexes in Arabidopsis seed coat epidermal cells deposit cellulose involved in mucilage extrusion, adherence, and ray formation. Plant Physiol. 2015 Jun;168(2):502-20. doi: 10.1104/pp.15.00478. Epub 2015 Apr 29. PubMed PMID: 25926481; PubMed Central PMCID: PMC4453796. 12: Worden N, Wilkop TE, Esteve VE, Jeannotte R, Lathe R, Vernhettes S, Weimer B, Hicks G, Alonso J, Labavitch J, Persson S, Ehrhardt D, Drakakaki G. CESA TRAFFICKING INHIBITOR inhibits cellulose deposition and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1. Plant Physiol. 2015 Feb;167(2):381-93. doi: 10.1104/pp.114.249003. Epub 2014 Dec 22. PubMed PMID: 25535279; PubMed Central PMCID: PMC4326758. 13: Raeppel C, Fabritius M, Nief M, Appenzeller BM, Briand O, Tuduri L, Millet M. Analysis of airborne pesticides from different chemical classes adsorbed on Radiello® Tenax® passive tubes by thermal-desorption-GC/MS. Environ Sci Pollut Res Int. 2015 Feb;22(4):2726-34. doi: 10.1007/s11356-014-3534-z. Epub 2014 Sep 11. PubMed PMID: 25205153. 14: Flessner ML, Wehtje GR, McElroy JS, Howe JA. Methiozolin sorption and mobility in sand-based root zones. Pest Manag Sci. 2015 Aug;71(8):1133-40. doi: 10.1002/ps.3896. Epub 2014 Oct 18. PubMed PMID: 25174500. 15: Brabham C, Lei L, Gu Y, Stork J, Barrett M, DeBolt S. Indaziflam herbicidal action: a potent cellulose biosynthesis inhibitor. Plant Physiol. 2014 Nov;166(3):1177-85. doi: 10.1104/pp.114.241950. Epub 2014 Jul 30. PubMed PMID: 25077797; PubMed Central PMCID: PMC4226351. 16: Fenoll J, Garrido I, Hellín P, Flores P, Vela N, Navarro S. Use of different organic wastes in reducing the potential leaching of propanil, isoxaben, cadusafos and pencycuron through the soil. J Environ Sci Health B. 2014;49(8):601-8. doi: 10.1080/03601234.2014.911581. PubMed PMID: 24901963. 17: Sahoo DK, Maiti IB. Biomass derived from transgenic tobacco expressing the Arabidopsis CESA3ixr1-2 gene exhibits improved saccharification. Acta Biol Hung. 2014 Jun;65(2):189-204. doi: 10.1556/ABiol.65.2014.2.7. PubMed PMID: 24873912. 18: Steinwand BJ, Xu S, Polko JK, Doctor SM, Westafer M, Kieber JJ. Alterations in auxin homeostasis suppress defects in cell wall function. PLoS One. 2014 May 23;9(5):e98193. doi: 10.1371/journal.pone.0098193. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e110992. PubMed PMID: 24859261; PubMed Central PMCID: PMC4032291. 19: Panteris E, Adamakis ID, Daras G, Hatzopoulos P, Rigas S. Differential responsiveness of cortical microtubule orientation to suppression of cell expansion among the developmental zones of Arabidopsis thaliana root apex. PLoS One. 2013 Dec 4;8(12):e82442. doi: 10.1371/journal.pone.0082442. eCollection 2013. PubMed PMID: 24324790; PubMed Central PMCID: PMC3853581. 20: Toda Y, Yoshida M, Hattori T, Takeda S. RICE SALT SENSITIVE3 binding to bHLH and JAZ factors mediates control of cell wall plasticity in the root apex. Plant Signal Behav. 2013 Nov;8(11):e26256. doi: 10.4161/psb.26256. Epub 2013 Aug 29. PubMed PMID: 23989667; PubMed Central PMCID: PMC4091359.

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