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MedKoo Cat#: 330130 | Name: Alpha-Chloralose
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alpha-Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.

Chemical Structure

Alpha-Chloralose
CAS#15879-93-3

Theoretical Analysis

MedKoo Cat#: 330130

Name: Alpha-Chloralose

CAS#: 15879-93-3

Chemical Formula: C8H11Cl3O6

Exact Mass: 307.9621

Molecular Weight: 309.52

Elemental Analysis: C, 31.04; H, 3.58; Cl, 34.36; O, 31.01

Price and Availability

Size Price Availability Quantity
25g USD 350.00 2 Weeks
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Related CAS #
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Synonym
Alpha-Chloralose; Anhydro-D-glucochloral; Chloralose
IUPAC/Chemical Name
(1R)-1-((3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol
InChi Key
OJYGBLRPYBAHRT-ZMKYHYQQSA-N
InChi Code
InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7?/m1/s1
SMILES Code
O[C@@H]([C@@H]([C@@H](CO)O)O1)[C@@H](O2)[C@H]1OC2C(Cl)(Cl)Cl
Appearance
Solid powder
Purity
>80% (contains ≤20% β-isomer)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shen B, Wang J, Tai C, Beckel JM. Facilitation of non-nociceptive bladder activity and suppression of somatic afferent inhibition by hypogastric afferents in cats. Front Neurosci. 2025 Feb 20;19:1555152. doi: 10.3389/fnins.2025.1555152. PMID: 40052090; PMCID: PMC11882540. 2: Yuan Y, Liu T, Wang J. Enhancing anesthetic techniques for improving whisker stimulation response in the barrel cortex. PLoS One. 2025 Feb 25;20(2):e0318306. doi: 10.1371/journal.pone.0318306. PMID: 39999042. 3: Yuan Y, Li S, Wu L, Wang J. The efficient method to get better raw brain signal on rat anesthetics experiment. J Pharmacol Toxicol Methods. 2024 Sep- Oct;129:107551. doi: 10.1016/j.vascn.2024.107551. Epub 2024 Sep 7. PMID: 39245416. 4: Owens MM, Jacquemet V, Napadow V, Lewis N, Beaumont E. Brainstem neuronal responses to transcutaneous auricular and cervical vagus nerve stimulation in rats. J Physiol. 2024 Aug;602(16):4027-4052. doi: 10.1113/JP286680. Epub 2024 Jul 19. PMID: 39031516; PMCID: PMC11326965. 5: Lundgren S, Dreimanis K, Engdahl K, Windahl U, Tegner C. Alpha-chloralose poisoning in 25 cats: clinical picture and evaluation of treatment with intravenous lipid emulsion. J Feline Med Surg. 2024 Apr;26(4):1098612X241235776. doi: 10.1177/1098612X241235776. PMID: 38687210; PMCID: PMC11103310. 6: Peng SL, Huang SM, Chu LWL, Chiu SC. Anesthetic modulation of water diffusion: Insights from a diffusion tensor imaging study. Med Eng Phys. 2023 Aug;118:104015. doi: 10.1016/j.medengphy.2023.104015. Epub 2023 Jun 25. PMID: 37536836. 7: Pintauro M, Jian J, Wang J, Shen B, Scolieri J, Madhavaram A, Chermansky C, Beckel J, de Groat WC, Tai C. Role of opioid and β-adrenergic receptors in bladder underactivity induced by prolonged pudendal nerve stimulation in cats. Neurourol Urodyn. 2023 Aug;42(6):1344-1351. doi: 10.1002/nau.25226. Epub 2023 Jun 12. PMID: 37306331; PMCID: PMC10460192. 8: Dijkman MA, Robben JH, van Riel AJHP, de Lange DW. Evidence of a sudden increase in α-chloralose poisoning in dogs and cats in the Netherlands between 2018 and 2021. Vet Rec. 2023 Jan;192(1):e2342. doi: 10.1002/vetr.2342. Epub 2022 Oct 31. PMID: 36314571. 9: Windahl U, Tevell Åberg A, Kryuchkov F, Lundgren S, Tegner C, Dreimanis K, Koivisto S, Simola O, Sandvik M, Bernhoft A. Alpha-chloralose poisoning in cats in three Nordic countries - the importance of secondary poisoning. BMC Vet Res. 2022 Sep 5;18(1):334. doi: 10.1186/s12917-022-03370-w. PMID: 36064401; PMCID: PMC9446805. 10: Bellusci L, Kim E, Garcia DuBar S, Gillis RA, Vicini S, Sahibzada N. Brainstem activation of GABAB receptors in the nucleus tractus solitarius increases gastric motility. Front Neurosci. 2022 Aug 2;16:961042. doi: 10.3389/fnins.2022.961042. PMID: 35983226; PMCID: PMC9379309. 11: Baek K, Park CR, Jang S, Shim WH, Kim YR. Anesthetic modulations dissociate neuroelectric characteristics between sensory-evoked and spontaneous activities across bilateral rat somatosensory cortical laminae. Sci Rep. 2022 Jul 8;12(1):11661. doi: 10.1038/s41598-022-13759-0. PMID: 35804171; PMCID: PMC9270342. 12: Tegner C, Lundgren S, Dreimanis K, Åberg AT, Windahl U. Alpha-chloralose poisoning in cats: clinical findings in 25 confirmed and 78 suspected cases. J Feline Med Surg. 2022 Oct;24(10):e324-e329. doi: 10.1177/1098612X221107787. Epub 2022 Jun 27. PMID: 35757929; PMCID: PMC9510939. 13: Mukhomedzyanov AV, Popov SV, Maslov LN. δ2-Opioid Receptors as a Target in Designing New Cardioprotective Drugs: the Role of Protein Kinase C, AMPK, and Sarcolemmal KATP Channels. Bull Exp Biol Med. 2022 May;173(1):33-36. doi: 10.1007/s10517-022-05487-2. Epub 2022 May 27. PMID: 35622247. 14: Naitou K, Iwashita H, Ueda HH, Shiraishi M, Fujimoto Y, Horii K, Sawamura T, Shiina T, Shimizu Y. Intrathecally administered substance P activated the spinal defecation center and enhanced colorectal motility in anesthetized rats. Am J Physiol Gastrointest Liver Physiol. 2022 Jul 1;323(1):G21-G30. doi: 10.1152/ajpgi.00342.2021. Epub 2022 Apr 26. PMID: 35470689. 15: Horii K, Sawamura T, Onishi A, Yuki N, Naitou K, Shiina T, Shimizu Y. Contribution of sex hormones to the sexually dimorphic response of colorectal motility to noxious stimuli in rats. Am J Physiol Gastrointest Liver Physiol. 2022 Jun 1;323(1):G1-G8. doi: 10.1152/ajpgi.00033.2022. Epub 2022 Apr 19. PMID: 35438007. 16: Shen B, Wang J, Shen Z, Jian J, Goosby K, Beckel J, de Groat WC, Tai C. Sacral neuromodulation of bladder underactivity induced by prolonged pudendal afferent firing in cats. Am J Physiol Regul Integr Comp Physiol. 2022 Jun 1;322(6):R535-R541. doi: 10.1152/ajpregu.00012.2022. Epub 2022 Mar 23. PMID: 35319898; PMCID: PMC9076414. 17: Martin D, Reihe C, Drummer S, Roessler K, Boomer S, Nelson M. Venoconstrictor responses to activation of bradykinin-sensitive pericardial afferents involve the region of the hypothalamic paraventricular nucleus. Physiol Rep. 2022 Mar;10(6):e15221. doi: 10.14814/phy2.15221. PMID: 35307973; PMCID: PMC8935126. 18: Arens A, Teske J, Klintschar M, Mischke R, Dziadosz M. Antemortem and postmortem rodenticide analysis in forensic toxicology as a part of an LC-MS/MS- based multi-target screening strategy. Drug Test Anal. 2022 Jun;14(6):1149-1154. doi: 10.1002/dta.3222. Epub 2022 Jan 17. PMID: 34997698. 19: Almeida RL, Ogihara CA, de Souza JS, Oliveira KC, Cafarchio EM, Tescaro L, Maciel RMB, Giannocco G, Sato MA. Regularly swimming exercise modifies opioidergic neuromodulation in rostral ventrolateral medulla in hypertensive rats. Brain Res. 2022 Jan 1;1774:147726. doi: 10.1016/j.brainres.2021.147726. Epub 2021 Nov 14. PMID: 34785257. 20: Thorsdottir D, Einwag Z, Erdos B. BDNF shifts excitatory-inhibitory balance in the paraventricular nucleus of the hypothalamus to elevate blood pressure. J Neurophysiol. 2021 Oct 1;126(4):1209-1220. doi: 10.1152/jn.00247.2021. Epub 2021 Aug 18. PMID: 34406887; PMCID: PMC8560414.