MedKoo Cat#: 341203 | Name: Tyrphostin AG 1112
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tyrphostin AG 1112 is a Bcr-Abl kinase blocker that can activate the terminal differentiation of K562 cells and the purging of Ph+ cells.

Chemical Structure

Tyrphostin AG 1112
Tyrphostin AG 1112
CAS#153150-84-6

Theoretical Analysis

MedKoo Cat#: 341203

Name: Tyrphostin AG 1112

CAS#: 153150-84-6

Chemical Formula: C15H10N6

Exact Mass: 274.0967

Molecular Weight: 274.29

Elemental Analysis: C, 65.68; H, 3.67; N, 30.64

Price and Availability

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1mg USD 285.00
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Synonym
Tyrphostin AG 1112; Tyrphostin AG-1112; Tyrphostin AG1112.
IUPAC/Chemical Name
1H-Pyrazole-3-acetonitrile, 5-amino-4-cyano-alpha-(1H-indol-3-ylmethylene), (Z)-
InChi Key
UATHROQEHSKMCY-KPBXGNTFSA-N
InChi Code
InChI=1S/C15H10N6/c16-6-9(14-12(7-17)15(18)21-20-14)5-10-8-19-13-4-2-1-3-11(10)13/h1-5,8,19,21H,18H2/b10-5+,14-9-
SMILES Code
c1cccc2c1[nH]cc2\C=C(/C#N)c1n[nH]c(c1C#N)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 274.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kang TB, Huang C, Liang NC. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8. PubMed PMID: 10072895. 2: Anafi M, Gazit A, Zehavi A, Ben-Neriah Y, Levitzki A. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9. PubMed PMID: 7505115.