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MedKoo Cat#: 562458 | Name: CKI-7 2HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CKI-7 2HCl is a casein kinase 1 (CK1) inhibitor.

Chemical Structure

CKI-7 2HCl
CKI-7 2HCl
CAS#1177141-67-1

Theoretical Analysis

MedKoo Cat#: 562458

Name: CKI-7 2HCl

CAS#: 1177141-67-1

Chemical Formula: C11H14Cl3N3O2S

Exact Mass: 356.9872

Molecular Weight: 358.66

Elemental Analysis: C, 36.84; H, 3.93; Cl, 29.65; N, 11.72; O, 8.92; S, 8.94

Price and Availability

Size Price Availability Quantity
5mg USD 385.00 2 Weeks
10mg USD 650.00 2 Weeks
25mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
CKI-7 dihydrochloride; CKI 7 dihydrochloride; CKI7 dihydrochloride; CKI-7 2HCl; CKI 7 2HCl; CKI7 2HCl;
IUPAC/Chemical Name
N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
InChi Key
JUAVTXYOCISSSL-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H
SMILES Code
O=S(C1=CC=C(Cl)C2=C1C=NC=C2)(NCCN)=O.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 358.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bowman BM, Sebolt KA, Hoff BA, Boes JL, Daniels DL, Heist KA, Galbán CJ, Patel RM, Zhang J, Beer DG, Ross BD, Rehemtulla A, Galbán S. Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer. Sci Signal. 2015 Jan 27;8(361):ra9. doi: 10.1126/scisignal.2005607. Erratum in: Sci Signal. 2015 Mar 17;8(368):er3. PubMed PMID: 25628462; PubMed Central PMCID: PMC4416214. 2: Rachidi N, Taly JF, Durieu E, Leclercq O, Aulner N, Prina E, Pescher P, Notredame C, Meijer L, Späth GF. Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection. Antimicrob Agents Chemother. 2014;58(3):1501-15. doi: 10.1128/AAC.02022-13. Epub 2013 Dec 23. PubMed PMID: 24366737; PubMed Central PMCID: PMC3957854. 3: Tian Y, Yue X, Luo D, Wazir R, Wang J, Wu T, Chen L, Liao B, Wang K. Increased proliferation of human bladder smooth muscle cells is mediated by physiological cyclic stretch via the PI3K SGK1 Kv1.3 pathway. Mol Med Rep. 2013 Jul;8(1):294-8. doi: 10.3892/mmr.2013.1473. Epub 2013 May 13. PubMed PMID: 23669863. 4: Boesger J, Wagner V, Weisheit W, Mittag M. Application of phosphoproteomics to find targets of casein kinase 1 in the flagellum of chlamydomonas. Int J Plant Genomics. 2012;2012:581460. doi: 10.1155/2012/581460. Epub 2012 Dec 18. PubMed PMID: 23316220; PubMed Central PMCID: PMC3536430. 5: Fong DH, Xiong B, Hwang J, Berghuis AM. Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. PLoS One. 2011 May 9;6(5):e19589. doi: 10.1371/journal.pone.0019589. PubMed PMID: 21573013; PubMed Central PMCID: PMC3090406. 6: Nyati S, Ranga R, Ross BD, Rehemtulla A, Bhojani MS. Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases. Anal Biochem. 2010 Oct 15;405(2):246-54. doi: 10.1016/j.ab.2010.06.020. Epub 2010 Jun 16. PubMed PMID: 20561505; PubMed Central PMCID: PMC2922438. 7: Gokhale A, Wirschell M, Sale WS. Regulation of dynein-driven microtubule sliding by the axonemal protein kinase CK1 in Chlamydomonas flagella. J Cell Biol. 2009 Sep 21;186(6):817-24. doi: 10.1083/jcb.200906168. Epub 2009 Sep 14. PubMed PMID: 19752022; PubMed Central PMCID: PMC2753152. 8: Osakada F, Jin ZB, Hirami Y, Ikeda H, Danjyo T, Watanabe K, Sasai Y, Takahashi M. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci. 2009 Sep 1;122(Pt 17):3169-79. doi: 10.1242/jcs.050393. Epub 2009 Aug 11. PubMed PMID: 19671662. 9: Agostino PV, Plano SA, Golombek DA. Circadian and pharmacological regulation of casein kinase I in the hamster suprachiasmatic nucleus. J Genet. 2008 Dec;87(5):467-71. PubMed PMID: 19147935. 10: Grozav AG, Chikamori K, Kozuki T, Grabowski DR, Bukowski RM, Willard B, Kinter M, Andersen AH, Ganapathi R, Ganapathi MK. Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity. Nucleic Acids Res. 2009 Feb;37(2):382-92. doi: 10.1093/nar/gkn934. Epub 2008 Nov 29. PubMed PMID: 19043076; PubMed Central PMCID: PMC2632902. 11: Alappat EC, Feig C, Boyerinas B, Volkland J, Samuels M, Murmann AE, Thorburn A, Kidd VJ, Slaughter CA, Osborn SL, Winoto A, Tang WJ, Peter ME. Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell. 2005 Aug 5;19(3):321-32. PubMed PMID: 16061179. 12: Izeradjene K, Douglas L, Delaney AB, Houghton JA. Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex. Cancer Res. 2004 Nov 1;64(21):8036-44. PubMed PMID: 15520213. 13: Fong DH, Berghuis AM. Crystallization and preliminary crystallographic analysis of 3'-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7. Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1897-9. Epub 2004 Sep 23. PubMed PMID: 15388945. 14: Miyazaki K, Nagase T, Mesaki M, Narukawa J, Ohara O, Ishida N. Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts. Biochem J. 2004 May 15;380(Pt 1):95-103. PubMed PMID: 14750904; PubMed Central PMCID: PMC1224138. 15: Rena G, Bain J, Elliott M, Cohen P. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 Jan;5(1):60-5. PubMed PMID: 14710188; PubMed Central PMCID: PMC1298959. 16: Calabokis M, Kurz L, Gonzatti MI, Bubis J. Protein kinase CK1 from Trypanosoma cruzi. J Protein Chem. 2003 Aug;22(6):591-9. PubMed PMID: 14703993. 17: Preuss F, Fan JY, Kalive M, Bao S, Schuenemann E, Bjes ES, Price JL. Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I. Mol Cell Biol. 2004 Jan;24(2):886-98. PubMed PMID: 14701759; PubMed Central PMCID: PMC343813. 18: Liu W, Xu ZH, Luo D, Xue HW. Roles of OsCKI1, a rice casein kinase I, in root development and plant hormone sensitivity. Plant J. 2003 Oct;36(2):189-202. PubMed PMID: 14535884. 19: Cooper CD, Lampe PD. Casein kinase 1 regulates connexin-43 gap junction assembly. J Biol Chem. 2002 Nov 22;277(47):44962-8. Epub 2002 Sep 20. PubMed PMID: 12270943. 20: Burzio V, Antonelli M, Allende CC, Allende JE. Biochemical and cellular characteristics of the four splice variants of protein kinase CK1alpha from zebrafish (Danio rerio). J Cell Biochem. 2002;86(4):805-14. PubMed PMID: 12210746.

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CL 43356

CL 43356