MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 562441 | Name: Chicago Sky Blue 6B
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chicago Sky Blue 6B is the first small molecule PrP ligand capable of inhibiting Aβ binding.

Chemical Structure

Chicago Sky Blue 6B
Chicago Sky Blue 6B
CAS#2610-05-1

Theoretical Analysis

MedKoo Cat#: 562441

Name: Chicago Sky Blue 6B

CAS#: 2610-05-1

Chemical Formula: C34H24N6Na4O16S4

Exact Mass: 991.9722

Molecular Weight: 992.79

Elemental Analysis: C, 41.13; H, 2.44; N, 8.47; Na, 9.26; O, 25.78; S, 12.92

Price and Availability

Size Price Availability Quantity
25g USD 350.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Chicago Sky Blue 6B; Direct Blue 1; Chicago Sky Blue; Chicago Blue 6B; Chicago Skye Blue 6B; C.I. 24410; CSB6B; NCI 9617; Pontamine Sky Blue
IUPAC/Chemical Name
sodium 6,6'-((1E,1'E)-(3,3'-dimethoxy-[1,1'-biphenyl]-4,4'-diyl)bis(diazene-2,1-diyl))bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
InChi Key
BPHHNXJPFPEJOF-GPTZEZBUSA-J
InChi Code
InChI=1S/C34H28N6O16S4.4Na/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-37+,40-38+;;;;
SMILES Code
O=S(C1=C2C=CC(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(O)C6=C(N)C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6C=C5)C(OC)=C4)C=C3OC)=C(O)C2=C(N)C(S(=O)([O-])=O)=C1)([O-])=O.[Na+].[Na+].[Na+].[Na+]
Appearance
Solid powder
Purity
>90% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 992.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Donkers JM, Zehnder B, van Westen GJP, Kwakkenbos MJ, IJzerman AP, Oude Elferink RPJ, Beuers U, Urban S, van de Graaf SFJ. Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP. Sci Rep. 2017 Nov 10;7(1):15307. doi: 10.1038/s41598-017-15338-0. PubMed PMID: 29127322; PubMed Central PMCID: PMC5681660. 2: Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H. YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma. Pharmacol Res. 2017 Jun;120:242-251. doi: 10.1016/j.phrs.2017.04.006. Epub 2017 Apr 8. PubMed PMID: 28396094. 3: Nguyen T, Ho M, Ghosh A, Kim T, Yun SI, Lee SS, Kim KK. An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors. Biochem Biophys Res Commun. 2016 Oct 7;479(1):33-9. doi: 10.1016/j.bbrc.2016.09.010. Epub 2016 Sep 7. PubMed PMID: 27613091. 4: Prakash R, Prashanth HV, Ragunatha S, Kapoor M, Anitha TK, Krishnamurthy V. Comparative study of efficacy, rapidity of detection, and cost-effectiveness of potassium hydroxide, calcofluor white, and Chicago sky blue stains in the diagnosis of dermatophytoses. Int J Dermatol. 2016 Apr;55(4):e172-5. doi: 10.1111/ijd.13037. Epub 2016 Feb 9. PubMed PMID: 26861859. 5: Wang ZT, Yu G, Wang HS, Yi SP, Su RB, Gong ZH. Changes in VGLUT2 expression and function in pain-related supraspinal regions correlate with the pathogenesis of neuropathic pain in a mouse spared nerve injury model. Brain Res. 2015 Oct 22;1624:515-524. doi: 10.1016/j.brainres.2015.08.010. Epub 2015 Aug 20. PubMed PMID: 26300222. 6: Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015 Jul-Aug;60(4):340-4. doi: 10.4103/0019-5154.160476. PubMed PMID: 26288400; PubMed Central PMCID: PMC4533529. 7: Risse E, Nicoll AJ, Taylor WA, Wright D, Badoni M, Yang X, Farrow MA, Collinge J. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015 Jul 3;290(27):17020-8. doi: 10.1074/jbc.M115.637124. Epub 2015 May 20. PubMed PMID: 25995455; PubMed Central PMCID: PMC4505445. 8: Roy M, Ghosh S, Naskar MK. Ligand-assisted soft-chemical synthesis of self-assembled different shaped mesoporous Co3O4: efficient visible light photocatalysts. Phys Chem Chem Phys. 2015 Apr 21;17(15):10160-9. doi: 10.1039/c5cp00649j. PubMed PMID: 25792483. 9: Liu Z, Sheng P, Yang YP, Li W, Huang WM, Wang JD, Fan YM. Comparison of modified Chicago sky blue stain and potassium hydroxide mount for the diagnosis of dermatomycoses and onychomycoses. J Microbiol Methods. 2015 May;112:21-3. doi: 10.1016/j.mimet.2015.02.013. Epub 2015 Mar 9. PubMed PMID: 25765148. 10: Saxena T, Loomis KH, Pai SB, Karumbaiah L, Gaupp E, Patil K, Patkar R, Bellamkonda RV. Nanocarrier-mediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury. ACS Nano. 2015 Feb 24;9(2):1492-505. doi: 10.1021/nn505980z. Epub 2015 Jan 28. PubMed PMID: 25587936. 11: Normand A, Rivière E, Renodon-Cornière A. Identification and characterization of human Rad51 inhibitors by screening of an existing drug library. Biochem Pharmacol. 2014 Oct 1;91(3):293-300. doi: 10.1016/j.bcp.2014.07.033. Epub 2014 Aug 11. PubMed PMID: 25124703. 12: Roy M, Ghosh S, Naskar MK. Synthesis of morphology controllable porous Co3O4 nanostructures with tunable textural properties and their catalytic application. Dalton Trans. 2014 Jul 14;43(26):10248-57. doi: 10.1039/c4dt00608a. Epub 2014 May 30. PubMed PMID: 24878520. 13: He Z, Chen Y, Dong H, Su R, Gong Z, Yan L. Inhibition of vesicular glutamate transporters contributes to attenuate methamphetamine-induced conditioned place preference in rats. Behav Brain Res. 2014 Jul 1;267:1-5. doi: 10.1016/j.bbr.2014.02.047. Epub 2014 Mar 6. PubMed PMID: 24613241. 14: Giansanti F, Schiavone N, Papucci L, Bitossi A, Andreucci E, Pontenani F, Cutrì M, Menchini U. Safety testing of blue vital dyes using cell culture models. J Ocul Pharmacol Ther. 2014 Jun;30(5):406-12. doi: 10.1089/jop.2013.0213. Epub 2014 Feb 7. PubMed PMID: 24506324. 15: Theron KE, Penny CB, Hosie MJ. The Bax/Bcl-2 apoptotic pathway is not responsible for the increase in apoptosis in the RU486-treated rat uterus during early pregnancy. Reprod Biol. 2013 Dec;13(4):290-7. doi: 10.1016/j.repbio.2013.09.002. Epub 2013 Oct 4. PubMed PMID: 24287037. 16: Yu G, Yi S, Wang M, Yan H, Yan L, Su R, Gong Z. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013 Dec;24(8):653-8. doi: 10.1097/FBP.0000000000000007. PubMed PMID: 24128751. 17: Arun Prasad AS, Satyanarayana VS, Bhaskara Rao KV. Biotransformation of Direct Blue 1 by a moderately halophilic bacterium Marinobacter sp. strain HBRA and toxicity assessment of degraded metabolites. J Hazard Mater. 2013 Nov 15;262:674-84. doi: 10.1016/j.jhazmat.2013.09.011. Epub 2013 Sep 16. PubMed PMID: 24121630. 18: Neale SA, Copeland CS, Salt TE. Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex. Neurochem Int. 2014 Jul;73:159-65. doi: 10.1016/j.neuint.2013.10.001. Epub 2013 Oct 10. PubMed PMID: 24121008. 19: Mohamed RM, Mkhalid IA, Al-Thabaiti SA, Mokhtar M. Nano Cu metal doped on TiO2-SiO2 nanoparticle catalysts in photocatalytic degradation of direct blue dye. J Nanosci Nanotechnol. 2013 Jul;13(7):4975-80. PubMed PMID: 23901519. 20: He Z, Yan L, Yong Z, Dong Z, Dong H, Gong Z. Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice. Behav Brain Res. 2013 Feb 15;239:172-6. doi: 10.1016/j.bbr.2012.11.003. Epub 2012 Nov 14. PubMed PMID: 23159705.