Synonym
HDL376; HDL-376; HDL 376; SDZ HDL376; SDZ-HDL376; SDZHDL376; SDZ HDL 376;
IUPAC/Chemical Name
N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea
InChi Key
CVLONJGXRCEARL-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H17ClN2S/c1-8(2)7-14-12(16)15-11-6-10(13)5-4-9(11)3/h4-6,8H,7H2,1-3H3,(H2,14,15,16)
SMILES Code
S=C(NCC(C)C)NC1=CC(Cl)=CC=C1C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
256.79
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nieland TJ, Shaw JT, Jaipuri FA, Maliga Z, Duffner JL, Koehler AN, Krieger M. Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. J Lipid Res. 2007 Aug;48(8):1832-45. Epub 2007 May 28. PubMed PMID: 17533223.
2: Coppola GM, Damon RE, Eskesen JB, France DS, Paterniti JR Jr. Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorg Med Chem Lett. 2006 Jan 1;16(1):113-7. Epub 2005 Oct 10. PubMed PMID: 16216504.
3: Stevens GJ, Hitchcock K, Wang YK, Coppola GM, Versace RW, Chin JA, Shapiro M, Suwanrumpha S, Mangold BL. In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adduct. Chem Res Toxicol. 1997 Jul;10(7):733-41. PubMed PMID: 9250406.
