BPTQ | CAS#1802665-43-5 | DNA intercalator

MedKoo Cat#: 562342 | Name: BPTQ

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BPTQ is a typical intercalator of DNA. It acts by inducing dose-dependent inhibitory effect on the proliferation of cancer cells by arresting cells at S and G2/M phase and activating the mitochondria-mediated apoptosis pathway.

Chemical Structure

BPTQ

CAS#1802665-43-5

Theoretical Analysis

MedKoo Cat#: 562342

Name: BPTQ

CAS#: 1802665-43-5

Chemical Formula: C17H16N4S

Exact Mass: 308.1096

Molecular Weight: 308.40

Elemental Analysis: C, 66.21; H, 5.23; N, 18.17; S, 10.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

BPTQ; B-P-T-Q;

IUPAC/Chemical Name

4-Butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline

InChi Key

HNUWBMCYWQHNIN-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H16N4S/c1-2-3-8-18-16-15-14(19-10-20-16)12-9-11-6-4-5-7-13(11)21-17(12)22-15/h4-7,9-10H,2-3,8H2,1H3,(H,18,19,20)

SMILES Code

CCCCNC1=C2C(C3=CC4=CC=CC=C4N=C3S2)=NC=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 308.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rohit Kumar H, Kumar CS, Kiran Kumar HN, Advi Rao GM. Inhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline. Acta Pharm Sin B. 2017 May;7(3):303-310. doi: 10.1016/j.apsb.2017.01.001. Epub 2017 Mar 7. PubMed PMID: 28540166; PubMed Central PMCID: PMC5430831. 2: RohitKumar HG, Asha KR, Raghavan SC, Advi Rao GM. DNA intercalative 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline induces cell cycle arrest and apoptosis in leukemia cells. Cancer Chemother Pharmacol. 2015 Jun;75(6):1121-33. doi: 10.1007/s00280-015-2735-6. Epub 2015 Mar 29. PubMed PMID: 25819915.