MedKoo Cat#: 562383 | Name: CRANAD-28
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CRANAD-28 is a blood brain barrier (BBB) penetrable two-photon imaging probe. It acts by labelling plaques and cerebral amyloid angiopathies (CAAs).

Chemical Structure

CRANAD-28
CRANAD-28
CAS#1623747-97-6

Theoretical Analysis

MedKoo Cat#: 562383

Name: CRANAD-28

CAS#: 1623747-97-6

Chemical Formula: C27H25BF2N4O2

Exact Mass: 486.2039

Molecular Weight: 486.32

Elemental Analysis: C, 66.68; H, 5.18; B, 2.22; F, 7.81; N, 11.52; O, 6.58

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 3,850.00 2 Weeks
Show More
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
CRANAD-28; CRANAD 28; CRANAD28;
IUPAC/Chemical Name
(E)-4-(2-(2,2-difluoro-6-(2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)ethyl)-2H-1,3l3,2l4-dioxaborinin-4-yl)vinyl)-5-methyl-1-phenyl-1H-pyrazole
InChi Key
WXJHBEAKOQMUQO-FYWRMAATSA-N
InChi Code
InChI=1S/C27H25BF2N4O2/c1-20-22(18-31-33(20)24-9-5-3-6-10-24)13-15-26-17-27(36-28(29,30)35-26)16-14-23-19-32-34(21(23)2)25-11-7-4-8-12-25/h3-13,15,17-19H,14,16H2,1-2H3/b15-13+
SMILES Code
CC1=C(/C=C/C2=OB(F)(F)OC(CCC3=C(C)N(C4=CC=CC=C4)N=C3)=C2)C=NN1C5=CC=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 486.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang X, Tian Y, Yuan P, Li Y, Yaseen MA, Grutzendler J, Moore A, Ran C. A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease. Chem Commun (Camb). 2014 Oct 9;50(78):11550-3. doi: 10.1039/c4cc03731f. PubMed PMID: 25134928; PubMed Central PMCID: PMC4617557.