MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 562323 | Name: CAY10444
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CAY10444 is a S1P3 (shingosine-1-phosphate receptor) specific antagonist.

Chemical Structure

CAY10444
CAY10444
CAS#298186-80-8

Theoretical Analysis

MedKoo Cat#: 562323

Name: CAY10444

CAS#: 298186-80-8

Chemical Formula: C15H29NO2S

Exact Mass: 287.1919

Molecular Weight: 287.46

Elemental Analysis: C, 62.67; H, 10.17; N, 4.87; O, 11.13; S, 11.15

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 3,950.00 2 Weeks
2g USD 6,450.00 2 Weeks
Show More
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
CAY10444; CAY-10444; CAY 10444; BML-241; BML 241; BML241;
IUPAC/Chemical Name
(4R)-2-Undecyl-4-thiazolidinecarboxylic acid
InChi Key
FNBSOIBCKUUVJJ-LSLKUGRBSA-N
InChi Code
InChI=1S/C15H29NO2S/c1-2-3-4-5-6-7-8-9-10-11-14-16-13(12-19-14)15(17)18/h13-14,16H,2-12H2,1H3,(H,17,18)/t13-,14?/m0/s1
SMILES Code
O=C([C@H]1NC(CCCCCCCCCCC)SC1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 287.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tang HB, Jiang XJ, Wang C, Liu SC. S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. Biochem Biophys Res Commun. 2018 Mar 16. pii: S0006-291X(18)30543-6. doi: 10.1016/j.bbrc.2018.03.065. [Epub ahead of print] PubMed PMID: 29534963. 2: Shirakawa H, Katsumoto R, Iida S, Miyake T, Higuchi T, Nagashima T, Nagayasu K, Nakagawa T, Kaneko S. Sphingosine-1-phosphate induces Ca(2+) signaling and CXCL1 release via TRPC6 channel in astrocytes. Glia. 2017 Jun;65(6):1005-1016. doi: 10.1002/glia.23141. Epub 2017 Mar 16. PubMed PMID: 28300348. 3: Feuerborn R, Becker S, Potì F, Nagel P, Brodde M, Schmidt H, Christoffersen C, Ceglarek U, Burkhardt R, Nofer JR. High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. Atherosclerosis. 2017 Feb;257:29-37. doi: 10.1016/j.atherosclerosis.2016.12.009. Epub 2016 Dec 9. PubMed PMID: 28038379. 4: Tian T, Tian W, Yang F, Zhao R, Huang Q, Zhao Y. Sphingosine kinase 1 inhibition improves lipopolysaccharide/D-galactosamine-induced acute liver failure by inhibiting mitogen-activated protein kinases pathway. United European Gastroenterol J. 2016 Oct;4(5):677-685. Epub 2016 Mar 2. PubMed PMID: 27733910; PubMed Central PMCID: PMC5042311. 5: Tölle M, Klöckl L, Wiedon A, Zidek W, van der Giet M, Schuchardt M. Regulation of endothelial nitric oxide synthase activation in endothelial cells by S1P1 and S1P3. Biochem Biophys Res Commun. 2016 Aug 5;476(4):627-634. doi: 10.1016/j.bbrc.2016.06.009. Epub 2016 Jun 7. PubMed PMID: 27282481. 6: Zhao C, Moreno-Nieves U, Di Battista JA, Fernandes MJ, Touaibia M, Bourgoin SG. Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts. Mediators Inflamm. 2015;2015:436525. doi: 10.1155/2015/436525. Epub 2015 Oct 18. PubMed PMID: 26556954; PubMed Central PMCID: PMC4628658. 7: Wang H, Cai KY, Li W, Huang H. Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate Receptor 3/Platelet-Derived Growth Factor Receptor-β. Cell Mol Biol Lett. 2015 Dec;20(4):597-611. doi: 10.1515/cmble-2015-0035. PubMed PMID: 26208383. 8: Li C, Li JN, Kays J, Guerrero M, Nicol GD. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation. 2015 Apr 12;12:70. doi: 10.1186/s12974-015-0286-8. PubMed PMID: 25880547; PubMed Central PMCID: PMC4397880. 9: Zhu C, Cao C, Dai L, Yuan J, Li S. Corticotrophin-releasing factor participates in S1PR3-dependent cPLA2 expression and cell motility in vascular smooth muscle cells. Vascul Pharmacol. 2015 Aug;71:116-26. doi: 10.1016/j.vph.2015.03.013. Epub 2015 Apr 10. PubMed PMID: 25869501. 10: Lin CC, Lee IT, Hsu CH, Hsu CK, Chi PL, Hsiao LD, Yang CM. Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation. PLoS One. 2015 Mar 3;10(3):e0118473. doi: 10.1371/journal.pone.0118473. eCollection 2015. PubMed PMID: 25734900; PubMed Central PMCID: PMC4348486. 11: Zhang DD, Linke B, Suo J, Zivkovic A, Schreiber Y, Ferreirós N, Henke M, Geisslinger G, Stark H, Scholich K. Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. Biol Chem. 2015 Jun;396(6-7):783-94. doi: 10.1515/hsz-2014-0276. PubMed PMID: 25720064. 12: Hsu CK, Lee IT, Lin CC, Hsiao LD, Yang CM. Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. J Cell Physiol. 2015 Mar;230(3):702-15. doi: 10.1002/jcp.24795. PubMed PMID: 25201048. 13: Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1788-94. doi: 10.1161/ATVBAHA.113.301300. Epub 2013 May 30. PubMed PMID: 23723371; PubMed Central PMCID: PMC3794714. 14: Nakahara T, Iwase A, Nakamura T, Kondo M, Bayasula, Kobayashi H, Takikawa S, Manabe S, Goto M, Kotani T, Kikkawa F. Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. Fertil Steril. 2012 Oct;98(4):1001-8.e1. doi: 10.1016/j.fertnstert.2012.06.008. Epub 2012 Jul 3. PubMed PMID: 22763095. 15: Lim M, Choi SK, Cho YE, Yeon SI, Kim EC, Ahn DS, Lee YH. The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. PLoS One. 2012;7(4):e35177. doi: 10.1371/journal.pone.0035177. Epub 2012 Apr 20. PubMed PMID: 22532844; PubMed Central PMCID: PMC3332110. 16: Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T. Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. J Cell Biochem. 2011 Nov;112(11):3449-58. doi: 10.1002/jcb.23275. PubMed PMID: 21769916. 17: Pyne NJ, Pyne S. Selectivity and specificity of sphingosine 1-phosphate receptor ligands: "off-targets" or complex pharmacology? Front Pharmacol. 2011 May 31;2:26. doi: 10.3389/fphar.2011.00026. eCollection 2011. PubMed PMID: 21687518; PubMed Central PMCID: PMC3108476. 18: Salomone S, Waeber C. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9. doi: 10.3389/fphar.2011.00009. eCollection 2011. PubMed PMID: 21687504; PubMed Central PMCID: PMC3110020. 19: Tao R, Hoover HE, Honbo N, Kalinowski M, Alano CC, Karliner JS, Raffai R. High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1022-8. doi: 10.1152/ajpheart.00902.2009. Epub 2010 Jan 8. PubMed PMID: 20061542; PubMed Central PMCID: PMC2838562. 20: Tao R, Hoover HE, Zhang J, Honbo N, Alano CC, Karliner JS. Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization. J Cardiovasc Pharmacol. 2009 Jun;53(6):486-94. doi: 10.1097/FJC.0b013e3181a7b58a. PubMed PMID: 19433984; PubMed Central PMCID: PMC2835551.