MedKoo Cat#: 527798 | Name: Glaziovine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glaziovine is an anti-ulcerogenic natural alkaloid.

Chemical Structure

Glaziovine
Glaziovine
CAS#17127-48-9

Theoretical Analysis

MedKoo Cat#: 527798

Name: Glaziovine

CAS#: 17127-48-9

Chemical Formula: C18H19NO3

Exact Mass: 297.1365

Molecular Weight: 297.35

Elemental Analysis: C, 72.71; H, 6.44; N, 4.71; O, 16.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Glaziovine
IUPAC/Chemical Name
(±)-2',3',8',8a'-Tetrahydro-6'-hydroxy-5'-methoxy-1'-methylspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one
InChi Key
PNJUPRNTSWJWAX-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19NO3/c1-19-8-5-11-9-14(22-2)17(21)16-15(11)13(19)10-18(16)6-3-12(20)4-7-18/h3-4,6-7,9,13,21H,5,8,10H2,1-2H3
SMILES Code
O=C1C=CC2(C3=C4C(C2)N(C)CCC4=CC(OC)=C3O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 297.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: da Silva FM, de Souza AD, Koolen HH, Barison A, Vendramin ME, Costa EV, Ferreira AG, Pinheiro ML. Phytochemical study of the alkaloidal fractions of Unonopsis duckei R. E. Fr. guided by electrospray ionisation ion-trap tandem mass spectrometry. Phytochem Anal. 2014 Jan-Feb;25(1):45-9. doi: 10.1002/pca.2458. Epub 2013 Aug 6. PubMed PMID: 23922254. 2: Li HT, Li WJ, Wu HM, Chen CY. Alkaloids from Cinnamomum philippinense. Nat Prod Commun. 2012 Dec;7(12):1581-2. PubMed PMID: 23413556. 3: Cheng P, Ma YB, Yao SY, Zhang Q, Wang EJ, Yan MH, Zhang XM, Zhang FX, Chen JJ. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5316-20. Epub 2007 Aug 16. PubMed PMID: 17723297. 4: Chang FR, Wei JL, Teng CM, Wu YC. Antiplatelet aggregation constituents from Annona purpurea. J Nat Prod. 1998 Dec;61(12):1457-61. PubMed PMID: 9868142. 5: Sun SW, Lee SS, Huang HM. Determination of lauraceous aporphine alkaloids by high-performance liquid chromatography. J Pharm Biomed Anal. 1996 Jun;14(8-10):1383-7. PubMed PMID: 8818061. 6: Marzo A, Ghirardi P, Casagrande C, Catenazzo G, Mantero O. Preliminiary data on the pharmacokinetics of glaziovine in man. Eur J Clin Pharmacol. 1978 May 31;13(3):219-22. PubMed PMID: 668777. 7: Chaumontet M, Capt M, Gold-Aubert P. Comparative study of two anti-ulcerogenic drugs--glaziovine and sulpiride. Arzneimittelforschung. 1978;28(11):2119-21. PubMed PMID: 582915. 8: Vecchietti V, Casagrande C, Ferrari G. Alkaloids of Ocotea brachybotra. Farmaco Sci. 1977 Nov;32(11):767-9. PubMed PMID: 923790. 9: Sardini D, Marzo A. [Quantitative determination of glaziovine]. Farmaco Prat. 1977 Oct;32(10):503-11. Italian. PubMed PMID: 923761. 10: Marzo A, Ghirardi P, Merlo L, Marchetti G. Absorption, fate and excretion of glaziovine-14C in the dog. Arch Int Pharmacodyn Ther. 1977 Jun;227(2):254-62. PubMed PMID: 907410. 11: Melloni G, Camerini L. [Clinical study on the use of glaziovine in the internal medicine]. Clin Ter. 1975 Nov 30;75(4):343-54. Italian. PubMed PMID: 776511. 12: Marzo A, Ghirardi P, Parenti MA, Merlo L, Marchetti G. [Plasma levels and urinary elimination of glaziovine after oral and intravenous administration in conscious dogs]. Boll Soc Ital Biol Sper. 1975 Jun 15;51(11):681-3. Italian. PubMed PMID: 1222084. 13: Ferrini R, Miragoli G. [Effect of glaziovine on exploratory activity of aggressive mice in the so-called "holey board" test]. Boll Soc Ital Biol Sper. 1974 Oct 15;50(19):1635-8. Italian. PubMed PMID: 4156479. 14: Ferrini R, Miragoli G. [The effect of glaziovine on exploratory behavior of normal mice in the so-called "holey board" test]. Boll Soc Ital Biol Sper. 1974 Oct 15;50(19):1629-34. Italian. PubMed PMID: 4156478. 15: Buffa B, Costa G, Ghirardi P. Glaziovine versus diazepam: a double-blind clinical trial. Curr Ther Res Clin Exp. 1974 Jun;16(6):621-7. PubMed PMID: 4211143. 16: Kametani T, Yagi H. Total syntheses of (plus or minus)-glaziovine and (plus or minus)-pronuciferine by phenolic oxidative coupling. J Chem Soc Perkin 1. 1967;21:2182-4. PubMed PMID: 6069796.