MedKoo Cat#: 555229 | Name: ACSS-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ACSS-1, also known as MDK-6149 and ACSS2 Inhibitor or Ac-CoA Synthase Inhibitor I, is a Ac-CoA Synthase Inhibitor. MDK-6149 has CAS#508186-14-9. It was first reported in 2014. Cell. 159, 1591. For the convenience of scientific communication, we temporally name it as MDK-6149. The last 4 digit of its CAS# was used for name.

Chemical Structure

ACSS-1
ACSS-1
CAS#508186-14-9

Theoretical Analysis

MedKoo Cat#: 555229

Name: ACSS-1

CAS#: 508186-14-9

Chemical Formula: C20H18N4O2S2

Exact Mass: 410.0871

Molecular Weight: 410.51

Elemental Analysis: C, 58.52; H, 4.42; N, 13.65; O, 7.79; S, 15.62

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,550.00 2 Weeks
500mg USD 2,650.00 2 weeks
1g USD 3,950.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Synonym
ACSS-1; Ac-CoA Synthase Inhibitor I; MDK-6149; MDK 6149; MDK6149; ACSS2 Inhibitor
IUPAC/Chemical Name
1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea
InChi Key
CTPVNWVUAGMHEJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H18N4O2S2/c1-26-9-8-21-20(25)22-13-6-7-14-15(12-13)24-19(17-5-3-11-28-17)18(23-14)16-4-2-10-27-16/h2-7,10-12H,8-9H2,1H3,(H2,21,22,25)
SMILES Code
O=C(NCCOC)NC1=CC=C2N=C(C3=CC=CS3)C(C4=CC=CS4)=NC2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
[1]. Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP. Acetate dependence of tumors. Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020. PMID: 25525877; PMCID: PMC4272450. [2]. Bill Severson, et al. Anti-viral treatment and assay to screen for anti-viral agent. WO 2011097607 A1 https://patents.google.com/patent/WO2011097607A1