SAR127303 is a potent covalent MAGL inhibitor. SAR127303 behaves as a selective and competitive inhibitor of mouse and human MAGL, which potently elevates hippocampal levels of 2-AG in mice. In vivo, SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain.
MedKoo Cat#: 555191
Name: SAR127303
CAS#: 1352011-38-1
Chemical Formula: C16H17ClF6N2O4S
Exact Mass: 482.0502
Molecular Weight: 482.82
Elemental Analysis: C, 39.80; H, 3.55; Cl, 7.34; F, 23.61; N, 5.80; O, 13.25; S, 6.64
The following data is based on the product molecular weight 482.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
