MedKoo Cat#: 562437 | Name: FICZ

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FICZ is a potent aryl hydrogen receptor (AhR) agonist (Kd = 70 p M). It acts by inducing transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Chemical Structure

FICZ
FICZ
CAS#172922-91-7

Theoretical Analysis

MedKoo Cat#: 562437

Name: FICZ

CAS#: 172922-91-7

Chemical Formula: C19H10N2O

Exact Mass: 282.0793

Molecular Weight: 282.30

Elemental Analysis: C, 80.84; H, 3.57; N, 9.92; O, 5.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
FICZ; 6-Formylindolo[3,2-b]carbazole;
IUPAC/Chemical Name
indolo[3,2-b]carbazole-6-carbaldehyde
InChi Key
OTWFDHQTFRXSAK-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H10N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10H
SMILES Code
O=CC(C1=NC2=CC=CC=C2C1=C3)=C4C3=NC5=CC=CC=C54
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 282.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bock KW. Human and rodent aryl hydrocarbon receptor (AHR): from mediator of dioxin toxicity to physiologic AHR functions and therapeutic options. Biol Chem. 2017 Apr 1;398(4):455-464. doi: 10.1515/hsz-2016-0303. Review. PubMed PMID: 27805907. 2: Bock KW. From dioxin toxicity to putative physiologic functions of the human Ah receptor in homeostasis of stem/progenitor cells. Biochem Pharmacol. 2017 Jan 1;123:1-7. doi: 10.1016/j.bcp.2016.06.015. Epub 2016 Jun 25. Review. PubMed PMID: 27349986. 3: Bock KW. Toward elucidation of dioxin-mediated chloracne and Ah receptor functions. Biochem Pharmacol. 2016 Jul 15;112:1-5. doi: 10.1016/j.bcp.2016.01.010. Epub 2016 Jan 23. Review. PubMed PMID: 26801687. 4: Ficz G. New insights into mechanisms that regulate DNA methylation patterning. J Exp Biol. 2015 Jan 1;218(Pt 1):14-20. doi: 10.1242/jeb.107961. Review. PubMed PMID: 25568447. 5: Ficz G, Gribben JG. Loss of 5-hydroxymethylcytosine in cancer: cause or consequence? Genomics. 2014 Nov;104(5):352-7. doi: 10.1016/j.ygeno.2014.08.017. Epub 2014 Aug 30. Review. PubMed PMID: 25179374; PubMed Central PMCID: PMC4566966. 6: Bock KW. Homeostatic control of xeno- and endobiotics in the drug-metabolizing enzyme system. Biochem Pharmacol. 2014 Jul 1;90(1):1-6. doi: 10.1016/j.bcp.2014.04.009. Epub 2014 May 16. Review. PubMed PMID: 24837423. 7: Sibilano R, Pucillo CE, Gri G. Allergic responses and aryl hydrocarbon receptor novel pathway of mast cell activation. Mol Immunol. 2015 Jan;63(1):69-73. doi: 10.1016/j.molimm.2014.02.015. Epub 2014 Mar 18. Review. PubMed PMID: 24656327. 8: Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2011 Nov 15;13(1):7-13. doi: 10.1038/nrg3080. Review. PubMed PMID: 22083101. 9: Ma Q. Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease. Expert Opin Drug Metab Toxicol. 2011 Oct;7(10):1267-93. doi: 10.1517/17425255.2011.614947. Epub 2011 Sep 2. Review. PubMed PMID: 21883026. 10: Heintzmann R, Ficz G. Breaking the resolution limit in light microscopy. Methods Cell Biol. 2007;81:561-80. Review. PubMed PMID: 17519184. 11: Heintzmann R, Ficz G. Breaking the resolution limit in light microscopy. Brief Funct Genomic Proteomic. 2006 Dec;5(4):289-301. Review. PubMed PMID: 17170013.