KHK-IN-8 | CAS#1303469-70-6 | KHK activity inbibitor

MedKoo Cat#: 562368 | Name: KHK-IN-8

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KHK-IN-8 is a reversible and ATP-competitive inhibitor of human hepatic KHK activity. It acts by efficiently blocking fructose-1-phosphate secretion.

Chemical Structure

KHK-IN-8

CAS#1303469-70-6

Theoretical Analysis

MedKoo Cat#: 562368

Name: KHK-IN-8

CAS#: 1303469-70-6

Chemical Formula: C21H26N8S

Exact Mass: 422.2001

Molecular Weight: 422.55

Elemental Analysis: C, 59.69; H, 6.20; N, 26.52; S, 7.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KHK-IN-8; KHK IN 8; KHKIN8; KHK inhibitor 8; KHK-inhibitor-8; Ketohexokinase Inhibitor 8;

IUPAC/Chemical Name

N8-(Cyclopropylmethyl)-N4-[2-(methylthio)phenyl]-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine

InChi Key

HFLMLZKGLUEWBU-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H26N8S/c1-30-16-5-3-2-4-15(16)26-20-17-18(19(25-13-24-17)23-12-14-6-7-14)27-21(28-20)29-10-8-22-9-11-29/h2-5,13-14,22H,6-12H2,1H3,(H,23,24,25)(H,26,27,28)

SMILES Code

CSC1=CC=CC=C1NC2=C(N=CN=C3NCC4CC4)C3=NC(N5CCNCC5)=N2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 422.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wu KL, Hung CY, Chan JY, Wu CW. An increase in adenosine-5'-triphosphate (ATP) content in rostral ventrolateral medulla is engaged in the high fructose diet-induced hypertension. J Biomed Sci. 2014 Jan 27;21:8. doi: 10.1186/1423-0127-21-8. PubMed PMID: 24467657; PubMed Central PMCID: PMC3913325.