TY-52156 | CAS#934369-14-9 | S1P3 receptor antagonist

MedKoo Cat#: 562389 | Name: TY-52156

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TY-52156 is a S1P3 receptor antagonist. TY-52156 inhibited both the S1P-induced increase in [Ca(2+)](i) and Rho activation. In contrast, VPC23019 and JTE013 inhibited only the increase in [Ca(2+)](i) and Rho activation, respectively. TY-52156 inhibited FTY-720-induced S1P(3) receptor-mediated bradycardia in vivo. TY-52156 is both sensitive and useful as an S1P(3) receptor-specific antagonist and reveal that S1P induces vasoconstriction by directly activating S1P(3) receptor and through a subsequent increase in [Ca(2+)](i) and Rho activation in vascular smooth muscle cells.

Chemical Structure

TY-52156

CAS#934369-14-9

Theoretical Analysis

MedKoo Cat#: 562389

Name: TY-52156

CAS#: 934369-14-9

Chemical Formula: C18H19Cl2N3O

Exact Mass: 363.0905

Molecular Weight: 364.27

Elemental Analysis: C, 59.35; H, 5.26; Cl, 19.46; N, 11.54; O, 4.39

Price and Availability

Size	Price	Availability
25mg	USD 250.00	2 Weeks
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,450.00	2 Weeks
2g	USD 5,750.00	2 Weeks

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Related CAS #

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Synonym

TY-52156; TY 52156; TY52156;

IUPAC/Chemical Name

N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide

InChi Key

DBVLAHOFMRUWIC-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21)23(15-10-6-13(20)7-11-15)22-14-8-4-12(19)5-9-14/h4-11,21-22H,1-3H3

SMILES Code

CC(C)(C)C(C(N(C1=CC=C(Cl)C=C1)NC2=CC=C(Cl)C=C2)=N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 364.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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