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MedKoo Cat#: 584372 | Name: E 0747

Description:

WARNING: This product is for research use only, not for human or veterinary use.

E 0747 is an antiarrhythmic agent of class 1C type of the Vaughan Williams' classification. E-0747 suppresses arrhythmia by inhibiting Na channels of cardiac cells and is expected to become a clinically useful antiarrhythmic drug.

Chemical Structure

E 0747
E 0747
CAS#99599-78-7

Theoretical Analysis

MedKoo Cat#: 584372

Name: E 0747

CAS#: 99599-78-7

Chemical Formula: C21H28ClN3O4

Exact Mass: 421.1768

Molecular Weight: 421.92

Elemental Analysis: C, 59.78; H, 6.69; Cl, 8.40; N, 9.96; O, 15.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
E 0747; E0747; E-0747
IUPAC/Chemical Name
Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 2,3-dihydro-6-chloro-2,2-dimethyl-1'-(3-(4-hydroxy-1-piperidinyl)propyl)-
InChi Key
VDDQRGRMFUGJDD-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H28ClN3O4/c1-20(2)13-21(16-12-14(22)4-5-17(16)29-20)18(27)25(19(28)23-21)9-3-8-24-10-6-15(26)7-11-24/h4-5,12,15,26H,3,6-11,13H2,1-2H3,(H,23,28)
SMILES Code
O=C1NC2(C(N1CCCN3CCC(O)CC3)=O)CC(C)(C)OC4=CC=C(Cl)C=C24
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mitsuhashi H, Akiyama K, Hashimoto K, Sawa Y, Hatori Y. Antiarrhythmic effects of a new drug, E-0747, on canine ventricular arrhythmia models. Jpn J Pharmacol. 1987 Jun;44(2):155-62. PubMed PMID: 3656773. 2: Sawada K, Shoji T, Igarashi T, Hiraoka M. Voltage- and rate-dependent depression of Vmax of action potentials by a new antiarrhythmic agent, E-0747, in swine cardiac Purkinje fibers. J Cardiovasc Pharmacol. 1987 Jan;9(1):51-6. PubMed PMID: 2434794. 3: Hamamoto T, Kojima M, Matsuzaki M, Kusukawa R, Ban T. A model study of time- and voltage-dependent effects of class I antiarrhythmic drugs in guinea-pig papillary muscles as related to external potassium concentration. Arzneimittelforschung. 1994 Aug;44(8):929-37. PubMed PMID: 7945535.