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MedKoo Cat#: 581169 | Name: Piperidolate hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piperidolate hydrochloride is an antimuscarinic, Also a potential inhibitor of human glutathione transferase P1-1. Piperidolate HCl could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).

Chemical Structure

Piperidolate hydrochloride
Piperidolate hydrochloride
CAS#129-77-1

Theoretical Analysis

MedKoo Cat#: 581169

Name: Piperidolate hydrochloride

CAS#: 129-77-1

Chemical Formula: C21H26ClNO2

Exact Mass: 359.1652

Molecular Weight: 359.89

Elemental Analysis: C, 70.08; H, 7.28; Cl, 9.85; N, 3.89; O, 8.89

Price and Availability

Size Price Availability Quantity
2.5mg USD 280.00
100mg USD 450.00
2g USD 1,950.00
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Related CAS #
No Data
Synonym
Piperidolate hydrochloride; Dactil; Crapinon; NSC 4349; Piperidolate HCl;
IUPAC/Chemical Name
1-Ethyl-3-piperidyl diphenylacetate hydrochloride
InChi Key
RBGWCEWDAHDPEH-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25NO2.ClH/c1-2-22-15-9-14-19(16-22)24-21(23)20(17-10-5-3-6-11-17)18-12-7-4-8-13-18;/h3-8,10-13,19-20H,2,9,14-16H2,1H3;1H
SMILES Code
O=C(OC1CN(CC)CCC1)C(C2=CC=CC=C2)C3=CC=CC=C3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Piperidolate hydrochloride is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs).
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 32.0 88.92
Water 50.0 138.93
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 359.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Attwood D. Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives. J Pharm Pharmacol. 1976 May;28(5):407-9. PubMed PMID: 6747. 2: Kelkar MS. Atropine substitutes and the writhing syndrome in mice. Arch Int Pharmacodyn Ther. 1977 Sep;229(1):133-7. PubMed PMID: 931459. 3: FILIPAZZI A, LOSAPIO M. [Considerations on ventricular fibrillation in hypothermia and on the anti-fibrillating action of piperidolate hydrochloride]. Riv Patol Clin. 1961 Dec;16:926-30. Italian. PubMed PMID: 13892861. 4: HARA M, HARBERG FJ, HUDSON LH. Antifibrillatory action of piperidolate hydrochloride (dactil) in hypothermia. AMA Arch Surg. 1957 Nov;75(5):780-4. PubMed PMID: 13468923. 5: PIPERIDOLATE hydrochloride. J Am Med Assoc. 1957 May 18;164(3):281. PubMed PMID: 13415981. 6: SALLE J. [Effect of piperidolate hydrochloride on Oddi's sphincter function in the guinea pig]. C R Seances Soc Biol Fil. 1958;152(4):575-8. French. PubMed PMID: 13597345.