MedKoo Cat#: 562428 | Name: ZINC05626394
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZINC05626394 is a Cytochrome b5 reductase 3 (CYB5R3) inhibitor. It acts by increasing NO bioavailability.

Chemical Structure

ZINC05626394
ZINC05626394
CAS#189057-68-9

Theoretical Analysis

MedKoo Cat#: 562428

Name: ZINC05626394

CAS#: 189057-68-9

Chemical Formula: C11H10N2OS2

Exact Mass: 250.0200

Molecular Weight: 250.33

Elemental Analysis: C, 52.78; H, 4.03; N, 11.19; O, 6.39; S, 25.61

Price and Availability

Size Price Availability Quantity
5mg USD 230.00
25mg USD 580.00
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Related CAS #
No Data
Synonym
ZINC05626394; ZINC-05626394; ZINC 05626394;
IUPAC/Chemical Name
6-((phenylthio)methyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
InChi Key
VNTBGGWDZYETPH-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H10N2OS2/c14-10-6-8(12-11(15)13-10)7-16-9-4-2-1-3-5-9/h1-6H,7H2,(H2,12,13,14,15)
SMILES Code
O=C(C=C(CSC1=CC=CC=C1)N2)NC2=S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 250.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability. J Biol Chem. 2015 Jul 3;290(27):16861-72. doi: 10.1074/jbc.M114.629964. Epub 2015 May 22. PMID: 26001785; PMCID: PMC4505432.