MedKoo Cat#: 562291 | Name: Heclin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Heclin is a HECT E3 ubiquitin ligase inhibitor, which also acts by inhibiting Nedd4, Smurf2 and WWP1.

Chemical Structure

Heclin
Heclin
CAS#890605-54-6

Theoretical Analysis

MedKoo Cat#: 562291

Name: Heclin

CAS#: 890605-54-6

Chemical Formula: C17H17NO3

Exact Mass: 283.1208

Molecular Weight: 283.32

Elemental Analysis: C, 72.07; H, 6.05; N, 4.94; O, 16.94

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
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Related CAS #
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Synonym
Heclin;
IUPAC/Chemical Name
N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
InChi Key
SPTWXRJNCFIDRQ-ZHACJKMWSA-N
InChi Code
InChI=1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+
SMILES Code
O=C(NC1=CC=C(C(C)=O)C=C1)/C=C/C2=CC=C(CC)O2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 283.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Farris TR, Zhu B, Wang JY, McBride JW. Ehrlichia chaffeensis TRP32 Nucleomodulin Function and Localization Is Regulated by NEDD4L-Mediated Ubiquitination. Front Cell Infect Microbiol. 2018 Jan 11;7:534. doi: 10.3389/fcimb.2017.00534. eCollection 2017. PubMed PMID: 29376035; PubMed Central PMCID: PMC5768648. 2: Su BC, Chen JY. Antimicrobial Peptide Epinecidin-1 Modulates MyD88 Protein Levels via the Proteasome Degradation Pathway. Mar Drugs. 2017 Nov 16;15(11). pii: E362. doi: 10.3390/md15110362. PubMed PMID: 29144391; PubMed Central PMCID: PMC5706051. 3: Mund T, Lewis MJ, Maslen S, Pelham HR. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41. doi: 10.1073/pnas.1412152111. Epub 2014 Nov 10. PubMed PMID: 25385595; PubMed Central PMCID: PMC4250122.