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MedKoo Cat#: 527833 | Name: Amfonelic Acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amfonelic Acid is a blocker of dopamine uptake. Amfonelic acid attenuated the stimulatory effects of clozapine on DOPAC concentrations and DOPA accumulation in the striatum as well as in the nucleus accumbens. Amfonelic acid selectively prevented the methamphetamine-induced decrease in tyrosine hydroxylase activity while not altering the depression of tryptophan hydroxylase activity. In vitro, amfonelic acid blocked methamphetamine-induced [3H]dopamine release from neostriatal slices but had no effect on [3H]serotonin release.

Chemical Structure

Amfonelic Acid
Amfonelic Acid
CAS#15180-02-6

Theoretical Analysis

MedKoo Cat#: 527833

Name: Amfonelic Acid

CAS#: 15180-02-6

Chemical Formula: C18H16N2O3

Exact Mass: 308.1161

Molecular Weight: 308.34

Elemental Analysis: C, 70.12; H, 5.23; N, 9.09; O, 15.57

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Amfonelic Acid
IUPAC/Chemical Name
7-Benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
InChi Key
WHHHJDGNBVQNAU-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23)
SMILES Code
O=C(C1=CN(CC)C2=NC(CC3=CC=CC=C3)=CC=C2C1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 308.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cox ET, Jarrett TM, McMurray MS, Greenhill K, Hofler VE, Williams SK, Joyner PW, Middleton CL, Walker CH, Johns JM. Combined norepinephrine/serotonergic reuptake inhibition: effects on maternal behavior, aggression, and oxytocin in the rat. Front Psychiatry. 2011 Jun 8;2:34. doi: 10.3389/fpsyt.2011.00034. eCollection 2011. PubMed PMID: 21713063; PubMed Central PMCID: PMC3114092. 2: Bongiovanni R, Young D, Newbould E, Jaskiw GE. Increased striatal dopamine synthesis is associated with decreased tissue levels of tyrosine. Brain Res. 2006 Oct 18;1115(1):26-36. Epub 2006 Aug 24. PubMed PMID: 16934236. 3: Johns JM, Joyner PW, McMurray MS, Elliott DL, Hofler VE, Middleton CL, Knupp K, Greenhill KW, Lomas LM, Walker CH. The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat. Pharmacol Biochem Behav. 2005 Aug;81(4):769-85. PubMed PMID: 15996723; PubMed Central PMCID: PMC3110079. 4: Johns JM, Lubin DA, Walker CH, Joyner P, Middleton C, Hofler V, McMurray M. Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams. Int J Dev Neurosci. 2004 Aug-Oct;22(5-6):321-8. PubMed PMID: 15380831; PubMed Central PMCID: PMC3109071. 5: Patel J, Mooslehner KA, Chan PM, Emson PC, Stamford JA. Presynaptic control of striatal dopamine neurotransmission in adult vesicular monoamine transporter 2 (VMAT2) mutant mice. J Neurochem. 2003 May;85(4):898-910. PubMed PMID: 12716422. 6: Davids E, Zhang K, Kula NS, Tarazi FI, Baldessarini RJ. Effects of norepinephrine and serotonin transporter inhibitors on hyperactivity induced by neonatal 6-hydroxydopamine lesioning in rats. J Pharmacol Exp Ther. 2002 Jun;301(3):1097-102. PubMed PMID: 12023542. 7: Pothos EN. Regulation of dopamine quantal size in midbrain and hippocampal neurons. Behav Brain Res. 2002 Mar 10;130(1-2):203-7. PubMed PMID: 11864736. 8: Brown JM, Hanson GR, Fleckenstein AE. Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants. J Pharmacol Exp Ther. 2001 Mar;296(3):762-7. PubMed PMID: 11181904. 9: Wirtshafter D. A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats. Neurosci Lett. 2000 Aug 4;289(2):99-102. PubMed PMID: 10904129. 10: Tsuchiya K. [Effects of methamphetamine on responsiveness to conditioned fear stress]. Hokkaido Igaku Zasshi. 1999 Jan;74(1):41-52. Japanese. PubMed PMID: 10331059. 11: Baillien M, Balthazart J. A direct dopaminergic control of aromatase activity in the quail preoptic area. J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):99-113. PubMed PMID: 9449211. 12: Tirelli E, Geter-Douglass B, Witkin JM. gamma-Aminobutyric acidA agonists differentially augment gnawing induced by indirect-acting dopamine agonists in C57BL/6J mice. J Pharmacol Exp Ther. 1998 Jan;284(1):116-24. PubMed PMID: 9435169. 13: Pothos EN, Sulzer D. Modulation of quantal dopamine release by psychostimulants. Adv Pharmacol. 1998;42:198-202. PubMed PMID: 9327878. 14: Castagna C, Ball GF, Balthazart J. Effects of dopamine agonists on appetitive and consummatory male sexual behavior in Japanese quail. Pharmacol Biochem Behav. 1997 Oct;58(2):403-14. PubMed PMID: 9300599. 15: Huang NK, Wan FJ, Tseng CJ, Tung CS. Amphetamine induces hydroxyl radical formation in the striatum of rats. Life Sci. 1997;61(22):2219-29. PubMed PMID: 9393941. 16: Agmo A, Belzung C, Rodríguez C. A rat model of distractibility: effects of drugs modifying dopaminergic, noradrenergic and GABAergic neurotransmission. J Neural Transm (Vienna). 1997;104(1):11-29. PubMed PMID: 9085190. 17: Tsuchiya K, Inoue T, Koyama T. Effect of repeated methamphetamine pretreatment on freezing behavior induced by conditioned fear stress. Pharmacol Biochem Behav. 1996 Aug;54(4):687-91. PubMed PMID: 8853190. 18: Agmo A, Belzung C, Giordano M. Interactions between dopamine and GABA in the control of ambulatory activity. J Neural Transm (Vienna). 1996;103(8-9):925-34. PubMed PMID: 9013386. 19: Agmo A, Villalpando A. Central nervous stimulants facilitate sexual behavior in male rats with medial prefrontal cortex lesions. Brain Res. 1995 Oct 23;696(1-2):187-93. PubMed PMID: 8574668. 20: Nakachi N, Kiuchi Y, Inagaki M, Inazu M, Yamazaki Y, Oguchi K. Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats. Eur J Pharmacol. 1995 Aug 4;281(2):195-203. PubMed PMID: 7589207.