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MedKoo Cat#: 562372 | Name: Dyrk1B/1A-IN-9

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dyrk1B/1A-IN-9 is a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases.

Chemical Structure

Dyrk1B/1A-IN-9
Dyrk1B/1A-IN-9
CAS#1386979-55-0

Theoretical Analysis

MedKoo Cat#: 562372

Name: Dyrk1B/1A-IN-9

CAS#: 1386979-55-0

Chemical Formula: C23H17Cl2N5O4

Exact Mass: 497.0658

Molecular Weight: 498.32

Elemental Analysis: C, 55.44; H, 3.44; Cl, 14.23; N, 14.05; O, 12.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Dyrk1B/1A-IN-9; Dyrk1B inhibitor; 1A-IN-9; Dyrk-1B/1A-IN-9; Dyrk 1B/1A IN 9; Dyrk1B/1A-inhibitor-9;
IUPAC/Chemical Name
N-(2-Chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
InChi Key
CQKBSRPVZZLCJE-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H17Cl2N5O4/c1-34-23-27-11-14-8-16(22(33)29-19(14)30-23)21(32)28-18-9-13(5-6-17(18)25)20(31)26-10-12-3-2-4-15(24)7-12/h2-9,11H,10H2,1H3,(H,26,31)(H,28,32)(H,27,29,30,33)
SMILES Code
O=C(C1=CC2=CN=C(OC)N=C2NC1=O)NC3=CC(C(NCC4=CC=CC(Cl)=C4)=O)=CC=C3Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 498.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zou Y, Lim S, Lee K, Deng X, Friedman E. Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M. J Biol Chem. 2003 Dec 5;278(49):49573-81. Epub 2003 Sep 18. PubMed PMID: 14500717.