MedKoo Cat#: 527815 | Name: Fenmetozole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenmetozole is an antagonist of the actions of ethanol.

Chemical Structure

Fenmetozole
Fenmetozole
CAS#41473-09-0

Theoretical Analysis

MedKoo Cat#: 527815

Name: Fenmetozole

CAS#: 41473-09-0

Chemical Formula: C10H10Cl2N2O

Exact Mass: 244.0170

Molecular Weight: 245.10

Elemental Analysis: C, 49.00; H, 4.11; Cl, 28.93; N, 11.43; O, 6.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Fenmetozole
IUPAC/Chemical Name
2-[(3,4-Dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole
InChi Key
FVHAONUKSUFJKN-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H10Cl2N2O/c11-8-2-1-7(5-9(8)12)15-6-10-13-3-4-14-10/h1-2,5H,3-4,6H2,(H,13,14)
SMILES Code
ClC1=CC=C(OCC2=NCCN2)C=C1Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 245.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Stillings MR, England CD, Welbourn AP, Smith CF. Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists. J Med Chem. 1986 Sep;29(9):1780-3. PubMed PMID: 2875186. 2: Chang H, Ewert SM, Nagel RL. Identification of 2-imidazolines as anti-sickling agents. Mol Pharmacol. 1983 May;23(3):731-4. PubMed PMID: 6865916. 3: Frye GD, Breese GR. An evaluation of the locomotor stimulating action of ethanol in rats and mice. Psychopharmacology (Berl). 1981;75(4):372-9. PubMed PMID: 6803283. 4: Vogel RA, Frye GD, Koepke KM, Mailman RB, Mueller RA, Breese GR. Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex. Alcohol Clin Exp Res. 1981 Summer;5(3):386-92. PubMed PMID: 6792942. 5: Frye GD, Breese GR, Mailman RB, Vogel RA, Ondrusek MG, Mueller RA. An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function. Psychopharmacology (Berl). 1980;69(2):149-55. PubMed PMID: 6256788. 6: Griffis LC, Bright TP, Cerimele BJ, Forney RB. Combined effects of fenmetozole and ethanol. Clin Pharmacol Ther. 1978 Sep;24(3):350-3. PubMed PMID: 357069. 7: Fink M, Irwin P. Fenmetazole (DH-524): euphoriant classified by cerebral electrometry. Curr Ther Res Clin Exp. 1975 Oct;18(4):590-6. PubMed PMID: 810320. 8: McNamee HB, Mendelson JH, Korn J. Fenmetozole in acute alcholol intoxication in man. Clin Pharmacol Ther. 1975 Jun;17(6):735-7. PubMed PMID: 1095283.