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MedKoo Cat#: 330118 | Name: Chlorotoluron
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorotoluron is a pheylurea herbicide that has been used to control growth of broad-leaved weeds in winter wheat, rye, barley, and triticale crops.

Chemical Structure

Chlorotoluron
Chlorotoluron
CAS# 15545-48-9

Theoretical Analysis

MedKoo Cat#: 330118

Name: Chlorotoluron

CAS#: 15545-48-9

Chemical Formula: C10H13ClN2O

Exact Mass: 212.0716

Molecular Weight: 212.68

Elemental Analysis: C, 56.48; H, 6.16; Cl, 16.67; N, 13.17; O, 7.52

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
Chlorotoluron; Dicuran; Dikurin;
IUPAC/Chemical Name
N'-(3-Chloro-4-methylphenyl)-N,N-dimethylurea
InChi Key
JXCGFZXSOMJFOA-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H13ClN2O/c1-7-4-5-8(6-9(7)11)12-10(14)13(2)3/h4-6H,1-3H3,(H,12,14)
SMILES Code
O=C(NC1=CC=C(C)C(Cl)=C1)N(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 212.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bányiová K, Čupr P, Kohoutek J. An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron. Environ Sci Pollut Res Int. 2015 Jul;22(14):10713-20. doi: 10.1007/s11356-015-4252-x. Epub 2015 Mar 11. PubMed PMID: 25752630. 2: Gion K, Inui H, Takakuma K, Yamada T, Kambara Y, Nakai S, Fujiwara H, Miyamura T, Imaishi H, Ohkawa H. Molecular mechanisms of herbicide-inducible gene expression of tobacco CYP71AH11 metabolizing the herbicide chlorotoluron. Pestic Biochem Physiol. 2014 Jan;108:49-57. doi: 10.1016/j.pestbp.2013.12.003. Epub 2014 Jan 3. PubMed PMID: 24485315. 3: Oliver RG, Wallace DF, Earll M. Variation in chlorotoluron photodegradation rates as a result of seasonal changes in the composition of natural waters. Pest Manag Sci. 2013 Jan;69(1):120-5. doi: 10.1002/ps.3377. Epub 2012 Aug 27. PubMed PMID: 22927226. 4: Nélieu S, Bonnemoy F, Bonnet JL, Lefeuvre L, Baudiffier D, Heydorff M, Quéméneur A, Azam D, Ducrot PH, Lagadic L, Bohatier J, Einhorn J. Ecotoxicological effects of diuron and chlorotoluron nitrate-induced photodegradation products: monospecific and aquatic mesocosm-integrated studies. Environ Toxicol Chem. 2010 Dec;29(12):2644-52. doi: 10.1002/etc.341. Epub 2010 Oct 7. PubMed PMID: 20931608. 5: Zhou Q, Zhang X, Xie G, Xiao J. Temperature-controlled ionic liquid-dispersive liquid-phase microextraction for preconcentration of chlorotoluron, diethofencarb and chlorbenzuron in water samples. J Sep Sci. 2009 Nov;32(22):3945-50. doi: 10.1002/jssc.200900444. PubMed PMID: 19877152. 6: Song NH, Zhang S, Hong M, Yang H. Impact of dissolved organic matter on bioavailability of chlorotoluron to wheat. Environ Pollut. 2010 Mar;158(3):906-12. doi: 10.1016/j.envpol.2009.09.019. Epub 2009 Oct 12. PubMed PMID: 19819600. 7: Nélieu S, Perreau F, Bonnemoy F, Ollitrault M, Azam D, Lagadic L, Bohatier J, Einhorn J. Sunlight nitrate-induced photodegradation of chlorotoluron: evidence of the process in aquatic mesocosms. Environ Sci Technol. 2009 May 1;43(9):3148-54. PubMed PMID: 19534127. 8: Badawi N, Rønhede S, Olsson S, Kragelund BB, Johnsen AH, Jacobsen OS, Aamand J. Metabolites of the phenylurea herbicides chlorotoluron, diuron, isoproturon and linuron produced by the soil fungus Mortierella sp. Environ Pollut. 2009 Oct;157(10):2806-12. doi: 10.1016/j.envpol.2009.04.019. Epub 2009 May 22. PubMed PMID: 19464778. 9: Hiller E, Krascsenits Z, Cernanský S. Sorption of acetochlor, atrazine, 2,4-D, chlorotoluron, MCPA, and trifluralin in six soils from Slovakia. Bull Environ Contam Toxicol. 2008 May;80(5):412-6. doi: 10.1007/s00128-008-9430-9. Epub 2008 Apr 10. PubMed PMID: 18401535. 10: Mu H, Zhang P, Xu J. Testicular toxicity and mechanisms of chlorotoluron compounds in the mouse. Toxicol Mech Methods. 2008;18(5):399-403. doi: 10.1080/15376510701533921. PubMed PMID: 20020863. 11: Gao ML, Dai SG, Ma YM, Zhang P. Impact of atrazine and nitrogen fertilizers on the sorption of chlorotoluron in soil and model sorbents. J Environ Sci (China). 2007;19(3):327-31. PubMed PMID: 17918595. 12: Song NH, Yin XL, Chen GF, Yang H. Biological responses of wheat (Triticum aestivum) plants to the herbicide chlorotoluron in soils. Chemosphere. 2007 Aug;68(9):1779-87. Epub 2007 Apr 25. PubMed PMID: 17462703. 13: Hong M, Ping Z, Jian X. Testicular toxicity and mechanisms of chlorotoluron compounds in the mouse. Toxicol Mech Methods. 2007;17(8):483-8. doi: 10.1080/15376510601166384. PubMed PMID: 20020875. 14: Haque MM, Muneer M, Bahnemann DW. Semiconductor-mediated Photocatalyzed degradation of a herbicide derivative, chlorotoluron, in aqueous suspensions. Environ Sci Technol. 2006 Aug 1;40(15):4765-70. PubMed PMID: 16913136. 15: Song NH, Yang ZM, Zhou LX, Wu X, Yang H. Effect of dissolved organic matter on the toxicity of chlorotoluron to Triticum aestivum. J Environ Sci (China). 2006;18(1):101-8. PubMed PMID: 20050556. 16: Rouchaud J, Neus O, Bulcke R, Cools K, Eelen H, Dekkers T. Soil dissipation of diuron, chlorotoluron, simazine, propyzamide, and diflufenican herbicides after repeated applications in fruit tree orchards. Arch Environ Contam Toxicol. 2000 Jul;39(1):60-5. PubMed PMID: 10790503. 17: Krugman T, Korol A, Nevo E, Snape JW, Levy O, Rubin B. Comparative RFLP mapping of the chlorotoluron resistance gene (Su1) in cultivated wheat (Triticum aestivum) and wild wheat (Triticum dicoccoides). Theor Appl Genet. 1997 Jan;94(1):46-51. doi: 10.1007/s001220050380. PubMed PMID: 19352744. 18: Schoket B, Vincze I. Dose-related induction of rat hepatic drug-metabolizing enzymes by diuron and chlorotoluron, two substituted phenylurea herbicides. Toxicol Lett. 1990 Jan;50(1):1-7. PubMed PMID: 2104995. 19: Lin TH, Menzer RE, North HH. Metabolism in human embryonic lung cell cultures of three phenylurea herbicides: chlorotoluron, fluometuron, and metobromuron. J Agric Food Chem. 1976 Jul-Aug;24(4):759-63. PubMed PMID: 956539.

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