MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 584380 | Name: E 4441

Description:

WARNING: This product is for research use only, not for human or veterinary use.

E 4441 is a third-generation difluoroquinolone and shows satisfactory levels of activity, both in vitro and in vivo, its activity against G(+) aerobic bacteria and anaerobic bacteria.

Chemical Structure

E 4441
E 4441
CAS#124668-12-8

Theoretical Analysis

MedKoo Cat#: 584380

Name: E 4441

CAS#: 124668-12-8

Chemical Formula: C17H17F2N3O3

Exact Mass: 349.1238

Molecular Weight: 349.34

Elemental Analysis: C, 58.45; H, 4.91; F, 10.88; N, 12.03; O, 13.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
E 4441; E-4441; E4441
IUPAC/Chemical Name
3-Quinolinecarboxylic acid, 7-(3-amino-3-methyl-1-azetidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-
InChi Key
FEMZVDSBIXDODB-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17F2N3O3/c1-17(20)6-21(7-17)14-11(18)4-9-13(12(14)19)22(8-2-3-8)5-10(15(9)23)16(24)25/h4-5,8H,2-3,6-7,20H2,1H3,(H,24,25)
SMILES Code
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CC(C)(N)C4)=C3F)C1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 349.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Martinez L, Basi N, Dordal A, Roser R, Sagarra R. A pharmacokinetic study of E-4441, a new quinolone, in the rat, mouse and cynomolgus monkey. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:352-6. PubMed PMID: 1668199. 2: Esteve M, Moros M, Coll R, Xicota MA, Llovera S. Antimicrobial activity of E-4441, a representative azetidine quinolone. Drugs Exp Clin Res. 1990;16(9):445-9. PubMed PMID: 2100245. 3: Gargallo-Viola D, Esteve M, Moros M, Coll R, Xicota MA, de Andres C, Roser R, Guinea J. Comparative in vitro and in vivo activities of six new monofluoroquinolone and difluoroquinolone 3-carboxylic acids with a 7-azetidin ring substituent. Antimicrob Agents Chemother. 1990 Dec;34(12):2318-26. PubMed PMID: 2088187; PubMed Central PMCID: PMC172054.