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MedKoo Cat#: 584377 | Name: Alminoprofen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alminoprofen is a nonsteroidal anti-inflammatory agent that was found to significantly suppress passive anaphylactic bronchoconstrictions at 30 mg/kg given intraduodenally, while ibuprofen did not at the same doses.

Chemical Structure

Alminoprofen
Alminoprofen
CAS#39718-89-3

Theoretical Analysis

MedKoo Cat#: 584377

Name: Alminoprofen

CAS#: 39718-89-3

Chemical Formula: C13H17NO2

Exact Mass: 219.1259

Molecular Weight: 219.28

Elemental Analysis: C, 71.21; H, 7.81; N, 6.39; O, 14.59

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Related CAS #
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Synonym
Alminoprofen; EB 382; EB-382; EB382
IUPAC/Chemical Name
Benzeneacetic acid, alpha-methyl-4-((2-methyl-2-propenyl)amino)-
InChi Key
FPHLBGOJWPEVME-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H17NO2/c1-9(2)8-14-12-6-4-11(5-7-12)10(3)13(15)16/h4-7,10,14H,1,8H2,2-3H3,(H,15,16)
SMILES Code
O=C(O)C(C)C1=CC=C(NCC(C)=C)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 219.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hanada S, Fujioka K, Futamura Y, Manabe N, Hoshino A, Yamamoto K. Evaluation of anti-inflammatory drug-conjugated silicon quantum dots: their cytotoxicity and biological effect. Int J Mol Sci. 2013 Jan 10;14(1):1323-34. doi: 10.3390/ijms14011323. PubMed PMID: 23306154; PubMed Central PMCID: PMC3565323. 2: Syed NI, Zehra F, Syed AA, Karim S, Khan FZ. Comparing the effects of salts of diclofenac and alminoprofen with aspirin on serum electrolytes, creatinine and urea levels in rabbits. Pak J Pharm Sci. 2012 Oct;25(4):777-82. PubMed PMID: 23009994. 3: Maeda E, Uematsu T. [The anti-pyretic mechanism of alminoprofen]. Nihon Yakurigaku Zasshi. 1991 Dec;98(6):457-66. Japanese. PubMed PMID: 1783327. 4: Paillet M, Merdjan H, Brouard A, Doucet D, Barreteau H, Fredj G. Rapid determination of alminoprofen in plasma by high-performance liquid chromatography. J Chromatogr. 1985 Oct 11;343(2):455-9. PubMed PMID: 4066887. 5: Maeda E, Hujiyoshi T, Uematsu T. [Effects of alminoprofen on sodium urate crystal-induced inflammation]. Nihon Yakurigaku Zasshi. 1991 Dec;98(6):467-74. Japanese. PubMed PMID: 1783328. 6: Paillet M, Merdjan H, Doucet D. [Pharmacokinetics of alminoprofen in healthy subjects. Influence of the time of administration]. Therapie. 1986 Nov-Dec;41(6):413-6. French. PubMed PMID: 3810535. 7: Tod M, Pobel C, Le Gros V, Louchahi K, Petitjean O, Brion N, Garcia-Mace JL. A population pharmacokinetic study of alminoprofen penetration into synovial fluid. Biopharm Drug Dispos. 1995 Nov;16(8):627-34. PubMed PMID: 8573683. 8: Nishioka K, Tanaka T, Mobunaga M. [Result of a double-blind clinical study of EB-382 (Alminoprofen) in rheumatoid arthritis]. Ryumachi. 1986 Jun;26(3):210-20. Japanese. PubMed PMID: 3538445. 9: Fujiyoshi T, Kuwashima M, Iida H, Uematsu T. A new writhing model of factor XII activator-induced pain for assessment of non-steroidal anti-inflammatory agents. I. Kaolin-induced writhing in mice. J Pharmacobiodyn. 1989 Mar;12(3):132-6. PubMed PMID: 2668495. 10: Kojima E, Tamura N, Higashide Y, Lee B, Yamaura T, Ohnishi H. [Effects of alminoprofen on the allergic reactions]. Nihon Yakurigaku Zasshi. 1990 Dec;96(6):315-21. Japanese. PubMed PMID: 2076851. 11: Raguenes-Nicol C, Russo-Marie F, Domage G, Diab N, Solito E, Dray F, Mace JL, Streichenberger G. Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway. Biochem Pharmacol. 1999 Feb 15;57(4):433-43. PubMed PMID: 9933032. 12: Shin K, Takasaki M, Katsunuma H, Sato K, Shibuya T, Sato S, Hirayama H. [Pharmacokinetics of oral alminoprofen (Minalfen) in elderly patients with rheumatoid arthritis and spondylosis deformans]. Nihon Ronen Igakkai Zasshi. 1992 Nov;29(11):881-7. Japanese. PubMed PMID: 1491485. 13: Le Coz CJ, Bottlaender A, Scrivener JN, Santinelli F, Cribier BJ, Heid E, Grosshans EM. Photocontact dermatitis from ketoprofen and tiaprofenic acid: cross-reactivity study in 12 consecutive patients. Contact Dermatitis. 1998 May;38(5):245-52. PubMed PMID: 9667440. 14: Fujiyoshi T, Iida H, Kuwashima M, Dozen M, Taniguchi N, Ikeda K. Pharmacological profile of alminoprofen among four writhing models of mice caused by kaolin, zymosan, acetylcholine and phenylquinone. J Pharmacobiodyn. 1990 Jan;13(1):44-8. PubMed PMID: 2341969. 15: Premel-Cabic A, Allain P, Pidhorz L, Streichenberger G. Pharmacokinetics of 2-(p-methylallylaminophenyl) propionic acid, alminoprofene, in man after single and multiple oral doses. Eur J Clin Pharmacol. 1980 Nov;18(5):419-22. PubMed PMID: 7439265. 16: Fujiyoshi T, Iida H, Murakami M, Kuwashima M, Uematsu T. Pharmacological studies on EB-382, a new non-steroidal antiinflammatory agents: mode of action of the analgesic effects. Chem Pharm Bull (Tokyo). 1989 Mar;37(3):775-7. PubMed PMID: 2787705. 17: Fujiyoshi T, Iida H, Murakami M, Kuwashima M, Uematsu T. Pharmacological studies on EB-382, a new non-steroidal antiinflammatory agent: mode of action of the antiinflammatory effects. Chem Pharm Bull (Tokyo). 1989 Mar;37(3):771-4. PubMed PMID: 2752492. 18: Premel-Cabic A, Chaleil D, Bonniot R, Riberi P, Streichenberger G, Allain P. [Comparative study of alminoprofene elimination in healthy subjects and in patients with renal or hepatic insufficiency (author's transl)]. Therapie. 1981 Jan-Feb;36(1):41-6. French. PubMed PMID: 7233371. 19: Nemoto T, Lee XP, Kumazawa T, Hasegawa C, Fujishiro M, Marumo A, Shouji Y, Inagaki K, Sato K. High-throughput determination of nonsteroidal anti-inflammatory drugs in human plasma by HILIC-MS/MS. J Pharm Biomed Anal. 2014 Jan;88:71-80. doi: 10.1016/j.jpba.2013.08.023. Epub 2013 Aug 29. PubMed PMID: 24036363. 20: Fujiyoshi T, Ikeda K, Saito M, Yamaura T, Iida H, Maeda E, Kase N, Uematsu T. [The antiinflammatory effect of EB-382]. Nihon Yakurigaku Zasshi. 1986 Apr;87(4):379-95. Japanese. PubMed PMID: 3087847.