JH-VIII-49 | CDK8 inhibitor

MedKoo Cat#: 407893 | Name: JH-VIII-49

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JH-VIII-49 is a potent and selective CDK8 inhibitor.

Chemical Structure

JH-VIII-49

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 407893

Name: JH-VIII-49

CAS#: Unknown

Chemical Formula: C30H40N2

Exact Mass: 428.3191

Molecular Weight: 428.66

Elemental Analysis: C, 84.06; H, 9.41; N, 6.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JH-VIII-49; JH-VIII49; JH-VIII 49; JHVIII-49; JHVIII49; JHVIII 49;

IUPAC/Chemical Name

(3S,8S,10R,13S,14S,17S)-17-(isoquinolin-7-yl)-N,N,10,13-tetramethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-amine

InChi Key

IWZSHWBGHQBIML-ZGGLMWTQSA-N

InChi Code

InChI=1S/C30H40N2/c1-29-14-11-24(32(3)4)18-23(29)7-8-25-27-10-9-26(30(27,2)15-12-28(25)29)21-6-5-20-13-16-31-19-22(20)17-21/h5-7,13,16-17,19,24-28H,8-12,14-15,18H2,1-4H3/t24-,25-,26+,27-,28?,29-,30+/m0/s1

SMILES Code

C[C@@]12[C@@H](C3=CC4=C(C=C3)C=CN=C4)CC[C@@]1([H])[C@]5([H])CC=C6C[C@@H](N(C)C)CC[C@]6(C)C5CC2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 428.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 John M. Hatcher, Eric S. Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim and Nathanael S. Gray Publication Date (Web): March 18, 2018 (Letter) DOI: 10.1021/acsmedchemlett.8b00011