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MedKoo Cat#: 581135 | Name: Berlopentin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Berlopentin is splenopentin analog used to treat HIV positive patients; has immunostimulatory properties. Splenopentin--influence on antibody formation in immunosuppressed animals and on phagocytic capability of human granulocytes.

Chemical Structure

Berlopentin
CAS#91418-71-2

Theoretical Analysis

MedKoo Cat#: 581135

Name: Berlopentin

CAS#: 91418-71-2

Chemical Formula: C35H55N9O11

Exact Mass: 777.4021

Molecular Weight: 777.88

Elemental Analysis: C, 54.04; H, 7.13; N, 16.21; O, 22.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Berlopentin; DA SP-5; UNII-83GZC98HDD;
IUPAC/Chemical Name
(N(alpha)-Acetylarginyl)-(N(epsilon)-acetyllysyl)-glutamyl-valyl-tyrosine
InChi Key
KSWRINCJIKCVPA-RRUDZPKISA-N
InChi Code
InChI=1S/C35H55N9O11/c1-19(2)29(33(53)43-27(34(54)55)18-22-10-12-23(47)13-11-22)44-32(52)26(14-15-28(48)49)42-31(51)25(8-5-6-16-38-20(3)45)41-30(50)24(40-21(4)46)9-7-17-39-35(36)37/h10-13,19,24-27,29,47H,5-9,14-18H2,1-4H3,(H,38,45)(H,40,46)(H,41,50)(H,42,51)(H,43,53)(H,44,52)(H,48,49)(H,54,55)(H4,36,37,39)/t24-,25-,26-,27-,29-/m0/s1
SMILES Code
OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(C)=O)NC([C@H](CCCNC(N)=N)NC(C)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 777.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Simon HU, Kraul H, Schäfer R, Kilian U, Hoffmann A. Lack of effect of diacetyl-splenopentin (Berlopentin) on the pharmacokinetics of caffeine. Pharmazie. 1992 Jan;47(1):49-50. PubMed PMID: 1608985. 2: Greiner J, Miehe M, Weber H, Stoimenov A, Sönnichsen N, Diezel W. [Therapeutic use of splenopentin (DA SP-5) in patients with psoriasis arthropathica]. Dermatol Monatsschr. 1990;176(2-3):157-62. German. PubMed PMID: 2365110. 3: Simon HU, Piesch C, Furkert J, Schubert H, Schlenvoigt G. [Determination of Berlopentin in human plasma using an enzyme immunoassay]. Pharmazie. 1991 Feb;46(2):139-40. German. PubMed PMID: 1852764. 4: Diezel W, Eckert R, Müller GM, Forner K, Sönnichsen N. Splenopentin--influence on antibody formation in immunosuppressed animals and on phagocytic capability of human granulocytes. Arch Geschwulstforsch. 1989;59(3):161-4. PubMed PMID: 2667491.