Synonym
YM 534; YM-534; YM534.
IUPAC/Chemical Name
Hexanoic acid, 6-(4-((5-(1H-imidazol-1-yl)pentyl)oxy)phenoxy)-2,2-dimethyl-, ethyl ester
InChi Key
OFCXZLBZYMCRLB-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H36N2O4/c1-4-28-23(27)24(2,3)14-6-9-19-30-22-12-10-21(11-13-22)29-18-8-5-7-16-26-17-15-25-20-26/h10-13,15,17,20H,4-9,14,16,18-19H2,1-3H3
SMILES Code
C(C(CCCCOc1ccc(cc1)OCCCCCn1ccnc1)(C)C)(=O)OCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
416.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kanamaru R, Ishioka C, Konishi Y, Ishikawa S, Shibata H, Wakui A. [DNA damage and anticancer effect]. Gan To Kagaku Ryoho. 1990 Mar;17(3 Pt 2):517-23. Review. Japanese. PubMed PMID: 2181939.
2: Kanamaru R, Ishioka C, Konishi Y, Ishikawa A, Shibata H, Wakui A. Damage to DNA strand and the effects of anticancer drugs. Sci Rep Res Inst Tohoku Univ Med. 1989 Dec;36(1-4):29-36. PubMed PMID: 2640065.
3: Kanamaru R, Ishioka C, Konishi Y, Ishikawa A, Shibata H, Wakui A. Mechanism of action of the synthetic imidazole compound YM 534 on human promyelocytic leukemia line HL-60 cells. Anticancer Drug Des. 1989 Aug;4(2):137-44. PubMed PMID: 2803462.
4: Sato S, Watanabe Y, Okamura K, Hamanaka R, Mori T, Kohno K, Kuwano M. Potentiation of vincristine and actinomycin D by a new synthetic imidazole anti-tumor agent YM534 active against human cancer cells and multidrug-resistant cells. Anticancer Drug Des. 1989 Aug;4(2):125-35. PubMed PMID: 2803461.
