MedKoo Cat#: 562431 | Name: CM026

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CM026 is a selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor. It acts by binding within the aldehyde binding pocket of ALDH1A1 in an uncompetitive partial mode of inhibition.

Chemical Structure

CM026
CM026
CAS#851941-94-1

Theoretical Analysis

MedKoo Cat#: 562431

Name: CM026

CAS#: 851941-94-1

Chemical Formula: C22H30N6O4

Exact Mass: 442.2329

Molecular Weight: 442.52

Elemental Analysis: C, 59.71; H, 6.83; N, 18.99; O, 14.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
CM026; CM-026; CM 026;
IUPAC/Chemical Name
8-[[4-(3-Furoyl)-1-piperazinyl]methyl]-1,3-dimethyl-7-(3-methylbutyl)-3,7-dihydro-1H-purine-2,6-dione
InChi Key
DJKUMTHWYKAUNI-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H30N6O4/c1-15(2)5-7-28-17(23-19-18(28)21(30)25(4)22(31)24(19)3)13-26-8-10-27(11-9-26)20(29)16-6-12-32-14-16/h6,12,14-15H,5,7-11,13H2,1-4H3
SMILES Code
O=C(N1C)N(C)C2=C(N(CCC(C)C)C(CN3CCN(C(C4=COC=C4)=O)CC3)=N2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 442.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Morgan CA, Hurley TD. Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J Med Chem. 2015 Feb 26;58(4):1964-75. doi: 10.1021/jm501900s. Epub 2015 Feb 10. PubMed PMID: 25634381; PubMed Central PMCID: PMC4344389.