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MedKoo Cat#: 571516 | Name: Achillin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Achillin is a compound isolated from herbs that may have anti-inflammatory and anti-carcinogenic activities.

Chemical Structure

Achillin
Achillin
CAS#5956-04-7

Theoretical Analysis

MedKoo Cat#: 571516

Name: Achillin

CAS#: 5956-04-7

Chemical Formula: C15H18O3

Exact Mass: 246.1256

Molecular Weight: 246.31

Elemental Analysis: C, 73.15; H, 7.37; O, 19.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Achillin; NSC156236; NSC-156236; NSC 156236
IUPAC/Chemical Name
3,6,9-trimethyl-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione
InChi Key
BJPSSVHNEGMBDQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H18O3/c1-7-4-5-10-9(3)15(17)18-14(10)13-8(2)6-11(16)12(7)13/h6,9-10,13-14H,4-5H2,1-3H3
SMILES Code
CC1C2CCC(C)=C3C(C(C)=CC3=O)C2OC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Glasl S, Mucaji P, Werner I, Jurenitsch J. TLC and HPLC characteristics of desacetylmatricarin, leucodin, achillin and their 8alpha-angeloxy-derivatives. Pharmazie. 2003 Jul;58(7):487-90. PubMed PMID: 12889533. 2: Mullally JE, Fitzpatrick FA. Pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death. Mol Pharmacol. 2002 Aug;62(2):351-8. PubMed PMID: 12130688. 3: Zitterl-Eglseer K, Jurenitsch J, Korhammer S, Haslinger E, Sosa S, Della Loggia R, Kubelka W, Franz C. [Sesquiterpenelactones of Achillea setacea with antiphlogistic activity]. Planta Med. 1991 Oct;57(5):444-6. German. PubMed PMID: 1798798. 4: Schepetkin IA, Kirpotina LN, Mitchell PT, Kishkentaeva АS, Shaimerdenova ZR, Atazhanova GA, Adekenov SM, Quinn MT. The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation. Phytochemistry. 2018 Feb;146:36-46. doi: 10.1016/j.phytochem.2017.11.010. Epub 2017 Dec 22. PubMed PMID: 29216473; PubMed Central PMCID: PMC5750123. 5: Tschiggerl C, Bucar F. Guaianolides and volatile compounds in chamomile tea. Plant Foods Hum Nutr. 2012 Jun;67(2):129-35. doi: 10.1007/s11130-012-0277-1. PubMed PMID: 22410959. 6: Zaghloul AM, Yusufoglu HS, Salkini MA, Alam A. New cytotoxic sesquiterpene lactones from Anthemis scrobicularis. J Asian Nat Prod Res. 2014;16(9):922-9. doi: 10.1080/10286020.2014.931377. Epub 2014 Sep 17. PubMed PMID: 25227949. 7: Kim YS, Bahn KN, Hah CK, Gang HI, Ha YL. Inhibition of 7,12-dimethylbenz[a]anthracene induced mouse skin carcinogenesis by Artemisia capillaris. J Food Sci. 2008 Jan;73(1):T16-20. doi: 10.1111/j.1750-3841.2007.00585.x. PubMed PMID: 18211378. 8: Glasl S, Mucaji P, Werner I, Presser A, Jurenitsch J. Sesquiterpenes and flavonoid aglycones from a Hungarian taxon of the Achillea millefolium group. Z Naturforsch C. 2002 Nov-Dec;57(11-12):976-82. PubMed PMID: 12562079. 9: Cheong H, Choi EJ, Yoo GS, Kim KM, Ryu SY. Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum. Planta Med. 1998 Aug;64(6):577-8. Erratum in: Planta Med 1998 Dec;64(8):769. Ho C [corrected to Cheong H]. PubMed PMID: 9741305. 10: Kang TH, Pae HO, Jeong SJ, Yoo JC, Choi BM, Jun CD, Chung HT, Miyamoto T, Higuchi R, Kim YC. Scopoletin: an inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei. Planta Med. 1999 Jun;65(5):400-3. PubMed PMID: 10418323. 11: Zapata-Martínez J, Sánchez-Toranzo G, Chaín F, Catalán CA, Bühler MI. Effect of guaianolides in the meiosis reinitiation of amphibian oocytes. Zygote. 2017 Feb;25(1):10-16. doi: 10.1017/S0967199416000265. Epub 2016 Nov 3. PubMed PMID: 27806737.

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