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MedKoo Cat#: 555206 | Name: VUF-10214

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VUF-10214 is a H4 receptor-ligand. In vivo studies in the rat reveal that VUF-10214 has significant anti-inflammatory properties in the carrageenan-induced paw-edema model.

Chemical Structure

VUF-10214
VUF-10214
CAS#848837-33-2

Theoretical Analysis

MedKoo Cat#: 555206

Name: VUF-10214

CAS#: 848837-33-2

Chemical Formula: C13H14Cl2N4O

Exact Mass: 312.0545

Molecular Weight: 313.18

Elemental Analysis: C, 49.86; H, 4.51; Cl, 22.64; N, 17.89; O, 5.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
VUF-10214; VUF 10214; VUF10214.
IUPAC/Chemical Name
6,7-dichloro 3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one
InChi Key
MFJVHWQDKIEBCM-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H14Cl2N4O/c1-18-2-4-19(5-3-18)12-13(20)17-11-7-9(15)8(14)6-10(11)16-12/h6-7H,2-5H2,1H3,(H,17,20)
SMILES Code
O=C1NC2=C(C=C(Cl)C(Cl)=C2)N=C1N3CCN(C)CC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 313.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pozzoli C, Adami M, Smits RA, Coruzzi G. Effect of histamine H4 receptor ligands on cholinergic neurotransmission of the rat duodenum. Inflamm Res. 2009 Apr;58 Suppl 1:59-60. doi: 10.1007/s00011-009-2012-4. PubMed PMID: 19271139. 2: Smits RA, Lim HD, Hanzer A, Zuiderveld OP, Guaita E, Adami M, Coruzzi G, Leurs R, de Esch IJ. Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51(8):2457-67. doi: 10.1021/jm7014217. Epub 2008 Mar 22. PubMed PMID: 18357976.