MedKoo Cat#: 562440 | Name: STS-E412

Description:

WARNING: This product is for research use only, not for human or veterinary use.

STS-E412 is the first nonpeptidyl, selective activator of the tissue-protective EPOR/CD131 receptor.

Chemical Structure

STS-E412
STS-E412
CAS#1609980-39-3

Theoretical Analysis

MedKoo Cat#: 562440

Name: STS-E412

CAS#: 1609980-39-3

Chemical Formula: C15H15ClN4O2

Exact Mass: 318.0884

Molecular Weight: 318.76

Elemental Analysis: C, 56.52; H, 4.74; Cl, 11.12; N, 17.58; O, 10.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
STS-E412; STS E412; STSE412;
IUPAC/Chemical Name
2-[2-(4-Chlorophenoxy)ethoxy]-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine
InChi Key
XQFMOBKQELKMKF-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H15ClN4O2/c1-10-9-11(2)20-14(17-10)18-15(19-20)22-8-7-21-13-5-3-12(16)4-6-13/h3-6,9H,7-8H2,1-2H3
SMILES Code
CC1=CC(C)=NC2=NC(OCCOC3=CC=C(Cl)C=C3)=NN12
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 318.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Miller JL, Rai M, Frigon NL, Pandolfo M, Punnonen J, Spencer JR. Erythropoietin and small molecule agonists of the tissue-protective erythropoietin receptor increase FXN expression in neuronal cells in vitro and in Fxn-deficient KIKO mice in vivo. Neuropharmacology. 2017 Sep 1;123:34-45. doi: 10.1016/j.neuropharm.2017.05.011. Epub 2017 May 11. PubMed PMID: 28504123. 2: Miller JL, Church TJ, Leonoudakis D, Lariosa-Willingham K, Frigon NL, Tettenborn CS, Spencer JR, Punnonen J. Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor. Mol Pharmacol. 2015 Aug;88(2):357-67. doi: 10.1124/mol.115.098400. Epub 2015 May 27. PubMed PMID: 26018904; PubMed Central PMCID: PMC4518087.